Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth.
Kazuyoshi Shiga,Masayasu Hara,Takaya Nagasaki,Takafumi Sato,Hiroki Takahashi,Hiromitsu Takeyama +5 more
TLDR
It is shown that CAFs are an important IL-6 source and that anti-IL-6 receptor antibody suppressed angiogenesis and inhibited tumor-stroma interactions, and CAFs contribute to drug-resistance acquisition in cancer cells.Abstract:
Cancer tissues are composed of cancer cells and the surrounding stromal cells (e.g., fibroblasts, vascular endothelial cells, and immune cells), in addition to the extracellular matrix. Most studies investigating carcinogenesis and the progression, invasion, metastasis, and angiogenesis of cancer have focused on alterations in cancer cells, including genetic and epigenetic changes. Recently, interactions between cancer cells and the stroma have attracted considerable attention, and increasing evidence has accumulated on this. Several researchers have gradually clarified the origins, features, and roles of cancer-associated fibroblasts (CAFs), a major component of the cancer stroma. CAFs function in a similar manner to myofibroblasts during wound healing. We previously reported the relationship between CAFs and angiogenesis. Interleukin-6 (IL-6), a multifunctional cytokine, plays a central role in regulating inflammatory and immune responses, and important roles in the progression, including proliferation, migration, and angiogenesis, of several cancers. We showed that CAFs are an important IL-6 source and that anti-IL-6 receptor antibody suppressed angiogenesis and inhibited tumor-stroma interactions. Furthermore, CAFs contribute to drug-resistance acquisition in cancer cells. The interaction between cancer cells and the stroma could be a potential target for anti-cancer therapy.read more
Citations
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Journal ArticleDOI
Targeting the tumour stroma to improve cancer therapy
TL;DR: An overview of the advances in understanding the complex cancer cell–tumour stroma interactions is provided and how this knowledge can result in more effective therapeutic strategies, which might ultimately improve patient outcomes are discussed.
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Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment
TL;DR: This review article summarized the recent progress in various nanoformulations for cancer therapy, with a special emphasis on tumour microenvironment stimuli-responsive ones, which it believes offer a good chance for the practical translation of nanoparticle formulas into clinic.
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Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer
TL;DR: The key roles of the IL-6 cytokine family in regulating innate and adaptive immunity, as well as other physiological responses are considered, which highlight the potential of targeting IL- 6 family members to treat inflammatory diseases and cancer.
Book ChapterDOI
Tumor-Derived Exosomes and Their Role in Cancer Progression.
TL;DR: Tumor-derived exosomes may interfere with cancer immunotherapy, but they also could serve as adjuvants and antigenic components of antitumor vaccines and are of potential interest as noninvasive biomarkers of cancer.
Journal ArticleDOI
Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas
Reuben Moncada,Dalia Barkley,Florian Wagner,Marta Chiodin,Joseph C. Devlin,Maayan Baron,Cristina H. Hajdu,Diane M. Simeone,Itai Yanai +8 more
TL;DR: Applying multimodal intersection analysis to primary pancreatic tumors, it is found that subpopulations of ductal cells, macrophages, dendritic cells and cancer cells have spatially restricted enrichments, as well as distinct coenrichments with other cell types.
References
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Journal ArticleDOI
Cancer-associated fibroblasts induce matrix metalloproteinase-mediated cetuximab resistance in head and neck squamous cell carcinoma cells.
Ann-Charlotte Johansson,Anna Ansell,Fredrik Jerhammar,Maja Bradic Lindh,Reidar Grénman,Eva Munck-Wikland,Arne Östman,Karin Roberg +7 more
TL;DR: A novel CAF-dependent modulation of cetuximab sensitivity is identified and inhibiting MMPs may improve the effects of EGFR-targeted therapy.
Journal ArticleDOI
Differential secretome analysis of cancer‐associated fibroblasts and bone marrow‐derived precursors to identify microenvironmental regulators of colon cancer progression
Astrid De Boeck,An Hendrix,Dawn M. Maynard,Mieke Van Bockstal,Annick Daniëls,Patrick Pauwels,Christian Gespach,Marc Bracke,Olivier De Wever +8 more
TL;DR: Immunohistochemistry validated the expression of selected candidates such as tenascin C, fibronectin ED‐A domain and stromal‐derived factor‐1 in clinical colon cancer specimens to identify a series of candidate biomarkers for colon cancer that are associated with a CAF‐specific phenotype.
Journal ArticleDOI
Acquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: a new role for G protein-coupled estrogen receptor in mediating tamoxifen resistance through cancer-associated fibroblast-derived fibronectin and β1-integrin signaling pathway in tumor cells
Jie Yuan,Manran Liu,Li Yang,Gang Tu,Qing Zhu,Maoshan Chen,Hong Cheng,Haojun Luo,Weijie Fu,Zhenhua Li,Guanglun Yang +10 more
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Expression of activated platelet-derived growth factor receptor in stromal cells of human colon carcinomas is associated with metastatic potential.
Yasuhiko Kitadai,Takamitsu Sasaki,Toshio Kuwai,Toru Nakamura,Corazon D. Bucana,Stanley R. Hamilton,Isaiah J. Fidler +6 more
TL;DR: The expression of PDGF‐Rβ in stromal cells is influenced by the organ‐specific microenvironment and is associated with metastatic potential.