Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth.
Kazuyoshi Shiga,Masayasu Hara,Takaya Nagasaki,Takafumi Sato,Hiroki Takahashi,Hiromitsu Takeyama +5 more
TLDR
It is shown that CAFs are an important IL-6 source and that anti-IL-6 receptor antibody suppressed angiogenesis and inhibited tumor-stroma interactions, and CAFs contribute to drug-resistance acquisition in cancer cells.Abstract:
Cancer tissues are composed of cancer cells and the surrounding stromal cells (e.g., fibroblasts, vascular endothelial cells, and immune cells), in addition to the extracellular matrix. Most studies investigating carcinogenesis and the progression, invasion, metastasis, and angiogenesis of cancer have focused on alterations in cancer cells, including genetic and epigenetic changes. Recently, interactions between cancer cells and the stroma have attracted considerable attention, and increasing evidence has accumulated on this. Several researchers have gradually clarified the origins, features, and roles of cancer-associated fibroblasts (CAFs), a major component of the cancer stroma. CAFs function in a similar manner to myofibroblasts during wound healing. We previously reported the relationship between CAFs and angiogenesis. Interleukin-6 (IL-6), a multifunctional cytokine, plays a central role in regulating inflammatory and immune responses, and important roles in the progression, including proliferation, migration, and angiogenesis, of several cancers. We showed that CAFs are an important IL-6 source and that anti-IL-6 receptor antibody suppressed angiogenesis and inhibited tumor-stroma interactions. Furthermore, CAFs contribute to drug-resistance acquisition in cancer cells. The interaction between cancer cells and the stroma could be a potential target for anti-cancer therapy.read more
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Fibronectin in malignancy: Cancer-specific alterations, protumoral effects, and therapeutic implications.
Jonathan Rick,Ankush Chandra,Cecilia L Dalle Ore,Alan T. Nguyen,Garima Yagnik,Manish K. Aghi +5 more
TL;DR: Fundamental studies that have investigated the impact of fibronectin in cancer are presented and it is shown that understanding the effect of this molecule has the potential to elucidate cancer biology.
Journal ArticleDOI
Cancer-associated fibroblasts enhance cell proliferation and metastasis of colorectal cancer SW480 cells by provoking long noncoding RNA UCA1
TL;DR: Results support the hypothesis that CAFs may be a prominent therapeutic target of stroma-based therapy in CRC treatment and highlight the vital role of cooperation between lncRNA UCA1 and mTOR in proliferation and metastasis.
Journal ArticleDOI
Tumor-Associated Fibroblasts Promote HER2-Targeted Therapy Resistance through FGFR2 Activation
Patricia Fernández-Nogueira,Mario Mancino,Gemma Fuster,Anna López-Plana,Patricia Jauregui,Vanessa Almendro,Estel Enreig,Silvia Menendez,Federico Rojo,Aleix Noguera-Castells,Anke Bill,L. Alex Gaither,Laia Serrano,Leire Recalde-Percaz,Núria Moragas,Raul Alonso,Elisabet Ametller,Ana Rovira,Ana Lluch,Joan Albanell,Pere Gascón,Paloma Bragado +21 more
TL;DR: The TAF/FGF5/FGFR2/c-Src/HER2 axis is identified as an escape pathway responsible for HER2-targeted therapy resistance in breast cancer, which can be reversed by FGFR inhibitors.
Journal ArticleDOI
The Complex Interaction between the Tumor Micro-Environment and Immune Checkpoints in Breast Cancer.
TL;DR: This work focuses on the immune checkpoint and TME elements that influence cancer progression, particularly studies in molecular subtypes of breast cancer.
Book ChapterDOI
Matrix Metalloproteinases' Role in Tumor Microenvironment.
TL;DR: The aim of the present chapter is to discuss MMPs' contribution to the evolution of cancer cells, their cellular origin, and their influence in the main processes that take place in the TME.
References
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