Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth.
Kazuyoshi Shiga,Masayasu Hara,Takaya Nagasaki,Takafumi Sato,Hiroki Takahashi,Hiromitsu Takeyama +5 more
TLDR
It is shown that CAFs are an important IL-6 source and that anti-IL-6 receptor antibody suppressed angiogenesis and inhibited tumor-stroma interactions, and CAFs contribute to drug-resistance acquisition in cancer cells.Abstract:
Cancer tissues are composed of cancer cells and the surrounding stromal cells (e.g., fibroblasts, vascular endothelial cells, and immune cells), in addition to the extracellular matrix. Most studies investigating carcinogenesis and the progression, invasion, metastasis, and angiogenesis of cancer have focused on alterations in cancer cells, including genetic and epigenetic changes. Recently, interactions between cancer cells and the stroma have attracted considerable attention, and increasing evidence has accumulated on this. Several researchers have gradually clarified the origins, features, and roles of cancer-associated fibroblasts (CAFs), a major component of the cancer stroma. CAFs function in a similar manner to myofibroblasts during wound healing. We previously reported the relationship between CAFs and angiogenesis. Interleukin-6 (IL-6), a multifunctional cytokine, plays a central role in regulating inflammatory and immune responses, and important roles in the progression, including proliferation, migration, and angiogenesis, of several cancers. We showed that CAFs are an important IL-6 source and that anti-IL-6 receptor antibody suppressed angiogenesis and inhibited tumor-stroma interactions. Furthermore, CAFs contribute to drug-resistance acquisition in cancer cells. The interaction between cancer cells and the stroma could be a potential target for anti-cancer therapy.read more
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A peek into cancer-associated fibroblasts: origins, functions and translational impact
Valerie S. LeBleu,Raghu Kalluri +1 more
TL;DR: Cancer-associated fibroblasts constitute a functionally heterogeneous mesenchymal cell population in the tumor microenvironment that orchestrates the interplay between the cancer cells and the host stromal response.
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Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives.
Xiaoqi Mao,Jin Xu,Wei Wang,Chen Liang,Jie Hua,Jiang Liu,Bo Zhang,Qingcai Meng,Xianjun Yu,Si Shi +9 more
TL;DR: Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of the tumor microenvironment (TME). Through multiple pathways, activated CAFs can promote tumor growth, angiogenesis, invasion and metastasis, along with extracellular matrix remodeling and even chemoresistance.
Journal ArticleDOI
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma.
David J. Clark,Saravana M. Dhanasekaran,Francesca Petralia,Jianbo Pan,Xiaoyu Song,Yingwei Hu,Felipe da Veiga Leprevost,Boris Reva,Tung-Shing M. Lih,Hui Yin Chang,Weiping Ma,Chen Huang,Christopher J. Ricketts,Lijun Chen,Azra Krek,Yize Li,Dmitry Rykunov,Qing Kay Li,Lin Chen,Umut Ozbek,Suhas Vasaikar,Yige Wu,Seungyeul Yoo,Shrabanti Chowdhury,Matthew A. Wyczalkowski,Jiayi Ji,Michael Schnaubelt,Andy T. Kong,Sunantha Sethuraman,Dmitry M. Avtonomov,Minghui Ao,Antonio Colaprico,Song Cao,Kyung-Cho Cho,Selim Kalayci,Shiyong Ma,Wenke Liu,Kelly V. Ruggles,Anna Calinawan,Zeynep H. Gümüş,Daniel J. Geiszler,Emily Kawaler,Guo Ci Teo,Bo Wen,Yuping Zhang,Sarah Keegan,Kai Li,Feng Chen,Nathan Edwards,Phillip M. Pierorazio,Xi Steven Chen,Christian P. Pavlovich,A. Ari Hakimi,Gabriel Bromiński,James J. Hsieh,Andrzej Antczak,Tatiana Omelchenko,Jan Lubinski,Maciej Wiznerowicz,Maciej Wiznerowicz,W. Marston Linehan,Christopher R. Kinsinger,Mathangi Thiagarajan,Emily S. Boja,Mehdi Mesri,Tara Hiltke,Ana I. Robles,Henry Rodriguez,Jiang Qian,David Fenyö,Bing Zhang,Li Ding,Eric E. Schadt,Arul M. Chinnaiyan,Zhen Zhang,Gilbert S. Omenn,Marcin Cieslik,Daniel W. Chan,Alexey I. Nesvizhskii,Pei Wang,Hui Zhang,Abdul Samad Hashimi,Alexander R. Pico,Alla Y. Karpova,Alyssa Charamut,Amanda G. Paulovich,Amy M. Perou,Anna Malovannaya,Annette Marrero-Oliveras,Anupriya Agarwal,Barbara Hindenach,Barbara Pruetz,Beom-Jun Kim,Brian J. Druker,Chelsea J. Newton,Chet Birger,Corbin D. Jones,Cristina E. Tognon,D. R. Mani,Dana R. Valley,Daniel C. Rohrer,Daniel C. Zhou,Darlene Tansil,David Chesla,David I. Heiman,David C. Wheeler,Donghui Tan,Doug W. Chan,Emek Demir,Ewa P. Malc,Francesmary Modugno,Gaddy Getz,Galen Hostetter,George D. Wilson,Gerald W. Hart,Heng Zhu,Hongwei Liu,Houston Culpepper,Hua Sun,Hua Zhou,Jacob J. Day,James Suh,Jasmine Huang,Jason E. McDermott,Jeffrey R. Whiteaker,Jeffrey W. Tyner,Jennifer M. Eschbacher,Jin Chen,John McGee,Jun Zhu,Karen A. Ketchum,Karin D. Rodland,Karl R. Clauser,Karna Robinson,Karsten Krug,Katherine A. Hoadley,Ki Sung Um,Kim Elburn,Kimberly R. Holloway,Liang-Bo Wang,Lili Blumenberg,Linda Hannick,Liqun Qi,Lori J. Sokoll,MacIntosh Cornwell,Marc M. Loriaux,Marcin J. Domagalski,Marina A. Gritsenko,Matthew L. Anderson,Matthew E. Monroe,Matthew J. Ellis,Maureen Dyer,Meenakshi Anurag,Meghan C. Burke,Melissa Borucki,Michael A. Gillette,Michael J. Birrer,Michael T. Lewis,Michael Ittmann,Michael Smith,Michael Vernon,Michelle Chaikin,Milan G. Chheda,Munziba Khan,Nancy Roche,Nathan Edwards,Negin Vatanian,Nicole Tignor,Noam D. Beckmann,Pamela Grady,Patricia Castro,Paul D. Piehowski,Peter B. McGarvey,Piotr A. Mieczkowski,Pushpa Hariharan,Qingsong Gao,Rajiv Dhir,Ramani B. Kothadia,Ratna R. Thangudu,Rebecca I. Montgomery,Reyka G Jayasinghe,Richard D. Smith,Robert Edwards,Robert Zelt,Ross Bremner,Ruiyang Liu,Runyu Hong,Sailaja Mareedu,Samuel H. Payne,Sandra Cottingham,Sanford P. Markey,Scott D. Jewell,Shalin Patel,Shankha Satpathy,Shannon Richey,Sherri R. Davies,Shuang Cai,Simina M. Boca,Snehal Patil,Sohini Sengupta,Sonya Carter,Stacey Gabriel,Stefani N. Thomas,Stephanie De Young,Stephen E. Stein,Steven A. Carr,Steven M. Foltz,Sue Hilsenbeck,Tanya Krubit,Tao Liu,Tara Skelly,Thomas F. Westbrook,Uma Borate,Uma Velvulou,Vladislav A. Petyuk,William Bocik,Xi Chen,Yan Shi,Yifat Geffen,Yihao Lu,Ying Wang,Yosef E. Maruvka,Zhi Li,Zhiao Shi,Zhidong Tu +224 more
TL;DR: A large-scale proteogenomic analysis of ccRCC is reported to discern the functional impact of genomic alterations and provides evidence for rational treatment selection stemming fromccRCC pathobiology.
Journal ArticleDOI
Recent Advances in Cell Membrane-Camouflaged Nanoparticles for Cancer Phototherapy.
Xu Zhen,Penghui Cheng,Kanyi Pu +2 more
TL;DR: This review summarizes the recent advances in the development of biomimetic cell membrane-camouflaged nanoparticles for cancer phototherapy and suggests that combining other supplementary agents to normalize tumor microenvironment can further enhance the therapeutic efficacy against cancer.
Journal ArticleDOI
Cancer-Associated Fibroblasts Build and Secure the Tumor Microenvironment.
TL;DR: A better understanding of the complexities ofCAF-ECM and CAF-cancer cell interactions is necessary before novel therapeutic strategies targeting the malignant tumor “soil” can be successfully implemented in the clinic.
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