CCR2+ monocytes infiltrate atrophic lesions in age‐related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice
Florian Sennlaub,Constance Auvynet,Constance Auvynet,Bertrand Calippe,Sophie Lavalette,Lucie Poupel,Lucie Poupel,Shulong J. Hu,Elisa Dominguez,Serge Camelo,Olivier Levy,Elodie Guyon,Elodie Guyon,Noah Saederup,Israel F. Charo,Nico van Rooijen,Emeline F. Nandrot,Jean-Louis Bourges,Francine Behar-Cohen,José-Alain Sahel,Xavier Guillonneau,William Raoul,Christophe Combadière,Christophe Combadière +23 more
TLDR
It is shown that atrophic AMD is associated with increased intraocular CCL2 levels and subretinal CCR2+ inflammatory monocyte infiltration in patients and CCL/CCR2 inhibition might represent a powerful tool for controlling inflammation and neurodegeneration in AMD.Citations
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Inflammation and its role in age-related macular degeneration
TL;DR: Elevations in levels of local and systemic biomarkers indicate that chronic inflammation is involved in the pathogenesis of both disease forms of age-related macular degeneration.
Journal ArticleDOI
Retinal microglia: Just bystander or target for therapy?
TL;DR: It is concluded that this resident immune cell of the retina cannot be simply regarded as bystander of disease but may instead be a potential therapeutic target to be modulated in the treatment of degenerative and inflammatory diseases ofThe retina.
Journal ArticleDOI
Parainflammation, chronic inflammation, and age-related macular degeneration
TL;DR: The basic principles of retinal innate‐immune responses to endogenous chronic insults in normal aging and in age-related macular degeneration are discussed and the difference between beneficial parainflammation and the detrimental chronic inflammation is explored in the context of age‐related macularity degeneration.
Journal ArticleDOI
Microglia in Retinal Degeneration.
TL;DR: This review provides an overview of recent studies that depict microglial responses in diverse retinal pathologies that have degeneration and chronic immune reactions as key pathophysiological components and discusses innovative immunomodulatory therapy strategies that dampen the detrimental immunological responses to improve disease outcome.
Journal ArticleDOI
Contribution of microglia-mediated neuroinflammation to retinal degenerative diseases.
TL;DR: An overview of the roles of microglia-mediated neuroinflammation in major retinal degenerative diseases like glaucoma, age-related macular degeneration, and diabetic retinopathy is given.
References
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The chemokine system in diverse forms of macrophage activation and polarization.
Alberto Mantovani,Alberto Mantovani,Antonio Sica,Silvano Sozzani,Silvano Sozzani,Paola Allavena,Annunciata Vecchi,Massimo Locati +7 more
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Complement Factor H Polymorphism in Age-Related Macular Degeneration
Robert J. Klein,Caroline J. Zeiss,Emily Y. Chew,Jen-yue Tsai,Richard S. Sackler,Chad Haynes,A. K. Henning,John Paul SanGiovanni,Shrikant Mane,Susan T. Mayne,Michael B. Bracken,Frederick L. Ferris,Jurg Ott,Colin J. Barnstable,Josephine Hoh +14 more
TL;DR: A genome-wide screen for polymorphisms associated with age-related macular degeneration revealed a polymorphism in linkage disequilibrium with the risk allele representing a tyrosine-histidine change at amino acid 402 in the complement factor H gene.
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Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Florent Ginhoux,Florent Ginhoux,Melanie Greter,Marylene Leboeuf,Sayan Nandi,Peter See,Solen Gokhan,Mark F. Mehler,Simon J. Conway,Lai Guan Ng,E. Richard Stanley,Igor M. Samokhvalov,Miriam Merad +12 more
TL;DR: Results identify microglia as an ontogenically distinct population in the mononuclear phagocyte system and have implications for the use of embryonically derived microglial progenitors for the treatment of various brain disorders.
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Macrophage biology in development, homeostasis and disease
TL;DR: This Review discusses how macrophage regulate normal physiology and development, and provides several examples of their pathophysiological roles in disease, and defines the ‘hallmarks’ of macrophages according to the states that they adopt during the performance of their various roles.
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Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
TL;DR: Using a murine adoptive transfer system to probe monocyte homing and differentiation in vivo, two functional subsets among murine blood monocytes are identified: a short-lived CX(3)CR1(lo)CCR2(+)Gr1(+) subset that is actively recruited to inflamed tissues and a CX (3) CR1(hi)CCS1-dependent recruitment to noninflamed tissues.
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CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration
Christophe Combadière,Charles Feumi,William Raoul,Nicole Keller,Mathieu P Rodero,Adeline Pezard,Sophie Lavalette,Marianne Houssier,Laurent Jonet,Emilie Picard,Patrice Debré,Mirna Sirinyan,Philippe Deterre,Tania Ferroukhi,Salomon-Yves Cohen,Dominique Chauvaud,Jean-Claude Jeanny,Sylvain Chemtob,Francine Behar-Cohen,Florian Sennlaub +19 more