Journal ArticleDOI
Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer
Arlene A. Forastiere,Helmuth Goepfert,Moshe H. Maor,Thomas F. Pajak,Randal S. Weber,William H. Morrison,Bonnie S. Glisson,Andy Trotti,John A. Ridge,C. Chao,Glen Peters,Ding Jen Lee,Andrea Leaf,John F. Ensley,Jay S. Cooper +14 more
TLDR
In patients with laryngeal cancer, radiotherapy with concurrent administration of cisplatin is superior to induction chemotherapy followed by radiotherapy or radiotherapy alone for larynGEal preservation and locoregional control.Abstract:
Background Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients with locally advanced laryngeal cancer. The value of adding chemotherapy to radiotherapy and the optimal timing of chemotherapy are unknown. Methods We randomly assigned patients with locally advanced cancer of the larynx to one of three treatments: induction cisplatin plus fluorouracil followed by radiotherapy, radiotherapy with concurrent administration of cisplatin, or radiotherapy alone. The primary end point was preservation of the larynx. Results A total of 547 patients were randomly assigned to one of the three study groups. The median follow-up period was 3.8 years. At two years, the proportion of patients who had an intact larynx after radiotherapy with concurrent cisplatin (88 percent) differed significantly from the proportions in the groups given induction chemotherapy followed by radiotherapy (75 percent, P=0.005) or radiotherapy alone (70 ...read more
Citations
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Journal ArticleDOI
Concurrent platinum-based chemotherapy and simultaneous modulated accelerated radiation therapy for locally advanced squamous cell carcinoma of the tongue base.
Joshua D. Lawson,Kristen B. Otto,Amy Y. Chen,Dong M. Shin,Lawrence W. Davis,Peter A.S. Johnstone +5 more
TL;DR: Outcomes data are presented using simultaneous modulated accelerated radiation therapy (SMART) combined with platinum‐based chemotherapy in treatment of locally advanced SCC of the BOT.
Journal ArticleDOI
Concurrent Chemotherapy and Re-irradiation for Locoregionally Recurrent Head and Neck Cancer
TL;DR: The basis for current chemoradiotherapy (CRT) regimens used in previously radiated patients, focusing on outcome and toxicity are reviewed, and controversies, such as the utility of chemotherapy and RRT following surgical salvage, are addressed.
Journal ArticleDOI
Primary and Salvage Total Laryngectomy
TL;DR: The role of total laryngectomy is not extinct and still plays an important role in primary therapy for advanced stagelaryngeal cancers and as salvage therapy for failures of organ preservation strategies.
Journal ArticleDOI
Primary radiotherapy compared with primary surgery in cervical esophageal cancer.
Cai Neng Cao,Jing Wei Luo,Li Gao,G. Xu,Jun Lin Yi,Xiaodong Huang,Su Yan Li,Jian Ping Xiao,Shao Yan Liu,Zhen Gang Xu,Ping Zhang Tang +10 more
TL;DR: Given the similarities in rates of local failure-free survival, regional FFS, distant F FS, and overall survival between the primary RT and primary surgery CEC treatment groups, it is recommended primary RT for larynx preservation, with surgery offered subsequently for patients who do not respond to RT.
Journal ArticleDOI
Effectiveness of chemoradiation for head and neck cancer in an older patient population.
Noam A. VanderWalde,Anne Marie Meyer,Allison M. Deal,J. Bradley Layton,Huan Liu,William R. Carpenter,Mark C. Weissler,David N. Hayes,Mary Fleming,Bhishamjit S. Chera +9 more
TL;DR: Although the addition of chemotherapy to radiation has proven efficacious in many randomized controlled trials, it may be less effective in an older patient population treated outside of a controlled trial setting.
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