Journal ArticleDOI
Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer
Arlene A. Forastiere,Helmuth Goepfert,Moshe H. Maor,Thomas F. Pajak,Randal S. Weber,William H. Morrison,Bonnie S. Glisson,Andy Trotti,John A. Ridge,C. Chao,Glen Peters,Ding Jen Lee,Andrea Leaf,John F. Ensley,Jay S. Cooper +14 more
TLDR
In patients with laryngeal cancer, radiotherapy with concurrent administration of cisplatin is superior to induction chemotherapy followed by radiotherapy or radiotherapy alone for larynGEal preservation and locoregional control.Abstract:
Background Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients with locally advanced laryngeal cancer. The value of adding chemotherapy to radiotherapy and the optimal timing of chemotherapy are unknown. Methods We randomly assigned patients with locally advanced cancer of the larynx to one of three treatments: induction cisplatin plus fluorouracil followed by radiotherapy, radiotherapy with concurrent administration of cisplatin, or radiotherapy alone. The primary end point was preservation of the larynx. Results A total of 547 patients were randomly assigned to one of the three study groups. The median follow-up period was 3.8 years. At two years, the proportion of patients who had an intact larynx after radiotherapy with concurrent cisplatin (88 percent) differed significantly from the proportions in the groups given induction chemotherapy followed by radiotherapy (75 percent, P=0.005) or radiotherapy alone (70 ...read more
Citations
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Journal ArticleDOI
Neoadjuvant chemotherapy in head and neck cancer: Should it be revisited?
Pol Specenier,Jan B. Vermorken +1 more
TL;DR: New challenges are the integration of targeted therapies into the current treatment strategies and the identification of prognostic biomarkers and of factors predicting the response to treatment which would help to select patients who are likely to benefit most from induction chemotherapy.
Journal ArticleDOI
Volumetric modulated arc therapy for treatment of solid tumors: current insights.
Gabriella Macchia,Francesco Deodato,Savino Cilla,Silvia Cammelli,Alessandra Guido,Martina Ferioli,Giambattista Siepe,Vincenzo Valentini,Alessio G. Morganti,Gabriella Ferrandina,Gabriella Ferrandina +10 more
TL;DR: Current literature suggests that VMAT, especially when used as simultaneous integrated boost or SBRT strategy, is an effective safe modality for all cancer types.
Journal ArticleDOI
Evaluation of Hyperpolarized [1-13C]-Pyruvate by Magnetic Resonance to Detect Ionizing Radiation Effects in Real Time
Vlad C. Sandulache,Yunyun Chen,Jaehyuk Lee,A Rubinstein,Marc S. Ramirez,Heath D. Skinner,Christopher M. Walker,Michelle D. Williams,Ramesh C. Tailor,Laurence E. Court,James A. Bankson,Stephen Y. Lai +11 more
TL;DR: This work has adapted HP-MRS/MRSI to non-invasively measure IR mediated changes in tumor reducing potential in real time to facilitate the development of an adaptive clinical algorithm based on real-time adjustments in IR dose and dose mapping.
Journal ArticleDOI
Current Management of Locally Advanced Head and Neck Cancer: The Combination of Chemotherapy With Locoregional Treatments
Voichita Bar-Ad,Joshua D. Palmer,Hushan Yang,David Cognetti,Joseph Curry,Adam Luginbuhl,Madalina Tuluc,Barbara G. Campling,Rita Axelrod +8 more
TL;DR: The evolution of the role of chemotherapy in the treatment of locally advanced head and neck cancer (HNC), over the last few decades is discussed.
Journal ArticleDOI
Supracricoid partial laryngectomy in the management of t3 laryngeal cancer.
Giuseppe Mercante,Alberto Grammatica,Paolo Battaglia,Giovanni Cristalli,Raul Pellini,Giuseppe Spriano +5 more
TL;DR: Supracricoid partial laryngectomy for selected glottic and supraglottic T3 tumors has excellent oncologic and functional results.
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