Journal ArticleDOI
Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer
Arlene A. Forastiere,Helmuth Goepfert,Moshe H. Maor,Thomas F. Pajak,Randal S. Weber,William H. Morrison,Bonnie S. Glisson,Andy Trotti,John A. Ridge,C. Chao,Glen Peters,Ding Jen Lee,Andrea Leaf,John F. Ensley,Jay S. Cooper +14 more
TLDR
In patients with laryngeal cancer, radiotherapy with concurrent administration of cisplatin is superior to induction chemotherapy followed by radiotherapy or radiotherapy alone for larynGEal preservation and locoregional control.Abstract:
Background Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients with locally advanced laryngeal cancer. The value of adding chemotherapy to radiotherapy and the optimal timing of chemotherapy are unknown. Methods We randomly assigned patients with locally advanced cancer of the larynx to one of three treatments: induction cisplatin plus fluorouracil followed by radiotherapy, radiotherapy with concurrent administration of cisplatin, or radiotherapy alone. The primary end point was preservation of the larynx. Results A total of 547 patients were randomly assigned to one of the three study groups. The median follow-up period was 3.8 years. At two years, the proportion of patients who had an intact larynx after radiotherapy with concurrent cisplatin (88 percent) differed significantly from the proportions in the groups given induction chemotherapy followed by radiotherapy (75 percent, P=0.005) or radiotherapy alone (70 ...read more
Citations
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Journal ArticleDOI
Multi-agent concurrent chemoradiotherapy for locally advanced head and neck squamous cell cancer in the elderly.
Stephanie A. Michal,David J. Adelstein,Lisa Rybicki,Cristina P. Rodriguez,Jerrold P. Saxton,Benjamin G. Wood,Joseph Scharpf,Denise I. Ives +7 more
TL;DR: The reported decreasing benefit with increasing age from concurrent chemoradiotherapy in head and neck cancer patients prompted this retrospective review.
Journal ArticleDOI
Therapeutic exercises for affecting post-treatment swallowing in people treated for advanced-stage head and neck cancers.
TL;DR: This paper found no evidence that therapeutic exercises were better than TAU, or any other treatment, in improving the safety and efficiency of oral swallowing (our primary outcome) or in improving any of the secondary outcomes.
Journal ArticleDOI
Benefits and drawbacks of open partial horizontal laryngectomies, Part B: Intermediate and selected advanced stage laryngeal carcinoma.
Giovanni Succo,Erika Crosetti,Andy Bertolin,Marco Lucioni,Giulia Arrigoni,Valentina Panetta,Andrea Elio Sprio,Giovanni Nicolao Berta,Giuseppe Rizzotto +8 more
TL;DR: Open partial horizontal laryngectomy is proposed as a function‐sparing surgical technique for cancer of the larynx in the intermediate/advanced stage.
Journal ArticleDOI
XPF expression correlates with clinical outcome in squamous cell carcinoma of the head and neck
Alec Vaezi,Xiao Zhe Wang,Shama Buch,William E. Gooding,Lin Wang,Raja R. Seethala,David T. Weaver,Alan D. D'Andrea,Athanassios Argiris,Marjorie Romkes,Laura J. Niedernhofer,Jennifer R. Grandis +11 more
TL;DR: In this article, the expression level of the XPF gene in head and neck squamous cell carcinoma (HNSCC) was found to correlate with clinical response to DNA damaging agents.
Journal ArticleDOI
Phase I Study of C-TPF in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck
Robert I. Haddad,Roy B. Tishler,Charles M. Norris,Laura A. Goguen,Tracy A. Balboni,Rosemary Costello,Lori J. Wirth,Jochen H. Lorch,Britta Andreozzi,Donald J. Annino,Marshall R. Posner +10 more
TL;DR: Reducing the FU in TPF to 850 mg/m(2) reduces GI toxicity and is the recommended phase II dose and C-TPF appears to be safe and feasible as given.
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