Journal ArticleDOI
Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer
Arlene A. Forastiere,Helmuth Goepfert,Moshe H. Maor,Thomas F. Pajak,Randal S. Weber,William H. Morrison,Bonnie S. Glisson,Andy Trotti,John A. Ridge,C. Chao,Glen Peters,Ding Jen Lee,Andrea Leaf,John F. Ensley,Jay S. Cooper +14 more
TLDR
In patients with laryngeal cancer, radiotherapy with concurrent administration of cisplatin is superior to induction chemotherapy followed by radiotherapy or radiotherapy alone for larynGEal preservation and locoregional control.Abstract:
Background Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients with locally advanced laryngeal cancer. The value of adding chemotherapy to radiotherapy and the optimal timing of chemotherapy are unknown. Methods We randomly assigned patients with locally advanced cancer of the larynx to one of three treatments: induction cisplatin plus fluorouracil followed by radiotherapy, radiotherapy with concurrent administration of cisplatin, or radiotherapy alone. The primary end point was preservation of the larynx. Results A total of 547 patients were randomly assigned to one of the three study groups. The median follow-up period was 3.8 years. At two years, the proportion of patients who had an intact larynx after radiotherapy with concurrent cisplatin (88 percent) differed significantly from the proportions in the groups given induction chemotherapy followed by radiotherapy (75 percent, P=0.005) or radiotherapy alone (70 ...read more
Citations
More filters
Journal ArticleDOI
Long-term outcomes after surgical or nonsurgical initial therapy for patients with T4 squamous cell carcinoma of the larynx: A 3-decade survey
David I. Rosenthal,Abdallah S.R. Mohamed,Randal S. Weber,Adam S. Garden,Parag R. Sevak,Parag R. Sevak,Merril S. Kies,William H. Morrison,Jan S. Lewin,Adel K. El-Naggar,Lawrence E. Ginsberg,Esengul Kocak-Uzel,K. Kian Ang,Clifton D. Fuller +13 more
TL;DR: The current study was conducted to evaluate long‐term disease control, survival, and functional outcomes after surgical and nonsurgical initial treatment for patients with T4 larynx cancer.
Journal ArticleDOI
Amplicon mapping and expression profiling identify the fas-associated death domain gene as a new driver in the 11q13.3 amplicon in Laryngeal/Pharyngeal cancer
Johan H. Gibcus,Lorian Menkema,Mirjam F. Mastik,Mario Hermsen,Geertruida H. de Bock,Marie-Louise F. van Velthuysen,Robert P. Takes,Klaas Kok,Cesar A. Álvarez Marcos,Bernard F. A. M. van der Laan,Michiel W. M. van den Brekel,Johannes A. Langendijk,Philip M. Kluin,Jacqueline E. van der Wal,Ed Schuuring +14 more
TL;DR: It is hypothesized that FADD is a marker to select patients that might benefit from Taxol-based chemoradiotherapy because of the frequent amplification of the 11q13 region and concomitant overexpression of FADD in head and neck squamous cell carcinomas.
Journal ArticleDOI
PET-CT for radiotherapy treatment planning and response monitoring in solid tumors
TL;DR: PET imaging has evolved as an indispensible tool for staging in oncology, enabling clinicians to select patients for intensified treatment on the basis of resistance mechanisms taking place at the molecular level.
Journal ArticleDOI
Salvage surgery after concomitant chemoradiation in head and neck squamous cell carcinomas - stratification for postsalvage survival.
TL;DR: Salvage surgery after concomitant chemoradiation therapy for patients with head and neck squamous cell carcinomas (HNSCC) is challenging because of its associated morbidity/mortality and the poor prognoses of these patients.
Journal ArticleDOI
The role of neck dissection in the setting of chemoradiation therapy for head and neck squamous cell carcinoma with advanced neck disease
Marc Hamoir,Alfio Ferlito,Sandra Schmitz,François-Xavier Hanin,Juliette Thariat,Birgit Weynand,Jean-Pascal Machiels,Vincent Grégoire,K. Thomas Robbins,Carl E. Silver,Primož Strojan,Alessandra Rinaldo,June Corry,Robert P. Takes +13 more
TL;DR: It is concluded that planned ND is not necessary for patients with complete response because of the availability of improved diagnostic follow up modalities, and the increased sensitivity to CRT of HNSCC, particularly HPV associated tumors.
References
More filters
Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Journal Article
Evaluation of survival data and two new rank order statistics arising in its consideration.
Journal ArticleDOI
A Multiple Comparison Procedure for Comparing Several Treatments with a Control
TL;DR: In this article, a multiple comparison procedure for comparing several treatments with a control is presented, which is based on the Multiple Comparison Procedure for Comparing Several Treatments with a Control (MCPC).
Journal ArticleDOI
A Class of $K$-Sample Tests for Comparing the Cumulative Incidence of a Competing Risk
TL;DR: In this paper, a class of tests developed for comparing the cumulative incidence of a particular type of failure among different groups is presented. The tests are based on comparing weighted averages of the hazards of the subdistribution for the failure type of interest.
Journal ArticleDOI
Cancer statistics, 2003.
TL;DR: The American Cancer Society estimates the number of new cancer cases and deaths expected in the United States in the current year, and compiles the most recent data on cancer incidence, mortality, and survival by using incidence data from the National Cancer Institute (NCI) and mortality data from National Center for Health Statistics (NCHS).