Journal ArticleDOI
Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer
Arlene A. Forastiere,Helmuth Goepfert,Moshe H. Maor,Thomas F. Pajak,Randal S. Weber,William H. Morrison,Bonnie S. Glisson,Andy Trotti,John A. Ridge,C. Chao,Glen Peters,Ding Jen Lee,Andrea Leaf,John F. Ensley,Jay S. Cooper +14 more
TLDR
In patients with laryngeal cancer, radiotherapy with concurrent administration of cisplatin is superior to induction chemotherapy followed by radiotherapy or radiotherapy alone for larynGEal preservation and locoregional control.Abstract:
Background Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients with locally advanced laryngeal cancer. The value of adding chemotherapy to radiotherapy and the optimal timing of chemotherapy are unknown. Methods We randomly assigned patients with locally advanced cancer of the larynx to one of three treatments: induction cisplatin plus fluorouracil followed by radiotherapy, radiotherapy with concurrent administration of cisplatin, or radiotherapy alone. The primary end point was preservation of the larynx. Results A total of 547 patients were randomly assigned to one of the three study groups. The median follow-up period was 3.8 years. At two years, the proportion of patients who had an intact larynx after radiotherapy with concurrent cisplatin (88 percent) differed significantly from the proportions in the groups given induction chemotherapy followed by radiotherapy (75 percent, P=0.005) or radiotherapy alone (70 ...read more
Citations
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Journal ArticleDOI
Induction chemotherapy followed by radiotherapy for larynx preservation in advanced laryngeal and hypopharyngeal cancer: Outcome prediction after one cycle induction chemotherapy by a score based on clinical evaluation, computed tomography-based volumetry and 18F-FDG-PET/CT
Gunnar Wichmann,Anne Krüger,Andreas Boehm,Marlen Kolb,Mathias Hofer,M. Fischer,Stefan Müller,Sandra Purz,Patrick Stumpp,Osama Sabri,Andreas Dietz,Regine Kluge +11 more
TL;DR: LFS-score ≤ 16 identifies in responders to IC-1 the patients with maximum benefit of non-surgical larynx preservation achieving long-term LFS and predicts increased LFS, OS and TSS.
Journal ArticleDOI
Should elective neck dissection be routinely performed in patients undergoing salvage total laryngectomy
Thomas F. Pezier,Iain J. Nixon,William J Scotton,Anil Joshi,Teresa Guerrero-Urbano,Richard Oakley,Jean-Pierre Jeannon,Ricard Simo +7 more
TL;DR: Given the increased complications associated with neck dissection in the salvage setting, consideration should be given to conservative management of the neck in clinically node-negative patients (staged following primary radiotherapy or chemoradiotherapy).
Journal ArticleDOI
Neoadjuvant Systemic Chemotherapy in the Management of Extensive Eyelid Sebaceous Gland Carcinoma: A study of 10 Cases
Swathi Kaliki,Anuradha Ayyar,Akshay Gopinathan Nair,Dilip K Mishra,Vijay Anand P. Reddy,Milind N. Naik +5 more
TL;DR: Neoadjuvant systemic chemotherapy is effective and safe in the management of eyelid sebaceous gland carcinoma and one patient died due to systemic metastasis.
Journal ArticleDOI
Intratumoral dendritic cells and chemoradiation for the treatment of murine squamous cell carcinoma.
TL;DR: It is suggested that a possible role for the use of intratumoral dendritic cell therapy with more traditional chemoradiation strategies is suggested, as well as the ability of concurrent systemic chemotherapy and local, fractionated radiation to augment intratum Oral Dendritic Cell injections in a mouse model of squamous cell carcinoma.
Journal ArticleDOI
The Indian scenario of head and neck oncology - Challenging the dogmas.
Vidisha Tuljapurkar,Harsh Dhar,Aseem Mishra,Swagnik Chakraborti,Pankaj Chaturvedi,Prathamesh S. Pai +5 more
TL;DR: A literature search is performed to find noteworthy Indian studies that changed practice of HNC as well as to look for areas for further research in this field.
References
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