Journal ArticleDOI
Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer
Arlene A. Forastiere,Helmuth Goepfert,Moshe H. Maor,Thomas F. Pajak,Randal S. Weber,William H. Morrison,Bonnie S. Glisson,Andy Trotti,John A. Ridge,C. Chao,Glen Peters,Ding Jen Lee,Andrea Leaf,John F. Ensley,Jay S. Cooper +14 more
TLDR
In patients with laryngeal cancer, radiotherapy with concurrent administration of cisplatin is superior to induction chemotherapy followed by radiotherapy or radiotherapy alone for larynGEal preservation and locoregional control.Abstract:
Background Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients with locally advanced laryngeal cancer. The value of adding chemotherapy to radiotherapy and the optimal timing of chemotherapy are unknown. Methods We randomly assigned patients with locally advanced cancer of the larynx to one of three treatments: induction cisplatin plus fluorouracil followed by radiotherapy, radiotherapy with concurrent administration of cisplatin, or radiotherapy alone. The primary end point was preservation of the larynx. Results A total of 547 patients were randomly assigned to one of the three study groups. The median follow-up period was 3.8 years. At two years, the proportion of patients who had an intact larynx after radiotherapy with concurrent cisplatin (88 percent) differed significantly from the proportions in the groups given induction chemotherapy followed by radiotherapy (75 percent, P=0.005) or radiotherapy alone (70 ...read more
Citations
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Journal ArticleDOI
Swallowing dysfunction is a common sequelae after chemoradiation for oropharynx carcinoma.
Kathryn M. Greven,Douglas R. White,J. Dale Browne,Daniel W. Williams,W. Fred Mcguirt,Ralph B. D'Agostino +5 more
TL;DR: The most notable difference in sequelae between the 2 groups was the increase in swallowing dysfunction with concurrent chemotherapy, which decreases the recurrence at the primary site and above the clavicles.
Journal ArticleDOI
Longitudinal oncology registry of head and neck carcinoma (LORHAN)
Stuart J. Wong,Paul M. Harari,Adam S. Garden,Marc Schwartz,Lisa A. Bellm,Amy Y. Chen,Walter J. Curran,Barbara A. Murphy,K. Kian Ang +8 more
TL;DR: A study was undertaken to examine the patterns of systemic therapy use in conjunction with radiation therapy for patients with locally advanced head and neck squamous cell cancer.
Journal ArticleDOI
Concomitant weekly cisplatin and altered fractionation radiotherapy in locally advanced head and neck cancer.
Heather E. Newlin,Robert J. Amdur,Charles E. Riggs,Christopher G. Morris,Jessica Kirwan,William M. Mendenhall +5 more
TL;DR: The authors' purpose was to report efficacy and toxicity after weekly cisplatin (30 mg/m2/wk) concurrent with altered fractionation RT.
Journal ArticleDOI
Cisplatin versus Cetuximab Given Concurrently with Definitive Radiation Therapy for Locally Advanced Head and Neck Squamous Cell Carcinoma
Jessica Ley,Paul Mehan,Tanya M. Wildes,Wade L. Thorstad,Loren S. Michel,Brian Nussenbaum,Kathryn Trinkaus,Douglas Adkins +7 more
TL;DR: DSS was superior in the patients given cisplatin with definitiveRT compared to cetuximab with definitive RT due to a lower risk of recurrent disease in the cis platin group, and could not be explained by differences between the two groups in the patient and tumor characteristics or in treatment delivery.
Journal ArticleDOI
Treatment-Related Toxicities in Older Adults with Head and Neck Cancer: A Population-Based Analysis
Caitriona B. O'Neill,Shrujal S. Baxi,Coral L. Atoria,James P. O'Neill,Martin Henman,Eric J. Sherman,Nancy Y. Lee,David G. Pfister,Elena B. Elkin +8 more
TL;DR: Assessment of types and frequencies of toxicities in older adults with locally or regionally advanced head and neck squamous cell carcinoma who were receiving either primary CTRT or radiation therapy (RT) alone.
References
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