Journal ArticleDOI
Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer
Arlene A. Forastiere,Helmuth Goepfert,Moshe H. Maor,Thomas F. Pajak,Randal S. Weber,William H. Morrison,Bonnie S. Glisson,Andy Trotti,John A. Ridge,C. Chao,Glen Peters,Ding Jen Lee,Andrea Leaf,John F. Ensley,Jay S. Cooper +14 more
TLDR
In patients with laryngeal cancer, radiotherapy with concurrent administration of cisplatin is superior to induction chemotherapy followed by radiotherapy or radiotherapy alone for larynGEal preservation and locoregional control.Abstract:
Background Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients with locally advanced laryngeal cancer. The value of adding chemotherapy to radiotherapy and the optimal timing of chemotherapy are unknown. Methods We randomly assigned patients with locally advanced cancer of the larynx to one of three treatments: induction cisplatin plus fluorouracil followed by radiotherapy, radiotherapy with concurrent administration of cisplatin, or radiotherapy alone. The primary end point was preservation of the larynx. Results A total of 547 patients were randomly assigned to one of the three study groups. The median follow-up period was 3.8 years. At two years, the proportion of patients who had an intact larynx after radiotherapy with concurrent cisplatin (88 percent) differed significantly from the proportions in the groups given induction chemotherapy followed by radiotherapy (75 percent, P=0.005) or radiotherapy alone (70 ...read more
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Journal ArticleDOI
Oxygen-modifying treatment with ARCON reduces the prognostic significance of hemoglobin in squamous cell carcinoma of the head and neck.
Ilse J. Hoogsteen,Lucas A.M. Pop,Henri A. M. Marres,M.A.W. Merkx,Franciscus J.A. van den Hoogen,Albert J. van der Kogel,Johannes H.A.M. Kaanders +6 more
TL;DR: Hb level was not found to be of prognostic significance for outcome in patients with squamous cell carcinoma of the head and neck after oxygen-modifying treatment with ARCON.
Journal ArticleDOI
Oncologic and Functional Outcomes of Partial Laryngeal Surgery for Intermediate-Stage Laryngeal Cancer
Emiro Caicedo-Granados,Daniel M. Beswick,Apostolos Christopoulos,Diana E. Cunningham,Ali Razfar,James Ohr,Dwight E. Heron,Robert L. Ferris +7 more
TL;DR: PLS provides excellent oncologic and functional outcomes for intermediate-stage LSCC and should be considered an alternative to chemoradiation or total laryngectomy in selected patients.
Journal ArticleDOI
Chemoradiotherapy as Definitive Treatment for Elderly Patients with Head and Neck Cancer
Jens von der Grün,Daniel Martin,Timo Stöver,Shahram Ghanaati,Claus Rödel,Claus Rödel,Panagiotis Balermpas,Panagiotis Balermpas +7 more
TL;DR: Definitive treatment with CRT for SCCHN is feasible and effective; even in advanced age treatment decisions should be made according to general condition and comorbidity, rather than calendar age alone.
Journal ArticleDOI
Concurrent chemoradiotherapy for head and neck cancer
TL;DR: Results of phase II studies suggest that the addition of induction chemotherapy to CRT may further enhance outcome through eradication of systemic metastases, although this will require prospective evaluation in randomized clinical trials.
Journal ArticleDOI
Long-term functional results after open partial horizontal laryngectomy type IIa and type IIIa: A comparison study
Antonio Schindler,Nicole Pizzorni,Marco Fantini,Erika Crosetti,Andy Bertolin,Giuseppe Rizzotto,Giovanni Succo +6 more
TL;DR: The purpose of this study was to compare long‐term swallowing, voice results, and quality of life (QOL) after open partial horizontal laryngectomy (OPHL) type IIa and type IIIa.
References
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