Journal ArticleDOI
Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer
Arlene A. Forastiere,Helmuth Goepfert,Moshe H. Maor,Thomas F. Pajak,Randal S. Weber,William H. Morrison,Bonnie S. Glisson,Andy Trotti,John A. Ridge,C. Chao,Glen Peters,Ding Jen Lee,Andrea Leaf,John F. Ensley,Jay S. Cooper +14 more
TLDR
In patients with laryngeal cancer, radiotherapy with concurrent administration of cisplatin is superior to induction chemotherapy followed by radiotherapy or radiotherapy alone for larynGEal preservation and locoregional control.Abstract:
Background Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients with locally advanced laryngeal cancer. The value of adding chemotherapy to radiotherapy and the optimal timing of chemotherapy are unknown. Methods We randomly assigned patients with locally advanced cancer of the larynx to one of three treatments: induction cisplatin plus fluorouracil followed by radiotherapy, radiotherapy with concurrent administration of cisplatin, or radiotherapy alone. The primary end point was preservation of the larynx. Results A total of 547 patients were randomly assigned to one of the three study groups. The median follow-up period was 3.8 years. At two years, the proportion of patients who had an intact larynx after radiotherapy with concurrent cisplatin (88 percent) differed significantly from the proportions in the groups given induction chemotherapy followed by radiotherapy (75 percent, P=0.005) or radiotherapy alone (70 ...read more
Citations
More filters
Journal ArticleDOI
The role of laser microsurgery in the treatment of laryngeal cancer.
TL;DR: The role of laser microsurgical partial resections of the larynx in comparison with other treatment modalities is elucidated, finding that laser microsurgery is comparable to open supraglottic laryngectomy but superior to radiotherapy.
Journal ArticleDOI
HPV & head and neck cancer: a descriptive update
Peter Goon,Margaret Stanley,Jörg Ebmeyer,L. Steinsträsser,Tahwinder Upile,Waseem Jerjes,Manuel Bernal-Sprekelsen,Martin Görner,Holger Sudhoff +8 more
TL;DR: The improved prognosis and treatment responses to chemotherapy and radiotherapy by HPV+ tumours may suggest that HPV status detection is required to better plan and individualize patient treatment regimes.
Journal ArticleDOI
Factors predictive of survival in advanced laryngeal cancer.
Amy Y. Chen,Michael T. Halpern +1 more
TL;DR: Overall survival was decreased among men, black patients, and patients with Medicare or Medicaid or those who were uninsured (compared with those with private insurance), whereas both TL and chemo-RT improved survival over RT among patients with stage III cancer.
Journal ArticleDOI
Transoral laser microsurgery (TLM) +/- adjuvant therapy for advanced stage oropharyngeal cancer: outcomes and prognostic factors.
TL;DR: Document survival, prognostic variables, and functional outcomes of patients with AJCC stage III or IV oropharyngeal cancer, treated with transoral laser microsurgery (TLM) ± adjuvant therapy.
Journal ArticleDOI
Quality of Life for Patients Following Total Laryngectomy vs Chemoradiation for Laryngeal Preservation
Ehab Y. Hanna,Allen C. Sherman,David Cash,Dawn Camp Adams,Emre Vural,Chun-Yang Fan,James Y. Suen +6 more
TL;DR: Both chemoradiation and TL affect, albeit differently, the QOL of patients treated for advanced cancer of the larynx, and the overall QOL scores of both groups seem similar.
References
More filters
Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Journal Article
Evaluation of survival data and two new rank order statistics arising in its consideration.
Journal ArticleDOI
A Multiple Comparison Procedure for Comparing Several Treatments with a Control
TL;DR: In this article, a multiple comparison procedure for comparing several treatments with a control is presented, which is based on the Multiple Comparison Procedure for Comparing Several Treatments with a Control (MCPC).
Journal ArticleDOI
A Class of $K$-Sample Tests for Comparing the Cumulative Incidence of a Competing Risk
TL;DR: In this paper, a class of tests developed for comparing the cumulative incidence of a particular type of failure among different groups is presented. The tests are based on comparing weighted averages of the hazards of the subdistribution for the failure type of interest.
Journal ArticleDOI
Cancer statistics, 2003.
TL;DR: The American Cancer Society estimates the number of new cancer cases and deaths expected in the United States in the current year, and compiles the most recent data on cancer incidence, mortality, and survival by using incidence data from the National Cancer Institute (NCI) and mortality data from National Center for Health Statistics (NCHS).