Journal ArticleDOI
Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer
Arlene A. Forastiere,Helmuth Goepfert,Moshe H. Maor,Thomas F. Pajak,Randal S. Weber,William H. Morrison,Bonnie S. Glisson,Andy Trotti,John A. Ridge,C. Chao,Glen Peters,Ding Jen Lee,Andrea Leaf,John F. Ensley,Jay S. Cooper +14 more
TLDR
In patients with laryngeal cancer, radiotherapy with concurrent administration of cisplatin is superior to induction chemotherapy followed by radiotherapy or radiotherapy alone for larynGEal preservation and locoregional control.Abstract:
Background Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients with locally advanced laryngeal cancer. The value of adding chemotherapy to radiotherapy and the optimal timing of chemotherapy are unknown. Methods We randomly assigned patients with locally advanced cancer of the larynx to one of three treatments: induction cisplatin plus fluorouracil followed by radiotherapy, radiotherapy with concurrent administration of cisplatin, or radiotherapy alone. The primary end point was preservation of the larynx. Results A total of 547 patients were randomly assigned to one of the three study groups. The median follow-up period was 3.8 years. At two years, the proportion of patients who had an intact larynx after radiotherapy with concurrent cisplatin (88 percent) differed significantly from the proportions in the groups given induction chemotherapy followed by radiotherapy (75 percent, P=0.005) or radiotherapy alone (70 ...read more
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Journal ArticleDOI
The CD98 Heavy Chain Is a Marker and Regulator of Head and Neck Squamous Cell Carcinoma Radiosensitivity.
David Digomann,Ina Kurth,Ina Kurth,Anna Tyutyunnykova,Oleg Chen,Oleg Chen,Steffen Löck,Steffen Löck,Steffen Löck,Ielizaveta Gorodetska,Claudia Peitzsch,Ira-Ida Skvortsova,Giulia Negro,Bertram Aschenbrenner,Graeme Eisenhofer,Susan Richter,Stephan Heiden,Joseph Porrmann,Joseph Porrmann,Joseph Porrmann,Barbara Klink,Christian Schwager,Christian Schwager,Adam Dowle,Linda Hein,Leoni A. Kunz-Schughart,Amir Abdollahi,Amir Abdollahi,Fabian Lohaus,Mechthild Krause,Michael Baumann,Michael Baumann,Michael Baumann,Annett Linge,Anna Dubrovska,Anna Dubrovska +35 more
TL;DR: It is found that CD98hc-associated signaling mechanisms play a central role in the regulation of HNSCC radioresistance and may be a promising target for tumor radiosensitization.
Journal ArticleDOI
Dose-escalated intensity modulated radiotherapy is feasible and may improve locoregional control and laryngeal preservation in laryngo-hypopharyngeal cancers
Aisha Miah,Aisha Miah,Shreerang Bhide,Shreerang Bhide,M. Teresa Guerrero-Urbano,M. Teresa Guerrero-Urbano,Catharine H. Clark,Catharine H. Clark,A. Margaret Bidmead,A. Margaret Bidmead,Suzanne St. Rose,Yolanda Barbachano,Roger A'Hern,Mary Anne Lagmay Tanay,Jennifer Hickey,Robyn Nicol,Kate Newbold,Kevin J. Harrington,Kevin J. Harrington,Christopher M. Nutting,Christopher M. Nutting +20 more
TL;DR: In this study, DL2 delivered high rates of locoregional control, progression-free survival, and organ preservation and has been selected as the experimental arm in a Cancer Research UK Phase III study.
Journal ArticleDOI
Early prediction of response to chemoradiotherapy for head and neck cancer: reliability of restaging with combined positron emission tomography and computed tomography.
James Malone,Michael A. T. Gerberi,Syam Vasireddy,Larry F. Hughes,Krishna Rao,Bruce Shevlin,Matthew Kuhn,Dean Collette,Joel Tennenhouse,K. Thomas Robbins +9 more
TL;DR: Positive PET-CT findings accurately determine early disease response at the primary site and in the neck after chemoradiotherapy for advanced squamous cell carcinoma of the head and neck (SCCHN).
Journal ArticleDOI
New and emerging radiosensitizers and radioprotectors.
TL;DR: The most recent, predominantly early phase clinical trials combining systemic agents with radiation are reviewed and the search among schedules could be shortened by the use of surrogate endpoints such as presence of active drug metabolites in the tumor.
Journal ArticleDOI
A traditional Japanese medicine—Hangeshashinto (TJ-14)—alleviates chemoradiation-induced mucositis and improves rates of treatment completion
TL;DR: The present study indicates that TJ-14 is effective for ameliorating oral mucositis induced by (chemo)radiation in patients with head and neck cancers.
References
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Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Journal Article
Evaluation of survival data and two new rank order statistics arising in its consideration.
Journal ArticleDOI
A Multiple Comparison Procedure for Comparing Several Treatments with a Control
TL;DR: In this article, a multiple comparison procedure for comparing several treatments with a control is presented, which is based on the Multiple Comparison Procedure for Comparing Several Treatments with a Control (MCPC).
Journal ArticleDOI
A Class of $K$-Sample Tests for Comparing the Cumulative Incidence of a Competing Risk
TL;DR: In this paper, a class of tests developed for comparing the cumulative incidence of a particular type of failure among different groups is presented. The tests are based on comparing weighted averages of the hazards of the subdistribution for the failure type of interest.
Journal ArticleDOI
Cancer statistics, 2003.
TL;DR: The American Cancer Society estimates the number of new cancer cases and deaths expected in the United States in the current year, and compiles the most recent data on cancer incidence, mortality, and survival by using incidence data from the National Cancer Institute (NCI) and mortality data from National Center for Health Statistics (NCHS).