Journal ArticleDOI
Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer
Arlene A. Forastiere,Helmuth Goepfert,Moshe H. Maor,Thomas F. Pajak,Randal S. Weber,William H. Morrison,Bonnie S. Glisson,Andy Trotti,John A. Ridge,C. Chao,Glen Peters,Ding Jen Lee,Andrea Leaf,John F. Ensley,Jay S. Cooper +14 more
TLDR
In patients with laryngeal cancer, radiotherapy with concurrent administration of cisplatin is superior to induction chemotherapy followed by radiotherapy or radiotherapy alone for larynGEal preservation and locoregional control.Abstract:
Background Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients with locally advanced laryngeal cancer. The value of adding chemotherapy to radiotherapy and the optimal timing of chemotherapy are unknown. Methods We randomly assigned patients with locally advanced cancer of the larynx to one of three treatments: induction cisplatin plus fluorouracil followed by radiotherapy, radiotherapy with concurrent administration of cisplatin, or radiotherapy alone. The primary end point was preservation of the larynx. Results A total of 547 patients were randomly assigned to one of the three study groups. The median follow-up period was 3.8 years. At two years, the proportion of patients who had an intact larynx after radiotherapy with concurrent cisplatin (88 percent) differed significantly from the proportions in the groups given induction chemotherapy followed by radiotherapy (75 percent, P=0.005) or radiotherapy alone (70 ...read more
Citations
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Journal ArticleDOI
Differences in Survival With Surgery and Postoperative Radiotherapy Compared With Definitive Chemoradiotherapy for Oral Cavity Cancer: A National Cancer Database Analysis
Michael T. Spiotto,Gina D. Jefferson,Barry L. Wenig,Michael Markiewicz,Ralph R. Weichselbaum,Matthew Koshy +5 more
TL;DR: Compared with CRT, S+PORT was associated with improved survival for locally advanced OCSCCs, especially in T3 to T4a disease, and these data support the use of surgery as the initial treatment modality for operable O CSCCs.
Journal ArticleDOI
Supracricoid Partial Laryngectomy for Primary and Recurrent Laryngeal Cancer
TL;DR: This Retrospective case series demonstrates excellent local control for both primary and recurrent laryngeal cancers, with functional larynx preservation, and SCPL should be considered as a treatment alternative to non-surgical treatment or totallaryngectomy.
Journal ArticleDOI
Metabolic abnormalities associated with weight loss during chemoirradiation of head-and-neck cancer
Alexander Lin,Siavash Jabbari,Francis P. Worden,Carol R. Bradford,Douglas B. Chepeha,Theodoros N. Teknos,Jay J. Liao,Gurston Nyquist,Christina Tsien,Matthew J. Schipper,Susan G. Urba,Gregory T. Wolf,Avraham Eisbruch +12 more
TL;DR: Weight loss during cisplatin-containing chemo-RT was found to be associated with reduced kidney function and highlighted the importance of intensive supportive measures of nutrition and hydration beyond standard hydration during cis Platin administration.
Journal ArticleDOI
An NIR Discrete Metallacycle Constructed from Perylene Bisimide and Tetraphenylethylene Fluorophores for Imaging‐Guided Cancer Radio‐Chemotherapy
TL;DR: In this article , a theranostic metallacycle (M) is developed for imaging-guided cancer radio-chemotherapy using perylene bisimide fluorophore (PPy) and tetraphenylethylene-based di-Pt(II) organometallic precursor (TPE)-Pt) as building blocks.
Journal ArticleDOI
Primary staging of laryngeal and hypopharyngeal cancer: CT, MR imaging and dual-energy CT.
TL;DR: Radiologists need to understand the advantages and limitations of each imaging modality for staging of laryngeal and hypopharyngeAL cancer.
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