Journal ArticleDOI
Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer
Arlene A. Forastiere,Helmuth Goepfert,Moshe H. Maor,Thomas F. Pajak,Randal S. Weber,William H. Morrison,Bonnie S. Glisson,Andy Trotti,John A. Ridge,C. Chao,Glen Peters,Ding Jen Lee,Andrea Leaf,John F. Ensley,Jay S. Cooper +14 more
TLDR
In patients with laryngeal cancer, radiotherapy with concurrent administration of cisplatin is superior to induction chemotherapy followed by radiotherapy or radiotherapy alone for larynGEal preservation and locoregional control.Abstract:
Background Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients with locally advanced laryngeal cancer. The value of adding chemotherapy to radiotherapy and the optimal timing of chemotherapy are unknown. Methods We randomly assigned patients with locally advanced cancer of the larynx to one of three treatments: induction cisplatin plus fluorouracil followed by radiotherapy, radiotherapy with concurrent administration of cisplatin, or radiotherapy alone. The primary end point was preservation of the larynx. Results A total of 547 patients were randomly assigned to one of the three study groups. The median follow-up period was 3.8 years. At two years, the proportion of patients who had an intact larynx after radiotherapy with concurrent cisplatin (88 percent) differed significantly from the proportions in the groups given induction chemotherapy followed by radiotherapy (75 percent, P=0.005) or radiotherapy alone (70 ...read more
Citations
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Journal ArticleDOI
Organ preservation for advanced larynx cancer: A review of chemotherapy and radiation combination strategies.
TL;DR: Results from phase III studies suggest that patients with advanced T4 cancers have better outcomes with a primary surgical approach, while for patients with T2N+ and T3 tumors, definitive concurrent chemotherapy and radiation or induction chemotherapy followed by definitive radiation therapy are acceptable options.
Journal ArticleDOI
HPV Prevalence and Prognostic Value in a Prospective Cohort of 255 Patients with Locally Advanced HNSCC: A Single-Centre Experience.
E. Thibaudeau,Bernard Fortin,François Coutlée,Phuc Felix Nguyen-Tan,Xiaoduan Weng,Marie-Lise Audet,Olivier Abboud,Louis Guertin,Apostolos Christopoulos,Jean-Claude Tabet,Denis Soulières +10 more
TL;DR: It is confirmed that HPV status is associated with improved prognosis among H &N cancer patients receiving CRT and should be a stratification factor for clinical trials including H&N cases.
Journal ArticleDOI
Induction Chemotherapy for Locoregionally Advanced Head and Neck Cancer: Past, Present, Future?
TL;DR: How IC has evolved over the years is summarized, an update of recent developments is provided, and how IC may develop in the future is discussed.
Journal ArticleDOI
Changes in (18)F-fluorothymidine and (18)F-fluorodeoxyglucose positron emission tomography imaging in patients with head and neck cancer treated with chemoradiotherapy.
Hiroshi Hoshikawa,Terushige Mori,Takehito Kishino,Yuka Yamamoto,Ryuhei Inamoto,Kosuke Akiyama,Nozomu Mori,Yoshihiro Nishiyama +7 more
TL;DR: In this article, the authors compared change of 18F-fluorothymidine uptake with that of FDG in head and neck squamous cell cancer (HNSCC) patients during and after treatment and evaluated the utility for early monitoring of response to chemoradiotherapy.
Journal ArticleDOI
Patterns of extralaryngeal spread of laryngeal cancer: thyroid cartilage penetration occurs in a minority of patients with extralaryngeal spread of laryngeal squamous cell cancers.
Susie A. Chen,Susan Muller,Amy Y. Chen,Patricia A. Hudgins,Dong M. Shin,Fadlo R. Khuri,Nabil F. Saba,Jonathan J. Beitler +7 more
TL;DR: This study characterized and quantify the routes and frequency of ELS in patients with advanced laryngeal squamous cell carcinomas and confirmed that SCC spread into noncartilaginous structures may have less of a functional impact when compared with thyroid cartilage penetration.
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