Journal ArticleDOI
Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer
Arlene A. Forastiere,Helmuth Goepfert,Moshe H. Maor,Thomas F. Pajak,Randal S. Weber,William H. Morrison,Bonnie S. Glisson,Andy Trotti,John A. Ridge,C. Chao,Glen Peters,Ding Jen Lee,Andrea Leaf,John F. Ensley,Jay S. Cooper +14 more
TLDR
In patients with laryngeal cancer, radiotherapy with concurrent administration of cisplatin is superior to induction chemotherapy followed by radiotherapy or radiotherapy alone for larynGEal preservation and locoregional control.Abstract:
Background Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients with locally advanced laryngeal cancer. The value of adding chemotherapy to radiotherapy and the optimal timing of chemotherapy are unknown. Methods We randomly assigned patients with locally advanced cancer of the larynx to one of three treatments: induction cisplatin plus fluorouracil followed by radiotherapy, radiotherapy with concurrent administration of cisplatin, or radiotherapy alone. The primary end point was preservation of the larynx. Results A total of 547 patients were randomly assigned to one of the three study groups. The median follow-up period was 3.8 years. At two years, the proportion of patients who had an intact larynx after radiotherapy with concurrent cisplatin (88 percent) differed significantly from the proportions in the groups given induction chemotherapy followed by radiotherapy (75 percent, P=0.005) or radiotherapy alone (70 ...read more
Citations
More filters
Journal Article
Weekly cisplatin versus standard three-weekly cisplatin in concurrent chemoradiotherapy of head and neck cancer: the Baskent University experience
Fatih Kose,Ayberk Besen,Taner Sumbul,Ahmet Sezer,Cemile Karadeniz,Umut Disel,Ozden Altundag,Ozgur Ozyilkan +7 more
TL;DR: In patients with head and neck cancer, concurrent chemoradiotherapy with weekly cisplatin might be as effective as concurrentChemoradi therapy with bolus cis Platin.
Journal ArticleDOI
Mouse model of postsurgical primary tumor recurrence and regional lymph node metastasis progression in HPV-related head and neck cancer.
Maxime Mermod,Agnès Hiou-Feige,Esther Bovay,Vincent Roh,Jana Sponarova,Massimo Bongiovanni,Daniel W. Vermeer,John H. Lee,Tatiana V. Petrova,Jean-Paul Rivals,Yan Monnier,Genrich V. Tolstonog,Christian Simon +12 more
TL;DR: An immunocompetent mouse model of postsurgical local recurrence and regional and distant metastasis progression suitable for preclinical studies is developed.
Journal ArticleDOI
Complications That Affect Postlaryngectomy Voice Restoration: Primary Surgery vs Salvage Surgery
Heather M. Starmer,Stacey L. Ishman,Paul W. Flint,Nasir I. Bhatti,Jeremy D. Richmon,Wayne M. Koch,Kimberly Webster,Ralph P. Tufano,Christine G. Gourin +8 more
TL;DR: Voice prosthesis complications are more frequently encountered in those who require salvage laryngectomy and understanding the potential for such complications reinforces the need for close communication and follow-up with these patients by the speech language pathologist.
Journal ArticleDOI
Radiochemotherapy in Locally Advanced Squamous Cell Carcinomas of the Head and Neck
TL;DR: This overview reviews the most relevant published studies on the multidisciplinary management of SCCHN and discusses future strategies to reduce locoregional failures.
Journal ArticleDOI
Primary total laryngectomy and pharyngolaryngectomy in T4 pharyngolaryngeal cancers: Oncologic and functional results and prognostic factors.
M. Roux,Olivier Dassonville,Marc Ettaiche,Emmanuel Chamorey,Gilles Poissonnet,Alexandre Bozec +5 more
TL;DR: Primary TL/TPL remains the gold standard treatment for T4 larynx or hypopharynx cancer with extra-laryngeal extension and provides satisfactory oncologic and functional outcomes.
References
More filters
Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Journal Article
Evaluation of survival data and two new rank order statistics arising in its consideration.
Journal ArticleDOI
A Multiple Comparison Procedure for Comparing Several Treatments with a Control
TL;DR: In this article, a multiple comparison procedure for comparing several treatments with a control is presented, which is based on the Multiple Comparison Procedure for Comparing Several Treatments with a Control (MCPC).
Journal ArticleDOI
A Class of $K$-Sample Tests for Comparing the Cumulative Incidence of a Competing Risk
TL;DR: In this paper, a class of tests developed for comparing the cumulative incidence of a particular type of failure among different groups is presented. The tests are based on comparing weighted averages of the hazards of the subdistribution for the failure type of interest.
Journal ArticleDOI
Cancer statistics, 2003.
TL;DR: The American Cancer Society estimates the number of new cancer cases and deaths expected in the United States in the current year, and compiles the most recent data on cancer incidence, mortality, and survival by using incidence data from the National Cancer Institute (NCI) and mortality data from National Center for Health Statistics (NCHS).