Journal ArticleDOI
Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer
Arlene A. Forastiere,Helmuth Goepfert,Moshe H. Maor,Thomas F. Pajak,Randal S. Weber,William H. Morrison,Bonnie S. Glisson,Andy Trotti,John A. Ridge,C. Chao,Glen Peters,Ding Jen Lee,Andrea Leaf,John F. Ensley,Jay S. Cooper +14 more
TLDR
In patients with laryngeal cancer, radiotherapy with concurrent administration of cisplatin is superior to induction chemotherapy followed by radiotherapy or radiotherapy alone for larynGEal preservation and locoregional control.Abstract:
Background Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients with locally advanced laryngeal cancer. The value of adding chemotherapy to radiotherapy and the optimal timing of chemotherapy are unknown. Methods We randomly assigned patients with locally advanced cancer of the larynx to one of three treatments: induction cisplatin plus fluorouracil followed by radiotherapy, radiotherapy with concurrent administration of cisplatin, or radiotherapy alone. The primary end point was preservation of the larynx. Results A total of 547 patients were randomly assigned to one of the three study groups. The median follow-up period was 3.8 years. At two years, the proportion of patients who had an intact larynx after radiotherapy with concurrent cisplatin (88 percent) differed significantly from the proportions in the groups given induction chemotherapy followed by radiotherapy (75 percent, P=0.005) or radiotherapy alone (70 ...read more
Citations
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Journal ArticleDOI
Comparison of total laryngectomy with surgical (cricohyoidopexy) and nonsurgical organ-preservation modalities in advanced laryngeal squamous cell carcinomas: A multicenter retrospective analysis.
Francesco Bussu,Gaetano Paludetti,Giovanni Almadori,Armando De Virgilio,Jacopo Galli,Francesco Miccichè,Mario Tombolini,Davide Rizzo,Andrea Gallo,Veronica Giglia,Antonio Greco,Vincenzo Valentini,Marco de Vincentiis +12 more
TL;DR: Functional outcome and quality of life (QOL) have become relevant endpoints in the field of laryngeal oncology, leading to the emergence of organ‐preserving strategies.
Journal ArticleDOI
Best Practice in Systemic Therapy for Head and Neck Squamous Cell Carcinoma
TL;DR: The current standard of care in the curative and palliative setting is summarized, and best practice with regard to structural requirements, procedures, and monitoring outcome is described.
Journal ArticleDOI
Oncologic results of the surgical salvage of recurrent laryngeal squamous cell carcinoma in a multicentric retrospective series: Emerging role of supracricoid partial laryngectomy
Marco de Vincentiis,Armando De Virgilio,Francesco Bussu,Roberto Gallus,Andrea Gallo,G. Bastanza,Claudio Parrilla,Antonio Greco,Jacopo Galli,Rosaria Turchetta,Giovanni Almadori,Giulio Pagliuca,Vincenzo Valentini,Gaetano Paludetti +13 more
TL;DR: Several studies in the last decade evaluated conservative surgical procedures and, in particular, supracricoid operations as an alternative to total laryngectomy for the salvage of recurrences ofLaryngeal squamous cell carcinoma after a first attempt of organ preservation.
Journal ArticleDOI
Disorders of Swallowing: Palliative Care
TL;DR: This article defines palliative care for swallowing disorders as treatment for severe and chronic dysphagia or intractable aspiration when the recovery of normal swallowing is not anticipated and attempts to restore normal swallowing have been unsuccessful.
Journal ArticleDOI
Meta-analysis of Impaired Vocal Cord Mobility as a Prognostic Factor in T2 Glottic Carcinoma
Edward D. McCoul,Gady Har-El +1 more
TL;DR: It is indicated that impaired vocal cord mobility has a negative impact on local disease control and ultimate disease control in patients receiving primary radiotherapy for the treatment of T2 glottic carcinoma.
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