Journal ArticleDOI
Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer
Arlene A. Forastiere,Helmuth Goepfert,Moshe H. Maor,Thomas F. Pajak,Randal S. Weber,William H. Morrison,Bonnie S. Glisson,Andy Trotti,John A. Ridge,C. Chao,Glen Peters,Ding Jen Lee,Andrea Leaf,John F. Ensley,Jay S. Cooper +14 more
TLDR
In patients with laryngeal cancer, radiotherapy with concurrent administration of cisplatin is superior to induction chemotherapy followed by radiotherapy or radiotherapy alone for larynGEal preservation and locoregional control.Abstract:
Background Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients with locally advanced laryngeal cancer. The value of adding chemotherapy to radiotherapy and the optimal timing of chemotherapy are unknown. Methods We randomly assigned patients with locally advanced cancer of the larynx to one of three treatments: induction cisplatin plus fluorouracil followed by radiotherapy, radiotherapy with concurrent administration of cisplatin, or radiotherapy alone. The primary end point was preservation of the larynx. Results A total of 547 patients were randomly assigned to one of the three study groups. The median follow-up period was 3.8 years. At two years, the proportion of patients who had an intact larynx after radiotherapy with concurrent cisplatin (88 percent) differed significantly from the proportions in the groups given induction chemotherapy followed by radiotherapy (75 percent, P=0.005) or radiotherapy alone (70 ...read more
Citations
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Journal ArticleDOI
Prevention of wound complications following salvage laryngectomy using free vascularized tissue
Kevin Fung,Theodoros N. Teknos,Curtis VandenBerg,Teresa Lyden,Carol R. Bradford,Norman D. Hogikyan,Jennifer C. Kim,Mark E. Prince,Gregory T. Wolf,Douglas B. Chepeha +9 more
TL;DR: An approach using free tissue transfer is developed in an effort to improve tissue vascularity, reinforce the pharyngeal suture line, and minimize complications in this difficult patient population of salvage laryngectomy patients.
Journal ArticleDOI
Palifermin Reduces Severe Mucositis in Definitive Chemoradiotherapy of Locally Advanced Head and Neck Cancer: A Randomized, Placebo-Controlled Study
Quynh-Thu Le,Harold Kim,Charles J. Schneider,Györgyi Muraközy,Krzysztof Składowski,Sabine Reinisch,Yuhchyau Chen,Michael Hickey,May Mo,Mon Gy Chen,Dietmar Berger,Richard Lizambri,Michael Henke +12 more
TL;DR: Although palifermin reduced severe functional OM, its role in the management of locally advanced HNC during chemoradiotherapy remains to be elucidated.
Journal ArticleDOI
Human papillomavirus and oropharynx cancer: biology, detection and clinical implications.
TL;DR: Evidence for the role of human papillomavirus (HPV) in the etiology of oropharyngeal cancers, methods of viral detection, and the resulting clinical implications are reviewed.
Journal ArticleDOI
Humanized anti-interleukin-6 receptor antibody suppresses tumor angiogenesis and in vivo growth of human oral squamous cell carcinoma.
Satoru Shinriki,Hirofumi Jono,Kazutoshi Ota,Mitsuharu Ueda,Mareina Kudo,Tomoko Ota,Yuichi Oike,Motoyoshi Endo,Mutsuko Ibusuki,Akimitsu Hiraki,Hideki Nakayama,Yoshihiro Yoshitake,Masanori Shinohara,Yukio Ando +13 more
TL;DR: Therapeutic approaches targeting IL-6R by tocilizumab may be effective for OSCC treatment by at least inhibiting angiogenesis.
Journal ArticleDOI
Evaluating the role of prophylactic gastrostomy tube placement prior to definitive chemoradiotherapy for head and neck cancer.
Allen M. Chen,B. Li,Derick H Lau,D. Gregory Farwell,Quang Luu,Kerri Stuart,Kathleen Newman,James A. Purdy,Srinivasan Vijayakumar +8 more
TL;DR: Although prophylactic GT placement was effective at preventing acute weight loss and the need for intravenous hydration, it was also associated with significantly higher rates of late esophageal toxicity.
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