Journal ArticleDOI
Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer
Arlene A. Forastiere,Helmuth Goepfert,Moshe H. Maor,Thomas F. Pajak,Randal S. Weber,William H. Morrison,Bonnie S. Glisson,Andy Trotti,John A. Ridge,C. Chao,Glen Peters,Ding Jen Lee,Andrea Leaf,John F. Ensley,Jay S. Cooper +14 more
TLDR
In patients with laryngeal cancer, radiotherapy with concurrent administration of cisplatin is superior to induction chemotherapy followed by radiotherapy or radiotherapy alone for larynGEal preservation and locoregional control.Abstract:
Background Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients with locally advanced laryngeal cancer. The value of adding chemotherapy to radiotherapy and the optimal timing of chemotherapy are unknown. Methods We randomly assigned patients with locally advanced cancer of the larynx to one of three treatments: induction cisplatin plus fluorouracil followed by radiotherapy, radiotherapy with concurrent administration of cisplatin, or radiotherapy alone. The primary end point was preservation of the larynx. Results A total of 547 patients were randomly assigned to one of the three study groups. The median follow-up period was 3.8 years. At two years, the proportion of patients who had an intact larynx after radiotherapy with concurrent cisplatin (88 percent) differed significantly from the proportions in the groups given induction chemotherapy followed by radiotherapy (75 percent, P=0.005) or radiotherapy alone (70 ...read more
Citations
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miRNAs: micro-managers of anticancer combination therapies
Judy R. van Beijnum,Elisa Giovannetti,Dennis Poel,Patrycja Nowak-Sliwinska,Arjan W. Griffioen +4 more
TL;DR: The provenance and promise of miRNAs as targets as well as therapeutics to contribute to anti-angiogenesis-based (combination) treatment of cancer are reviewed.
Journal ArticleDOI
Reassessment of the role of induction chemotherapy for head and neck cancer
TL;DR: Data is summarized for the use of induction chemotherapy in the setting of locally advanced disease--both resectable and unresectable and which patients will likely benefit from this approach now and which questions are important in the design of future clinical trials.
Journal ArticleDOI
Head and Neck: Squamous cell carcinoma: an overview
A Rousseau,C Badoual +1 more
TL;DR: Review on Head and Neck: Squamous cell carcinoma: an overview, with data on clinics, and the genes involved.
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Emerging insights into head and neck cancer metastasis
TL;DR: The role of regional lymph nodes in containing advanced head and neck cancer, evidence for active as opposed to passive tumor cell metastasis, and clinical implications these concepts have on both treatment of head andneck cancer and future research are reviewed.
Journal ArticleDOI
Supraclavicular flap reconstruction following total laryngectomy.
TL;DR: Report on the successful use of the supraclavicular flap for reconstruction following total laryngectomy and highlight the utility and versatility of this flap.
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