Journal ArticleDOI
Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer
Arlene A. Forastiere,Helmuth Goepfert,Moshe H. Maor,Thomas F. Pajak,Randal S. Weber,William H. Morrison,Bonnie S. Glisson,Andy Trotti,John A. Ridge,C. Chao,Glen Peters,Ding Jen Lee,Andrea Leaf,John F. Ensley,Jay S. Cooper +14 more
TLDR
In patients with laryngeal cancer, radiotherapy with concurrent administration of cisplatin is superior to induction chemotherapy followed by radiotherapy or radiotherapy alone for larynGEal preservation and locoregional control.Abstract:
Background Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients with locally advanced laryngeal cancer. The value of adding chemotherapy to radiotherapy and the optimal timing of chemotherapy are unknown. Methods We randomly assigned patients with locally advanced cancer of the larynx to one of three treatments: induction cisplatin plus fluorouracil followed by radiotherapy, radiotherapy with concurrent administration of cisplatin, or radiotherapy alone. The primary end point was preservation of the larynx. Results A total of 547 patients were randomly assigned to one of the three study groups. The median follow-up period was 3.8 years. At two years, the proportion of patients who had an intact larynx after radiotherapy with concurrent cisplatin (88 percent) differed significantly from the proportions in the groups given induction chemotherapy followed by radiotherapy (75 percent, P=0.005) or radiotherapy alone (70 ...read more
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Journal ArticleDOI
Combined-modality treatment and organ preservation in bladder cancer. Do molecular markers predict outcome?
Christian Weiss,Franz Rödel,Ina Wolf,Thomas Papadopoulos,Dirk G. Engehausen,Karl M. Schrott,Rolf Sauer,Claus Rödel +7 more
TL;DR: In this article, the authors evaluated pre-treatment biopsies of 134 patients treated for bladder cancer by transurethral resection (TUR-BT) and radiochemotherapy (RCT) using immunohistochemistry.
Journal ArticleDOI
Predictive Value of Pretherapeutic Maximum Standardized Uptake Value (Suv max) In Laryngeal and Hypopharyngeal Cancer
Jonas Werner,Martin Hüllner,Niels J. Rupp,Alexander M. Huber,Martina A. Broglie,Gerhard F. Huber,Gerhard F. Huber,Grégoire B. Morand +7 more
TL;DR: Evaluating pretherapeutic metabolic tumor parameters from 18-fluorodeoxyglucose positron emission tomography (FDG-PET) imaging found that SUVmax of primary tumor could be used as a predictor of larynx preservation prior to primary chemoradiation in hypopharyngeal cancer patients.
Journal ArticleDOI
Weekly docetaxel in patients with platinum-refractory metastatic or recurrent squamous cell carcinoma of the head and neck
Byoung Chul Cho,Ki Chang Keum,Sang Joon Shin,Hye Jin Choi,Youngjoo Lee,Se Hun Kim,Eun Chang Choi,Joo Hang Kim +7 more
TL;DR: Weekly docetaxel regimen had good clinical activity with an acceptable toxicity in patients with platinum-refractory SCCHN.
Journal ArticleDOI
The multidimensional impact of total laryngectomy on women.
TL;DR: This paper examines the unique challenges women may face postlaryngectomy through the framework of the International Classification of Functioning, Disability, and Health (ICF) through the use of the ICF to provide an expanded perspective related to the interactions between body functioning, active participation in daily activities, and contextual factors that may act as facilitators or barriers to women's societal reintegration secondary to TL.
Journal ArticleDOI
Induction chemotherapy in locally advanced head and neck cancer: a new standard of care?
TL;DR: The newer TPF induction chemotherapy regimens also appear to be tolerated better than PF when accompanied by adequate supportive measures, and studies to enhance the efficacy of TPf induction chemotherapy by adding new targeted agents, such as the EGF-R inhibitors cetuximab and panitumumab, are underway.
References
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