Journal ArticleDOI
Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer
Arlene A. Forastiere,Helmuth Goepfert,Moshe H. Maor,Thomas F. Pajak,Randal S. Weber,William H. Morrison,Bonnie S. Glisson,Andy Trotti,John A. Ridge,C. Chao,Glen Peters,Ding Jen Lee,Andrea Leaf,John F. Ensley,Jay S. Cooper +14 more
TLDR
In patients with laryngeal cancer, radiotherapy with concurrent administration of cisplatin is superior to induction chemotherapy followed by radiotherapy or radiotherapy alone for larynGEal preservation and locoregional control.Abstract:
Background Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients with locally advanced laryngeal cancer. The value of adding chemotherapy to radiotherapy and the optimal timing of chemotherapy are unknown. Methods We randomly assigned patients with locally advanced cancer of the larynx to one of three treatments: induction cisplatin plus fluorouracil followed by radiotherapy, radiotherapy with concurrent administration of cisplatin, or radiotherapy alone. The primary end point was preservation of the larynx. Results A total of 547 patients were randomly assigned to one of the three study groups. The median follow-up period was 3.8 years. At two years, the proportion of patients who had an intact larynx after radiotherapy with concurrent cisplatin (88 percent) differed significantly from the proportions in the groups given induction chemotherapy followed by radiotherapy (75 percent, P=0.005) or radiotherapy alone (70 ...read more
Citations
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Journal ArticleDOI
Conventional radiotherapy with concurrent weekly Cisplatin in locally advanced head and neck cancers of squamous cell origin - a single institution experience.
TL;DR: In this article, weekly cisplatin at 35 mg/m2 when delivered concurrently with conventional radical RT (atleast 66y/33 fractions) in locally-advanced head and neck cancer is well tolerated with minimal hematologic and neprologic toxicity and can be routinely delivered on an out-patient basis.
Journal ArticleDOI
18F-FDG-PET/CT for the detection of disease in patients with head and neck cancer treated with radiotherapy.
Nils Helsen,Dessie Roothans,Bert Van Den Heuvel,Tim Van den Wyngaert,Danielle Van den Weyngaert,Laurens Carp,Sigrid Stroobants +6 more
TL;DR: FDG-PET/CT is able to detect residual disease after (chemo)radiotherapy, with an optimal time point for scanning between 11–12 weeks after therapy, however, a reevaluation is probably necessary 10–12 months after the FDG- PET/CT to detect late recurrences.
Journal ArticleDOI
Intra-Arterial Chemotherapy Less Intensive Than RADPLAT with Concurrent Radiotherapy for Resectable Advanced Head and Neck Squamous Cell Carcinoma: A Prospective Study
Tomokazu Yoshizaki,Naohiro Wakisaka,Shigeyuki Murono,Satoru Kondo,Yoshinori Shimizu,Tsuyoshi Takanaka,Junichiro Sanada,Noboru Terayama,Osamu Matsui,Mitsuru Furukawa +9 more
TL;DR: This intra-arterial chemotherapy protocol with a lower amount and frequency of cisplatin delivery than in RADPLAT is feasible and effective for advanced resectable head and neck cancer.
Journal ArticleDOI
Role of surgery in the management of head and neck cancer: a contemporary view of the data in the era of organ preservation.
K Hörmann,H Sadick +1 more
TL;DR: There is a definite need to apply more rigorous standards to the use of organ preservation strategies, and to re-evaluate the role of surgery in head and neck cancer treatment.
Journal ArticleDOI
Longitudinal Evaluation of Swallowing with Videofluoroscopy in Patients with Locally Advanced Head and Neck Cancer After Chemoradiation.
Ekaterini Xinou,Ioannis Chryssogonidis,Anna Kalogera-Fountzila,Dimitra Panagiotopoulou-Mpoukla,Athanasia Printza +4 more
TL;DR: Severe swallowing deficits and high aspiration rates are observed in HNC patients pre-CRT, which further deteriorate post- CRT, peak at 3 months, and despite slight improvement, persist over time, suggesting that these patients, regardless of the presence of subjective dysphagia, should undergo VFSS both before and 3 Months post-CRR, in order to facilitate implementation of early swallowing rehabilitation.
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