Journal ArticleDOI
Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer
Arlene A. Forastiere,Helmuth Goepfert,Moshe H. Maor,Thomas F. Pajak,Randal S. Weber,William H. Morrison,Bonnie S. Glisson,Andy Trotti,John A. Ridge,C. Chao,Glen Peters,Ding Jen Lee,Andrea Leaf,John F. Ensley,Jay S. Cooper +14 more
TLDR
In patients with laryngeal cancer, radiotherapy with concurrent administration of cisplatin is superior to induction chemotherapy followed by radiotherapy or radiotherapy alone for larynGEal preservation and locoregional control.Abstract:
Background Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients with locally advanced laryngeal cancer. The value of adding chemotherapy to radiotherapy and the optimal timing of chemotherapy are unknown. Methods We randomly assigned patients with locally advanced cancer of the larynx to one of three treatments: induction cisplatin plus fluorouracil followed by radiotherapy, radiotherapy with concurrent administration of cisplatin, or radiotherapy alone. The primary end point was preservation of the larynx. Results A total of 547 patients were randomly assigned to one of the three study groups. The median follow-up period was 3.8 years. At two years, the proportion of patients who had an intact larynx after radiotherapy with concurrent cisplatin (88 percent) differed significantly from the proportions in the groups given induction chemotherapy followed by radiotherapy (75 percent, P=0.005) or radiotherapy alone (70 ...read more
Citations
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Journal ArticleDOI
Multifunctional Chitosan-Capped Gold Nanoparticles for enhanced cancer chemo-radiotherapy: An invitro study.
TL;DR: Interestingly, the developed multifunctional CS-GNPs-DOX provided a synergistic regimen for cancer treatment that effectively delivered DOX to tumor cells and enhanced the radiosensitization activity, thus minimizing conventional radio-therapeutic required doses.
Journal ArticleDOI
Practical considerations in reducing swallowing dysfunction following concurrent chemoradiotherapy with intensity-modulated radiotherapy for head and neck cancer
TL;DR: A critical review of the current literature assesses the feasibility of IMRT to maintain swallowing function and appraises the various dosimetric parameters that have been proposed to help minimize long‐term dysphagia.
Journal ArticleDOI
Multicenter phase II study of an opioid-based pain control program for head and neck cancer patients receiving chemoradiotherapy
Sadamoto Zenda,Kazuto Matsuura,Hiroyuki Tachibana,Akihiro Homma,Tadaaki Kirita,Nobuya Monden,Shigemichi Iwae,Yojiro Ota,Tetsuo Akimoto,Hiroshi Otsuru,Makoto Tahara,Kengo Kato,Masao Asai +12 more
TL;DR: Use of a systematic pain control program may improve compliance with CRT in head and neck cancer patients who receive definitive or postoperative chemoradiotherapy.
Journal ArticleDOI
Functional organ preservation with definitive chemoradiotherapy for T4 laryngeal squamous cell carcinoma
B.R. Knab,Joseph K. Salama,Abhishek A. Solanki,Kerstin M. Stenson,Ezra E.W. Cohen,M. E. Witt,Daniel J. Haraf,Everett E. Vokes +7 more
TL;DR: Promising control and functional outcomes are achieved with TFHX for T4 laryngeal patients, including those with LVT4 disease, treated with chemoradiotherapy.
Journal ArticleDOI
Twenty-five years experience with laser surgery for head and neck tumors : report of an international symposium, Göttingen, Germany, 2005.
TL;DR: An international symposium on the surgical principles of laser resection, the oncological and functional results in comparison with traditional therapy, the difficulties and limits of laser surgery in distinct anatomical regions and on the role of radiotherapy was held in Göttingen.
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