Journal ArticleDOI
Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer
Arlene A. Forastiere,Helmuth Goepfert,Moshe H. Maor,Thomas F. Pajak,Randal S. Weber,William H. Morrison,Bonnie S. Glisson,Andy Trotti,John A. Ridge,C. Chao,Glen Peters,Ding Jen Lee,Andrea Leaf,John F. Ensley,Jay S. Cooper +14 more
TLDR
In patients with laryngeal cancer, radiotherapy with concurrent administration of cisplatin is superior to induction chemotherapy followed by radiotherapy or radiotherapy alone for larynGEal preservation and locoregional control.Abstract:
Background Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients with locally advanced laryngeal cancer. The value of adding chemotherapy to radiotherapy and the optimal timing of chemotherapy are unknown. Methods We randomly assigned patients with locally advanced cancer of the larynx to one of three treatments: induction cisplatin plus fluorouracil followed by radiotherapy, radiotherapy with concurrent administration of cisplatin, or radiotherapy alone. The primary end point was preservation of the larynx. Results A total of 547 patients were randomly assigned to one of the three study groups. The median follow-up period was 3.8 years. At two years, the proportion of patients who had an intact larynx after radiotherapy with concurrent cisplatin (88 percent) differed significantly from the proportions in the groups given induction chemotherapy followed by radiotherapy (75 percent, P=0.005) or radiotherapy alone (70 ...read more
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Journal ArticleDOI
Head and neck cancer: changing epidemiology, diagnosis, and treatment.
TL;DR: This review focuses on the goal of organ preservation and postoperative treatment of high-risk patients with the concurrent use of chemotherapy and radiation therapy with the role of inhibitors of the epidermal growth factor receptor in locally advanced and recurrent/metastatic squamous cell cancer of the head and neck.
Journal ArticleDOI
Current concepts in management of oral cancer – Surgery
Jatin P. Shah,Ziv Gil +1 more
TL;DR: The role of the surgeon is essential throughout the life history of a patient with a malignant neoplasm in the head and neck area, from initial diagnosis through definitive treatment, post-treatment surveillance, management of complications, rehabilitation of the sequelae of treatment, and finally for palliation of symptoms.
Journal ArticleDOI
Impact of Late Treatment-Related Toxicity on Quality of Life Among Patients With Head and Neck Cancer Treated With Radiotherapy
Johannes A. Langendijk,Patricia Doornaert,Irma M. Verdonck-de Leeuw,Charles R. Leemans,Neil K. Aaronson,Ben J. Slotman +5 more
TL;DR: Late radiation-induced toxicity, particularly RTOG (swallowing) and RTOG(xerostomia), has a significant impact on the more general dimensions of HRQoL, and the development of new radiation- induced delivery techniques should not only focus on reduction of the dose to the salivary glands, but also on anatomic structures that are involved in swallowing.
Journal ArticleDOI
Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial.
Robert I. Haddad,Robert I. Haddad,Anne O'Neill,Guilherme Rabinowits,Roy B. Tishler,Fadlo R. Khuri,Douglas Adkins,Joseph I. Clark,Nicholas J. Sarlis,Jochen H. Lorch,Jonathan J. Beitler,Sewanti Limaye,Sarah Riley,Marshall R. Posner +13 more
TL;DR: Although survival results were good in both groups there was no difference noted between those patients treated with induction chemotherapy followed by chemoradiotherapy and those who received chemoradotherapy alone, and the addition of induction chemotherapy remains an appropriate approach for advanced disease with high risk for local or distant failure.
Journal ArticleDOI
Randomized Trial of Radiotherapy Versus Concurrent Chemoradiotherapy Followed by Adjuvant Chemotherapy in Patients With American Joint Committee on Cancer/International Union Against Cancer Stage III and IV Nasopharyngeal Cancer of the Endemic Variety
Joseph Wee,Eng Huat Tan,Bee Choo Tai,Hwee Bee Wong,Swan Swan Leong,Terence Tan,Eu Tiong Chua,Edward Yang,Khai Mun Lee,Kam Weng Fong,Hoon Seng Khoo Tan,Lee Ks,Susan Loong,Vijay K Sethi,Eu Jin Chua,David Machin +15 more
TL;DR: It is confirmed that chemotherapy improves the distant metastasis control rate in NPC and its applicability to endemic NPC is demonstrated.
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