Journal ArticleDOI
Prenatal maternal stress, fetal programming, and mechanisms underlying later psychopathology-A global perspective
TLDR
It is now time to understand more about prenatal stress and psychopathology, and the role of both social and biological differences, in the rest of the world.Abstract:
There is clear evidence that the mother's stress, anxiety, or depression during pregnancy can alter the development of her fetus and her child, with an increased risk for later psychopathology. We are starting to understand some of the underlying mechanisms including the role of the placenta, gene-environment interactions, epigenetics, and specific systems including the hypothalamic-pituitary-adrenal axis and cytokines. In this review we also consider how these effects may be different, and potentially exacerbated, in different parts of the world. There can be many reasons for elevated prenatal stress, as in communities at war. There may be raised pregnancy-specific anxiety with high levels of maternal and infant death. There can be raised interpersonal violence (in Afghanistan 90.2% of women thought that "wife beating" was justified compared with 2.0% in Argentina). There may be interactions with nutritional deficiencies or with extremes of temperature. Prenatal stress alters the microbiome, and this can differ in different countries. Genetic differences in different ethnic groups may make some more vulnerable or more resilient to the effects of prenatal stress on child neurodevelopment. Most research on these questions has been in predominantly Caucasian samples from high-income countries. It is now time to understand more about prenatal stress and psychopathology, and the role of both social and biological differences, in the rest of the world.read more
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Child and adolescent mental health worldwide: evidence for action
TL;DR: In this article, the authors review the evidence and the gaps in the published work in terms of prevalence, risk and protective factors, and interventions to prevent and treat childhood and adolescent mental health problems.
Journal ArticleDOI
Birth of a Father: Fathering in the First 1,000 Days
Marian J. Bakermans-Kranenburg,Anna M. Lotz,Kim Alyousefi-van Dijk,Marinus H. van IJzendoorn +3 more
TL;DR: A context‐dependent biobehavioral model of emergent fatherhood is proposed in which sociocultural, behavioral, hormonal, and neural factors develop and interact during the first 1,000 days of fatherhood.
Posted ContentDOI
Impact of the COVID-19 Pandemic on Early Child Cognitive Development: Initial Findings in a Longitudinal Observational Study of Child Health
TL;DR: In this paper, the authors examined general childhood cognitive scores in 2020 and 2021 vs. the preceding decade, 2011-2019 and found that children born during the pandemic have significantly reduced verbal, motor, and overall cognitive performance compared to children born pre-pandemic.
Maternal Licorice Consumption During Pregnancy and Pubertal, Cognitive, and Psychiatric Outcomes in Children
Katri Räikkönen,Silja Martikainen,Anu-Katriina Pesonen,Jari Lahti,Kati Heinonen,Riikka Pyhälä,Marius Lahti,Soile Tuovinen,Karoliina Wehkalampi,Sara Sammallahti,Liisa Kuula,Sture Andersson,Johan G. Eriksson,Alfredo Ortega-Alonso,Rebecca M. Reynolds,Timo E. Strandberg,Jonathan R. Seckl,Eero Kajantie +17 more
TL;DR: Girls and boys exposed to high maternal glycyrrhizin consumption scored 7 (95% CI: 3.1, 11.2) points lower on tests of intelligence quotient, had poorer memory, and had 3.3-fold higher odds of attention deficit/hyperactivity disorder problems compared with children whose mothers consumed little to no glycyRrhiz in.
Journal ArticleDOI
Persistently High Levels of Maternal Antenatal Inflammation Are Associated With and Mediate the Effect of Prenatal Environmental Adversities on Neurodevelopmental Delay in the Offspring.
Polina Girchenko,Marius Lahti-Pulkkinen,Kati Heinonen,Rebecca M. Reynolds,Hannele Laivuori,Jari Lipsanen,Pia M. Villa,Esa Hämäläinen,Eero Kajantie,Jari Lahti,Katri Räikkönen +10 more
TL;DR: In this article, maternal antenatal inflammation was associated with the number of neurodevelopmental delay areas in children and whether it mediated the association between exposure to any prenatal environmental adversity and child neuro developmental delay.
References
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TL;DR: Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.
Journal ArticleDOI
Child and adolescent mental health worldwide: evidence for action
Christian Kieling,Helen Baker-Henningham,Myron L. Belfer,Gabriella Conti,Ilgi Ozturk Ertem,Olayinka Omigbodun,Luis Augusto Rohde,Shoba Srinath,Nurper Ulkuer,Atif Rahman +9 more
TL;DR: The evidence and the gaps in the published work in terms of prevalence, risk and protective factors, and interventions to prevent and treat childhood and adolescent mental health problems are reviewed.
Journal ArticleDOI
Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses
Tim F. Oberlander,Joanne Weinberg,Michael Papsdorf,Ruth E. Grunau,Shaila Misri,Angela M. Devlin +5 more
TL;DR: Prenatal exposure to increased third trimester maternal depressed/anxious mood was associated with increased methylation of NR3C1 at a predicted NGFI-A binding site, which may offer a potential epigenetic process that links antenatal maternal mood and altered HPA stress reactivity during infancy.
Journal ArticleDOI
Prevalence and determinants of common perinatal mental disorders in women in low- and lower-middle-income countries: a systematic review
Jane Fisher,Meena Cabral de Mello,Vikram Patel,Atif Rahman,Thach Duc Tran,Sara Holton,Wendy Holmes +6 more
TL;DR: CPMDs are more prevalent in low- and lower-middle-income countries, particularly among poorer women with gender-based risks or a psychiatric history.
Journal ArticleDOI
The course of anxiety and depression through pregnancy and the postpartum in a community sample.
TL;DR: It is confirmed that antenatal anxiety occurs frequently, overlaps with depression and increases the likelihood of postnatal depression.
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