Elucidation of extracellular matrix mechanics from muscle fibers and fiber bundles.
TLDR
A new method to quantify viscoelastic ECM modulus is presented by combining tests of single muscle fibers and fiber bundles, which demonstrate that ECM is a highly nonlinearly elastic material, while muscle fibers are linearly elastic.About:
This article is published in Journal of Biomechanics.The article was published on 2011-02-24 and is currently open access. It has received 156 citations till now. The article focuses on the topics: Skeletal muscle.read more
Citations
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Journal ArticleDOI
Predicting muscle tissue response from calibrated component models and histology-based finite element models.
Ramachandra Kuravi,Kay Leichsenring,Robin Trostorf,Enrique Morales-Orcajo,Markus Böl,Alexander E. Ehret +5 more
TL;DR: In this paper, an inverse finite element procedure is proposed to calibrate a constitutive model of the extracellular matrix, and supplementary biaxial tensile tests on fresh and decellularised tissues are performed for model validation.
Journal ArticleDOI
Molecular Mechanisms of Muscle Tone Impairment under Conditions of Real and Simulated Space Flight
Шенкман Борис Стивович (Ru),Цатурян Андрей Кимович,Вихлянцев Иван Милентьевич,Козловская Инесса Бенедиктовна,Григорьев Анатолий Иванович (Ru) +4 more
TL;DR: In this article, the main facts on intrinsic muscle stiffness under conditions of gravitational unloading are considered in a review, and the results and hypotheses regarding reduced probability of cross-bridge formation in an atrophying muscle due to increased interfilament spacing are described.
Determinants of active and passive tension in skeletal muscle
TL;DR: An approach combining mechanical testing, biochemical assays, and computation modeling was implemented to show that both active and passive performance characteristics can be accurately predicted using a combination of muscle architecture and protein composition under both healthy and pathologic conditions.
Journal ArticleDOI
Computational Models Provide Insight into In Vivo Studies and Reveal the Complex Role of Fibrosis in mdx Muscle Regeneration
Kelley M. Virgilio,Brian K Jones,Emily Miller,Elnaz Ghajar-Rahimi,Kyle S. Martin,Shayn M. Peirce,Silvia S. Blemker +6 more
TL;DR: The results suggest that increases in ECM area fraction alone are not sufficient to reduce the regenerative capacity of mdx muscle, and that fibrosis is a complex pathological condition requiring further understanding.
Book ChapterDOI
Muscle Biology of Contractures in Children with Cerebral Palsy
TL;DR: Overall these findings suggest that impaired muscle growth and contractures in children with cerebral palsy are related to a reduced muscle stem cell number.
References
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Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
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Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture
Penney M. Gilbert,Karen Havenstrite,Klas E. G. Magnusson,Klas E. G. Magnusson,Alessandra Sacco,Nora Leonardi,Nora Leonardi,Peggy E. Kraft,N. K. Nguyen,Sebastian Thrun,Matthias P. Lutolf,Helen M. Blau +11 more
TL;DR: Using a bioengineered substrate to recapitulate key biophysical and biochemical niche features in conjunction with a highly automated single-cell tracking algorithm, it is shown that substrate elasticity is a potent regulator of MuSC fate in culture.
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Matrix elasticity directs stem cell lineage — Soluble factors that limit osteogenesis
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Cell surface receptors for extracellular matrix molecules
Clayton A. Buck,Alan F. Horwitz +1 more
TL;DR: Avian integrin shows little specificity and appears to behave as a multifunctional, promiscuous receptor for extracellular matrix molecules, and post-translational modifications provide yet another mechanism for regulating integrin-ligand binding.
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Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments.
Henk Granzier,Thomas C. Irving +1 more
TL;DR: The passive tension-sarcomere length relation of rat cardiac muscle was investigated by studying passive (or not activated) single myocytes and trabeculae and the contribution of collagen, titin, microtubules, and intermediate filaments to tension and stiffness was investigated.