Elucidation of extracellular matrix mechanics from muscle fibers and fiber bundles.
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TLDR
A new method to quantify viscoelastic ECM modulus is presented by combining tests of single muscle fibers and fiber bundles, which demonstrate that ECM is a highly nonlinearly elastic material, while muscle fibers are linearly elastic.About:
This article is published in Journal of Biomechanics.The article was published on 2011-02-24 and is currently open access. It has received 156 citations till now. The article focuses on the topics: Skeletal muscle.read more
Citations
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Extracellular matrix remodelling induced by alternating electrical and mechanical stimulations increases the contraction of engineered skeletal muscle tissues.
TL;DR: Both the experimental results and the mechanistic model suggest that the combined stimulation through coordination reorients the ECM fibres in such a way that the parallel ECM stiffness is reduced, while the serial ECm stiffness is increased.
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Laminin and Matrix metalloproteinase 11 regulate Fibronectin levels in the zebrafish myotendinous junction.
TL;DR: The results identify a mechanism for Fn downregulation at the MTJ, highlight crosstalk between laminin and Fn, and identify a new in vivo function for Mmp11, demonstrating a novel signaling pathway mediating Fn down regulation.
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A continuum model for tension-compression asymmetry in skeletal muscle
TL;DR: This work presents a model which is able to accurately capture five experimental tests in chicken pectoralis muscle, including the observed tension-compression asymmetry, however, aspects of the anisotropy of the tissue are not captured by the model.
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The Energy of Muscle Contraction. I. Tissue Force and Deformation During Fixed-End Contractions.
James M. Wakeling,Stephanie A. Ross,David S. Ryan,Bart Bolsterlee,Ryan N. Konno,Sebastián Domínguez,Nilima Nigam +6 more
TL;DR: This paper tracks the redistribution of strain-energy potentials through the muscle tissue during fixed-end contractions, and shows how fibre shortening, pennation angle, transverse bulging and anisotropy in the stress and strain of the muscles tissue are all related to the interaction between the material properties of the muscle and the action of the contractile elements.
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Fibre and extracellular matrix contributions to passive forces in human skeletal muscles: An experimental based constitutive law for numerical modelling of the passive element in the classical Hill-type three element model.
Lorenzo Marcucci,Michela Bondì,Giulia Randazzo,Carlo Reggiani,Arturo N. Natali,Piero G. Pavan +5 more
TL;DR: The results showed that modulus and tensile load bearing capability of ECM are higher than those of fibres and defined their quantitative characterization that can be used in macroscopic models to study their role in the transmission of forces in physiological and pathophysiological conditions.
References
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Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
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Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture
Penney M. Gilbert,Karen Havenstrite,Klas E. G. Magnusson,Klas E. G. Magnusson,Alessandra Sacco,Nora Leonardi,Nora Leonardi,Peggy E. Kraft,N. K. Nguyen,Sebastian Thrun,Matthias P. Lutolf,Helen M. Blau +11 more
TL;DR: Using a bioengineered substrate to recapitulate key biophysical and biochemical niche features in conjunction with a highly automated single-cell tracking algorithm, it is shown that substrate elasticity is a potent regulator of MuSC fate in culture.
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Matrix elasticity directs stem cell lineage — Soluble factors that limit osteogenesis
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Cell surface receptors for extracellular matrix molecules
Clayton A. Buck,Alan F. Horwitz +1 more
TL;DR: Avian integrin shows little specificity and appears to behave as a multifunctional, promiscuous receptor for extracellular matrix molecules, and post-translational modifications provide yet another mechanism for regulating integrin-ligand binding.
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Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments.
Henk Granzier,Thomas C. Irving +1 more
TL;DR: The passive tension-sarcomere length relation of rat cardiac muscle was investigated by studying passive (or not activated) single myocytes and trabeculae and the contribution of collagen, titin, microtubules, and intermediate filaments to tension and stiffness was investigated.