Elucidation of extracellular matrix mechanics from muscle fibers and fiber bundles.
TLDR
A new method to quantify viscoelastic ECM modulus is presented by combining tests of single muscle fibers and fiber bundles, which demonstrate that ECM is a highly nonlinearly elastic material, while muscle fibers are linearly elastic.About:
This article is published in Journal of Biomechanics.The article was published on 2011-02-24 and is currently open access. It has received 156 citations till now. The article focuses on the topics: Skeletal muscle.read more
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A microstructurally-based, multi-scale, continuum-mechanical model for the passive behaviour of skeletal muscle tissue.
TL;DR: This work presents a novel microstructurally-based, multi-scale model describing the passive behaviour of skeletal muscle tissue, which reveals that muscle tissue exhibits a tensile stiffness that is larger transverse to the muscle fibre than in muscle fibre direction.
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Non-linear Scaling of Passive Mechanical Properties in Fibers, Bundles, Fascicles and Whole Rabbit Muscles.
TL;DR: Insight is provided into the structural basis of passive tension and the extracellular matrix (ECM) is the dominant contributor to whole muscle and fascicle passive tension, and caution should be used when inferring whole muscle properties from reduced muscle size preparations such as muscle biopsies.
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Surface Micro‐ and Nanoengineering: Applications of Layer‐by‐Layer Technology as a Versatile Tool to Control Cellular Behavior
TL;DR: An overview of bottom-up and top-down approaches reported to produce materials capable of mimicking the ECM topography and being applied for biomedical purposes is provided and the increasing motivation of using the layer-by-layer (LbL) technique to reproduce these topographical cues is highlighted.
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Skeletal muscle tensile strain dependence: Hyperviscoelastic nonlinearity
Benjamin B. Wheatley,Duane A. Morrow,Gregory M. Odegard,Kenton R. Kaufman,Tammy L. Haut Donahue +4 more
TL;DR: Material properties of skeletal muscle are strain-dependent at the tissue level and can be included in computational models of skeletal skeletal muscle performance with a fully nonlinear hyperviscoelastic model.
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NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice
James A. Loehr,Shang Wang,Tanya R. Cully,Rituraj Pal,Irina V. Larina,Kirill V. Larin,Kirill V. Larin,Kirill V. Larin,George G. Rodney +8 more
TL;DR: Investigating the role of Nox2 ROS in diaphragm tissue microtubule organization, stiffness and muscle/respiratory function established Nox 2 as a potential therapeutic target in Duchenne muscular dystrophy.
References
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Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
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Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture
Penney M. Gilbert,Karen Havenstrite,Klas E. G. Magnusson,Klas E. G. Magnusson,Alessandra Sacco,Nora Leonardi,Nora Leonardi,Peggy E. Kraft,N. K. Nguyen,Sebastian Thrun,Matthias P. Lutolf,Helen M. Blau +11 more
TL;DR: Using a bioengineered substrate to recapitulate key biophysical and biochemical niche features in conjunction with a highly automated single-cell tracking algorithm, it is shown that substrate elasticity is a potent regulator of MuSC fate in culture.
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Matrix elasticity directs stem cell lineage — Soluble factors that limit osteogenesis
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Cell surface receptors for extracellular matrix molecules
Clayton A. Buck,Alan F. Horwitz +1 more
TL;DR: Avian integrin shows little specificity and appears to behave as a multifunctional, promiscuous receptor for extracellular matrix molecules, and post-translational modifications provide yet another mechanism for regulating integrin-ligand binding.
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Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments.
Henk Granzier,Thomas C. Irving +1 more
TL;DR: The passive tension-sarcomere length relation of rat cardiac muscle was investigated by studying passive (or not activated) single myocytes and trabeculae and the contribution of collagen, titin, microtubules, and intermediate filaments to tension and stiffness was investigated.