Functions of RANKL/RANK/OPG in bone modeling and remodeling.
Brendan F. Boyce,Lianping Xing +1 more
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TLDR
The current understanding of the role of the RANKL/RANK/OPG system in bone modeling and remodeling is reviewed to show that the relative concentration of RankL and OPG in bone is a major determinant of bone mass and strength.About:
This article is published in Archives of Biochemistry and Biophysics.The article was published on 2008-05-15 and is currently open access. It has received 1414 citations till now. The article focuses on the topics: Osteoclast & Bone remodeling.read more
Citations
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Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells
Rinaldo Florencio-Silva,Gisela Rodrigues da Silva Sasso,Estela Sasso-Cerri,Manuel Simões,Paulo Sérgio Cerri +4 more
TL;DR: Current data about the structure and functions of bone cells and the factors that influence bone remodeling are discussed, indicating the dynamic nature of bone tissue.
Journal ArticleDOI
Osteocyte Wnt/β-Catenin Signaling Is Required for Normal Bone Homeostasis
Ina Kramer,Christine Halleux,Hansjoerg Keller,Marco Pegurri,Jonathan H. Gooi,Patricia Brander Weber,Jian Q. Feng,Lynda F. Bonewald,Michaela Kneissel +8 more
TL;DR: Results reveal a crucial novel function for osteocyte β-catenin signaling in controlling bone homeostasis in osteocyte-specific β- catenin mutants.
Journal ArticleDOI
Osteoblast–osteoclast interactions
TL;DR: The current knowledge on osteoblast–osteoclast communication is summarized and drugs could be developed by enhancing or restricting some of these interactions.
Journal ArticleDOI
Nanosized hydroxyapatite and other calcium phosphates: chemistry of formation and application as drug and gene delivery agents.
Vuk Uskoković,Dragan Uskoković +1 more
TL;DR: Calcium phosphate nanoparticles as carriers of therapeutic agents that would enable a controlled drug release to treat a given bone infection and at the same be resorbed in the body so as to regenerate hard tissue lost to disease are emphasized as one of the potentially attractive smart materials for the modern medicine.
Journal ArticleDOI
The Charcot Foot in Diabetes
Lee C. Rogers,Robert G. Frykberg,David G. Armstrong,Andrew J.M. Boulton,Michael Edmonds,Georges Ha Van,Agnes Hartemann,Frances L. Game,William Jeffcoate,Alexandra Jirkovská,Edward B. Jude,Stephan Morbach,William B. Morrison,Michael S. Pinzur,Dario Pitocco,Lee J. Sanders,Dane K. Wukich,Luigi Uccioli +17 more
TL;DR: An international task force of experts was convened by the American Diabetes Association and the American Podiatric Medical Association in January 2011 to summarize available evidence on the pathophysiology, natural history, presentations, and treatment recommendations for this entity.
References
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Osteoclast differentiation and activation
TL;DR: Discovery of the RANK signalling pathway in the osteoclast has provided insight into the mechanisms of osteoporosis and activation of bone resorption, and how hormonal signals impact bone structure and mass.
Journal ArticleDOI
Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation
David L. Lacey,Emma Timms,Hong-Lin Tan,Michael J. Kelley,Colin R. Dunstan,Tim Burgess,Robin Elliott,Anne Colombero,Gary Elliott,S. Scully,Hailing Hsu,John K. Sullivan,Nessa Hawkins,E. Davy,C. Capparelli,Alana Eli,Yi-xin Qian,Steve Kaufman,Ildiko Sarosi,Victoria Shalhoub,Giorgio Senaldi,Jane Guo,John M. Delaney,William J. Boyle +23 more
TL;DR: The effects of OPGL are blocked in vitro and in vivo by OPG, suggesting that OPGl and OPG are key extracellular regulators of osteoclast development.
Journal ArticleDOI
Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density
William S. Simonet,David L. Lacey,Colin R. Dunstan,Michael J. Kelley,Ming-Shi Chang,R Lüthy,Hung Q. Nguyen,S Wooden,L Bennett,Tom Boone,Grant Shimamoto,Margaret L. DeRose,Robin Elliott,Anne Colombero,Hong-Lin Tan,Geraldine Trail,John K. Sullivan,E. Davy,N. Bucay,L Renshaw-Gegg,T.M Hughes,Dave Hill,W Pattison,Patricia Shehan Campbell,S Sander,Gwyneth Van,John E. Tarpley,P Derby,Richard Lee,William J. Boyle +29 more
TL;DR: Data show that OPG can act as a soluble factor in the regulation of bone mass and imply a utility for OPG in the treatment of osteoporosis associated with increased osteoclast activity.
Journal ArticleDOI
Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation
TL;DR: Cloned cDNA encoding Osf2/Cbfa1 is identified as an osteoblast-specific transcription factor and as a regulator of osteoblasts differentiation.
Journal ArticleDOI
Targeted Disruption of Cbfa1 Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts
Toshihisa Komori,Hideshi Yagi,Shintaro Nomura,Akira Yamaguchi,Koichi Sasaki,Kenji Deguchi,Y Shimizu,Roderick T. Bronson,Y.-H Gao,Masahiko Inada,Makoto Sato,R Okamoto,Yukihiko Kitamura,Shusaku Yoshiki,Tadamitsu Kishimoto +14 more
TL;DR: The data suggest that both intramembranous and endochondral ossification were completely blocked, owing to the maturational arrest of osteoblasts in the mutant mice, and demonstrate that Cbfa1 plays an essential role in osteogenesis.
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Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation
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