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Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer
Laufey T. Amundadottir,Peter Kraft,Rachael Z. Stolzenberg-Solomon,Charles S. Fuchs,Gloria M. Petersen,Alan A. Arslan,H. Bas Bueno-de-Mesquita,Myron D. Gross,Kathy J. Helzlsouer,Eric J. Jacobs,Andrea Z. LaCroix,Wei Zheng,Demetrius Albanes,William R. Bamlet,Christine D. Berg,Franco Berrino,Sheila Bingham,Julie E. Buring,Paige M. Bracci,Federico Canzian,Françoise Clavel-Chapelon,Sandra Clipp,Michelle Cotterchio,Mariza de Andrade,Eric J. Duell,John W. Fox,Steven Gallinger,J. Michael Gaziano,J. Michael Gaziano,Edward Giovannucci,Michael Goggins,Carlos A. González,Göran Hallmans,Susan E. Hankinson,Manal Hassan,Elizabeth A. Holly,David J. Hunter,Amy K. Hutchinson,Amy K. Hutchinson,Rebecca D. Jackson,Kevin B. Jacobs,Kevin B. Jacobs,Mazda Jenab,Rudolf Kaaks,Alison P. Klein,Charles Kooperberg,Robert C. Kurtz,Donghui Li,Shannon M. Lynch,Margaret T. Mandelson,Margaret T. Mandelson,Robert R. McWilliams,Julie B. Mendelsohn,Dominique S. Michaud,Dominique S. Michaud,Sara H. Olson,Kim Overvad,Alpa V. Patel,Petra H.M. Peeters,Petra H.M. Peeters,Aleksandar Rajkovic,Elio Riboli,Harvey A. Risch,Xiao-Ou Shu,Gilles Thomas,Geoffrey S. Tobias,Dimitrios Trichopoulos,Dimitrios Trichopoulos,Stephen K. Van Den Eeden,Jarmo Virtamo,Jean Wactawski-Wende,Brian M. Wolpin,Herbert Yu,Kai Yu,Anne Zeleniuch-Jacquotte,Stephen J. Chanock,Patricia Hartge,Robert N. Hoover +77 more
TLDR
An association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 is identified, consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreaticcancer than those with groups A or B.Abstract:
We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.read more
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Journal ArticleDOI
The Epidemiology of Pancreatitis and Pancreatic Cancer
Dhiraj Yadav,Albert B. Lowenfels +1 more
TL;DR: Alcohol abstinence and smoking cessation can alter the progression of pancreatitis and reduce recurrence; smoking cessation is the most effective strategy to reduce the risk of pancreatic cancer.
Journal ArticleDOI
Epidemiology of Pancreatic Cancer: Global Trends, Etiology and Risk Factors.
TL;DR: Up-to-date statistics on pancreatic cancer occurrence and outcome along with a better understanding of the etiology and identifying the causative risk factors are essential for the primary prevention of this disease.
Journal ArticleDOI
Genome-wide association study of circulating vitamin D levels
Jiyoung Ahn,Kai Yu,Rachael Z. Stolzenberg-Solomon,K. Claire Simon,Marjorie L. McCullough,Lisa Gallicchio,Eric J. Jacobs,Alberto Ascherio,Kathy J. Helzlsouer,Kevin B. Jacobs,Qizhai Li,Stephanie J. Weinstein,Mark P. Purdue,Jarmo Virtamo,Ronald L. Horst,William Wheeler,Stephen J. Chanock,David J. Hunter,Richard B. Hayes,Peter Kraft,Demetrius Albanes +20 more
TL;DR: Strong genome-wide significant associations with 25(OH)D are confirmed through meta-analysis with the GWAS data for GC, NADSYN1/DHCR7, CYP2R1 and CYP 2R1, but not C10orf88, the key C-25 hydroxylase that converts vitamin D3 to an active vitamin D receptor ligand.
Journal ArticleDOI
The QTN Program and the Alleles That Matter for Evolution: All That’s Gold Does Not Glitter
TL;DR: It is argued that neither theory nor data justify a view of readily discoverable large‐effect alleles as the primary molecular substrates for evolution, and that evolution often acts via large numbers of small‐effect polygenes, individually undetectable.
Journal ArticleDOI
Bioinformatics challenges for genome-wide association studies
TL;DR: It is argued here that bioinformatics has an important role to play in addressing the complexity of the underlying genetic basis of common human diseases as well as those GWAS challenges that will require computational methods.
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TL;DR: This study has demonstrated that careful use of a shared control group represents a safe and effective approach to GWA analyses of multiple disease phenotypes; generated a genome-wide genotype database for future studies of common diseases in the British population; and shown that, provided individuals with non-European ancestry are excluded, the extent of population stratification in theBritish population is generally modest.
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Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer
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