Giloy Ghanvati (Tinospora cordifolia (Willd.) Hook. f. and Thomson) Reversed SARS-CoV-2 Viral Spike-Protein Induced Disease Phenotype in the Xenotransplant Model of Humanized Zebrafish
TLDR
In this article, the authors have used the aqueous extracts of Tinospora cordifolia (willd.) Hook in the form of Giloy Ghanvati, as a means of treatment to the SARS-CoV-2 spike-protein induced disease phenotype in a humanized zebrafish model.Abstract:
The current Severe Acute Respiratory Syndrome disease caused by Coronavirus-2 (SARS-CoV-2) has been a serious strain on the healthcare infrastructure mainly due to the lack of a reliable treatment option. Alternate therapies aimed at symptomatic relief are currently prescribed along with artificial ventilation to relieve distress. Traditional medicine in the form of Ayurveda has been used since ancient times as a holistic treatment option rather than targeted therapy. The practice of Ayurveda has several potent herbal alternatives for chronic cough, inflammation, and respiratory distress which are often seen in the SARS-CoV-2 infection. In this study we have used the aqueous extracts of Tinospora cordifolia (willd.) Hook. f. and Thomson in the form of Giloy Ghanvati, as a means of treatment to the SARS-CoV-2 spike-protein induced disease phenotype in a humanized zebrafish model. The introduction of spike-protein in the swim bladder transplanted with human lung epithelial cells (A549), caused an infiltration of pro-inflammatory immune cells such as granulocytes and macrophages into the swim bladder. There was also an increased systemic damage as exemplified by renal tissue damage and increased behavioral fever in the disease induction group. These features were reversed in the treatment group, fed with three different dosages of Giloy Ghanvati. The resultant changes in the disease phenotype were comparable to the group that were given the reference compound, Dexamethasone. These findings correlated well with various phyto-compounds detected in the Giloy Ghanvati and their reported roles in the viral disease phenotype amelioration.read more
Citations
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Sachchida N. Rai,Neeraj Tiwari,Payal Singh,Anurag Singh,Divya Mishra,Mohd. Imran,Snigdha Singh,Etrat Hooshmandi,Emanuel Vamanu,Santosh Kumar Singh,Mohan Singh +10 more
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Comparative Retrospective Open-label Study of Ayurvedic Medicines and Their Combination with Allopathic Drugs on Asymptomatic and Mildly-symptomatic COVID-19 Patients.
TL;DR: The potential of Ayurveda, one of the branches of traditional Indian medicine (TIM), employing medicines derived from plants and other natural sources, against COVID-19 has been explored through a comparative retrospective open-label study as mentioned in this paper.
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Curcumin Extraction, Isolation, Quantification and Its Application in Functional Foods: A Review With a Focus on Immune Enhancement Activities and COVID-19.
Soubhagya Tripathy,Deepak Kumar Verma,Mamta Thakur,Ami Patel,Prem Prakash Srivastav,Smita Singh,Smita Singh,Alok Kumar Gupta,Mónica L. Chávez-González,Cristóbal N. Aguilar,Nishant Chakravorty,Henu Kumar Verma,Gemilang Lara Utama +12 more
TL;DR: Curcumin is the natural and safe bioactive compound of the turmeric (Curcuma longa L.) plant and is known to possess potent anti-microbial and immuno-modulatory properties.
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Fifty years of research on Tinospora cordifolia: From botanical plant to functional ingredient in foods
TL;DR: Tinospora cordifolia (giloy) (TC) has been extensively studied in the literature for its health-related properties, elucidating the physiological role in human body and focusing its utilization in food industry as mentioned in this paper.
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