Gut microbiome composition is linked to whole grain-induced immunological improvements
Inés Martínez,James M. Lattimer,Kelcie L. Hubach,Jennifer A Case,Junyi Yang,Casey Weber,Julie A. Louk,Devin J. Rose,Gayaneh Kyureghian,Daniel A. Peterson,Mark D. Haub,Jens Walter +11 more
TLDR
It is revealed that a short-term intake of whole grains induced compositional alterations of the gut microbiota that coincided with improvements in host physiological measures related to metabolic dysfunctions in humans.Abstract:
The involvement of the gut microbiota in metabolic disorders, and the ability of whole grains to affect both host metabolism and gut microbial ecology, suggest that some benefits of whole grains are mediated through their effects on the gut microbiome. Nutritional studies that assess the effect of whole grains on both the gut microbiome and human physiology are needed. We conducted a randomized cross-over trial with four-week treatments in which 28 healthy humans consumed a daily dose of 60 g of whole-grain barley (WGB), brown rice (BR), or an equal mixture of the two (BR+WGB), and characterized their impact on fecal microbial ecology and blood markers of inflammation, glucose and lipid metabolism. All treatments increased microbial diversity, the Firmicutes/Bacteroidetes ratio, and the abundance of the genus Blautia in fecal samples. The inclusion of WGB enriched the genera Roseburia, Bifidobacterium and Dialister, and the species Eubacterium rectale, Roseburia faecis and Roseburia intestinalis. Whole grains, and especially the BR+WGB treatment, reduced plasma interleukin-6 (IL-6) and peak postprandial glucose. Shifts in the abundance of Eubacterium rectale were associated with changes in the glucose and insulin postprandial response. Interestingly, subjects with greater improvements in IL-6 levels harbored significantly higher proportions of Dialister and lower abundance of Coriobacteriaceae. In conclusion, this study revealed that a short-term intake of whole grains induced compositional alterations of the gut microbiota that coincided with improvements in host physiological measures related to metabolic dysfunctions in humans.read more
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Gut microbiota and systemic inflammation changes after bread consumption: The ingredients and the processing influence
Maykel Arias,Marta Cobo,Paula Jaime-Sánchez,Jorge Pastor,Pedro C. Marijuán,Pedro C. Marijuán,Julián Pardo,Antonio Rezusta,Rosa del Campo +8 more
TL;DR: The more consumed industrial processed bread might provoke systemic inflammation, probably in relation with its composition and manufacture process.
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Metabolic networks of the human gut microbiota
Susannah Selber-Hnatiw,Tarin Sultana,W Tse,Niki Abdollahi,Sheyar Abdullah,Jalal Al Rahbani,Diala Alazar,Nekoula Jean Alrumhein,Saro Aprikian,Rimsha Arshad,Jean-Daniel Azuelos,Daphney Bernadotte,Natalie Beswick,Hana Chazbey,Kelsey Church,Emaly Ciubotaru,Lora D'Amato,Tavia Del Corpo,Jasmine Deng,Briana Laura Di Giulio,Diana Diveeva,Elias Elahie,James Gordon Marcel Frank,Emma Furze,Rebecca E. Garner,Vanessa Gibbs,Rachel Goldberg-Hall,Chaim Jacob Goldman,Fani-Fay Goltsios,Kevin Gorjipour,Taylor Grant,Brittany Greco,Nadir Guliyev,Andrew Habrich,Hillary Hyland,Nabila Ibrahim,Tania Iozzo,Anastasia Jawaheer-Fenaoui,Julia Jane Jaworski,Maneet Kaur Jhajj,Jermaine Jones,Rodney Joyette,Samad Kaudeer,Shawn Kelley,Shayesteh Kiani,Marylin Koayes,Abby Johanna Amy-Aminta Léna Kpata,Shannon Maingot,Sara Martin,Kelly Mathers,Sean McCullogh,Kelly McNamara,James Mendonca,Karamat Mohammad,Sharara Arezo Momtaz,Thiban Navaratnarajah,Kathy Nguyen-Duong,Mustafa Omran,Angela Ortiz,Anjali Patel,Kahlila Paul-Cole,Paul-Arthur Plaisir,Jessica Porras Marroquin,Ashlee D. Prévost,Angela Quach,Aries John Rafal,Rewaparsad Ramsarun,Sami Rhnima,Lydia Rili,Naomi Safir,Eugenie Samson,Rebecca Rose Sandiford,Stefano Secondi,Stephanie Shahid,Mojdeh Shahroozi,Fily Sidibe,Megan Smith,Alina Maria Sreng Flores,Anabel Suarez Ybarra,Rebecca Sénéchal,Tarek Taifour,Lawrence Tang,Adam Trapid,Maxim Tremblay Potvin,Justin Wainberg,Dani Ni Wang,Mischa Weissenberg,Allison White,Gabrielle Wilkinson,Brittany Williams,Joshua Roth Wilson,Johanna Zoppi,Katerina Zouboulakis,Chiara Gamberi +93 more
TL;DR: The biology of the dynamic relationship between the reciprocal metabolic state of the microbiota-host entity in balance with its environment is examined, the enzymatic and metabolic changes associated with its imbalance in three well-studied diseases states such as obesity, diabetes and atherosclerosis, and the effects of bariatric surgery and exercise are examined.
Journal ArticleDOI
Whole grains in the renal diet--is it time to reevaluate their role?
TL;DR: The ‘grain ban' in the diet for kidney patients should be reconsidered and the kidney diet would be enriched and it would provide needed fiber along with its health benefits, diversify the diet with low sodium choices, and possibly provide adequate protein without increasing phosphorous levels.
Journal ArticleDOI
Microbial communities mediating algal detritus turnover under anaerobic conditions.
Jessica M. Morrison,Chelsea L. Murphy,Kristina D. Baker,Richard M. Zamor,Steve J. Nikolai,Shawn M. Wilder,Mostafa S. Elshahed,Noha H. Youssef +7 more
TL;DR: The authors' results represent the first systematic survey of microbial communities mediating turnover of algal biomass under anaerobic conditions, and highlights the diversity of lineages putatively involved in the degradation process.
Journal ArticleDOI
Gut microbiota and immunity relevance in eubiosis and dysbiosis
TL;DR: In this article , a review highlights the gut microbiota-immune system cross-talk in both eubiosis and dysbiosis, highlighting the importance of the microbiota in growth and development of the main components of human's adaptive and innate immune system.
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