Gut microbiome composition is linked to whole grain-induced immunological improvements
Inés Martínez,James M. Lattimer,Kelcie L. Hubach,Jennifer A Case,Junyi Yang,Casey Weber,Julie A. Louk,Devin J. Rose,Gayaneh Kyureghian,Daniel A. Peterson,Mark D. Haub,Jens Walter +11 more
TLDR
It is revealed that a short-term intake of whole grains induced compositional alterations of the gut microbiota that coincided with improvements in host physiological measures related to metabolic dysfunctions in humans.Abstract:
The involvement of the gut microbiota in metabolic disorders, and the ability of whole grains to affect both host metabolism and gut microbial ecology, suggest that some benefits of whole grains are mediated through their effects on the gut microbiome. Nutritional studies that assess the effect of whole grains on both the gut microbiome and human physiology are needed. We conducted a randomized cross-over trial with four-week treatments in which 28 healthy humans consumed a daily dose of 60 g of whole-grain barley (WGB), brown rice (BR), or an equal mixture of the two (BR+WGB), and characterized their impact on fecal microbial ecology and blood markers of inflammation, glucose and lipid metabolism. All treatments increased microbial diversity, the Firmicutes/Bacteroidetes ratio, and the abundance of the genus Blautia in fecal samples. The inclusion of WGB enriched the genera Roseburia, Bifidobacterium and Dialister, and the species Eubacterium rectale, Roseburia faecis and Roseburia intestinalis. Whole grains, and especially the BR+WGB treatment, reduced plasma interleukin-6 (IL-6) and peak postprandial glucose. Shifts in the abundance of Eubacterium rectale were associated with changes in the glucose and insulin postprandial response. Interestingly, subjects with greater improvements in IL-6 levels harbored significantly higher proportions of Dialister and lower abundance of Coriobacteriaceae. In conclusion, this study revealed that a short-term intake of whole grains induced compositional alterations of the gut microbiota that coincided with improvements in host physiological measures related to metabolic dysfunctions in humans.read more
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High fiber multigrain supplementation improved disease activity score, circulating inflammatory and oxidative stress biomarkers in rheumatoid arthritis (RA) patients: A randomized human clinical trial
TL;DR: In this paper , the effects of 12 weeks high fiber multigrain supplementation on disease activity scores, circulating inflammatory and oxidative stress biomarkers in patients with RA were investigated, and the role of long-term multi-rain consumption warrants further investigations.
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The Effect of Whole-Grain Diet on the Gut Microbiota of the Elderly Individuals
TL;DR: The use of WG could improve the microbial composition and promote the growth of beneficial microbes, which may be beneficial to the health of the elderly individuals.
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Panax notoginseng-microbiota interactions: from plant cultivation to medicinal application
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Comparative Study of the Effects of Tartary Buckwheat Seed and Sprout Consumption on the Physiological Indices and Gut Microbiota of C57BL/6J Mice
Guohui Nan,Haixia Zhao,Qiong Wu,Lisong Liu,Zichao Guan,Chenglei Li,Hua Fei Wu,Da-Bing Xiang,Qi Wu +8 more
TL;DR: In this article , the safety of Tartary buckwheat seeds (TB) and TBS used as high active ingredients was evaluated in a 6-week study with C57BL/6J mice, and the results showed that TB intake tends to generate negative effects on the gut microbiota and organs.
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