Journal ArticleDOI
Ligand density on nanoparticles: A parameter with critical impact on nanomedicine.
Alaaldin M. Alkilany,Alaaldin M. Alkilany,Lin Zhu,Horst Weller,Alf Mews,Wolfgang J. Parak,Matthias Barz,Neus Feliu +7 more
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TLDR
In this review, viruses as "biological" nanoparticles are analyzed towards their ligand density, which is then compared to the liganddensity of engineered nanoparticles, and results help to understand which ligand densities should be attempted for better targeting.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2019-03-15. It has received 105 citations till now. The article focuses on the topics: Nanomedicine & Ligand.read more
Citations
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Controlled anti-cancer drug release through advanced nano-drug delivery systems: Static and dynamic targeting strategies
TL;DR: This study investigates and analyzes drug delivery and release strategies in the nanoparticle-based treatment of cancer, both mathematically and clinically.
64Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer
Helen Lee,Anthony F. Shields,Barry A. Siegal,Kathy D. Miller,Ian E. Krop,Cynthia X. Ma,Patricia LoRusso,Pamela N. Munster,Karen Campbell,Daniel F. Gaddy,Shannon C. Leonard,Elena Geretti,Stephanie J. Blocker,Dmitri B. Kirpotin,Victor Moyo,Thomas Wickham,Bart S. Hendriks +16 more
TL;DR: Findings provide important evidence and quantification of the EPR effect in human metastatic tumors and support imaging nanoparticle deposition in tumors as a potential means to identify patients well suited for treatment with therapeutic nanoparticles.
Journal ArticleDOI
Cell Membrane-Based Biomimetic Nanoparticles and the Immune System: Immunomodulatory Interactions to Therapeutic Applications.
TL;DR: This review will highlight the relationship between cell membrane-based biomimetic nanoparticles and the immune system, emphasizing the role of tuning the nano-bio interface in the immunomodulation of diseases.
Journal ArticleDOI
A Critical Review of the Use of Surfactant-Coated Nanoparticles in Nanomedicine and Food Nanotechnology
TL;DR: A review of the use of surfactant-coated nanoparticles in nanomedicine and food nanotechnology can be found in this article, where the authors systematically describe these nanoparticles through various sections in order.
Journal ArticleDOI
X-ray-Based Techniques to Study the Nano-Bio Interface
Carlos Sanchez-Cano,Ramon A. Alvarez-Puebla,John M. Abendroth,Tobias Beck,Robert H. Blick,Yuan Cao,Frank Caruso,Indranath Chakraborty,Henry N. Chapman,Chunying Chen,Bruce E. Cohen,Andre L.C. Conceição,David P. Cormode,Daxiang Cui,Kenneth A. Dawson,Gerald Falkenberg,Chunhai Fan,Neus Feliu,Mingyuan Gao,E. Gargioni,Claus C. Glüer,Florian Grüner,Moustapha Hassan,Yong Hu,Yalan Huang,Samuel Huber,Nils Huse,Yanan Kang,Ali Khademhosseini,Thomas F. Keller,Christian Körnig,Nicholas A. Kotov,Dorota Koziej,Xing-Jie Liang,Beibei Liu,Sijin Liu,Yang Liu,Ziyao Liu,Luis M. Liz-Marzán,Xiaowei Ma,Andres Machicote,Wolfgang Maison,Adrian P. Mancuso,Adrian P. Mancuso,Saad Megahed,Bert Nickel,Ferdinand Otto,Cristina Palencia,Sakura Pascarelli,Arwen R. Pearson,Oula Penate-Medina,Bing Qi,Joachim O. Rädler,Joseph J. Richardson,Axel Rosenhahn,Kai Rothkamm,Michael Rübhausen,Milan K. Sanyal,Raymond E. Schaak,Heinz Peter Schlemmer,Marius Schmidt,Oliver Schmutzler,Theo Schotten,Florian Schulz,A. K. Sood,Kathryn Spiers,Theresa Staufer,Dominik M. Stemer,Andreas Stierle,Xing Sun,Xing Sun,Gohar Tsakanova,Paul S. Weiss,Horst Weller,Fabian Westermeier,Ming Xu,Huijie Yan,Yuan Zeng,Ying Zhao,Yuliang Zhao,Dingcheng Zhu,Ying Zhu,Wolfgang J. Parak,Wolfgang J. Parak +83 more
TL;DR: X-ray-based analytics are routinely applied in many fields, including physics, chemistry, materials science, and engineering as discussed by the authors, but the full potential of such techniques in the life sciences and medicine has not yet been fully exploited.
References
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Journal ArticleDOI
Principles of nanoparticle design for overcoming biological barriers to drug delivery
TL;DR: By successively addressing each of the biological barriers that a particle encounters upon intravenous administration, innovative design features can be rationally incorporated that will create a new generation of nanotherapeutics, realizing a paradigmatic shift in nanoparticle-based drug delivery.
Journal ArticleDOI
Analysis of nanoparticle delivery to tumours
Stefan Wilhelm,Anthony J. Tavares,Qin Dai,Seiichi Ohta,Seiichi Ohta,Julie Audet,Harold F. Dvorak,Warren C. W. Chan +7 more
TL;DR: This Perspective explores and explains the fundamental dogma of nanoparticle delivery to tumours and answers two central questions: ‘ how many nanoparticles accumulate in a tumour?’ and ‘how does this number affect the clinical translation of nanomedicines?'
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Doxil®--the first FDA-approved nano-drug: lessons learned.
TL;DR: This review summarizes historical and scientific perspectives of Doxil development and lessons learned from its development and 20 years of its use and demonstrates the obligatory need for applying an understanding of the cross talk between physicochemical, nano-technological, and biological principles.
Journal ArticleDOI
Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
TL;DR: This work has shown that addition of PEG and PEG-containing copolymers to the surface of nanoparticles results in an increase in the blood circulation half-life of the particles by several orders of magnitude, and creates a hydrophilic protective layer around the nanoparticles that is able to repel the absorption of opsonin proteins via steric repulsion forces.
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PEGylation as a strategy for improving nanoparticle-based drug and gene delivery
TL;DR: The history of the development of PEGylated nanoparticle formulations for systemic administration is described, including how factors such as PEG molecular weight, PEG surface density, nanoparticle core properties, and repeated administration impact circulation time.
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