Journal ArticleDOI
Lipoprotein(a): new insights from modern genomics.
Mehdi Afshar,George Thanassoulis +1 more
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Lp(a), the strongest independent genetic risk factor for both myocardial infarction and aortic stenosis, is poised to gain significant clinical relevance and its lowering could have a significant impact on the burden of CVD.Abstract:
Purpose of review Lipoprotein(a) [Lp(a)] is the strongest independent genetic risk factor for both myocardial infarction and aortic stenosis. It has also been associated with other forms of atherosclerotic cardiovascular disease (CVD) including ischemic stroke. Its levels are genetically determined and remain fairly stable throughout life. Elevated Lp(a), above 50 mg/dl, affects one in five individuals worldwide. Recent findings Herein, we review the recent epidemiologic and genetic evidence supporting the causal role of Lp(a) in CVD, highlight recommendations made by European and Canadian guidelines regarding Lp(a) and summarize the rapidly evolving field of Lp(a)-lowering therapies including antisense therapies and Proprotein Convertase Subtilisin/Kexin Type 9 inhibitors. Summary With novel therapies on the horizon, Lp(a) is poised to gain significant clinical relevance and its lowering could have a significant impact on the burden of CVD. VIDEO ABSTRACT.read more
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Effects of coenzyme Q10 supplementation on inflammatory markers: A systematic review and meta-analysis of randomized controlled trials.
TL;DR: This meta‐analysis of RCTs suggests significant lowering effects of CoQ10 on CRP, IL‐6 and TNF‐&agr;, however, results should be interpreted with caution because of the evidence of heterogeneity and limited number of studies.
Journal ArticleDOI
Hypertriglyceridemia and cardiovascular risk: a cautionary note about metabolic confounding
Allan D. Sniderman,Patrick Couture,Seth S. Martin,Jacqueline DeGraaf,Patrick R. Lawler,William C. Cromwell,John T. Wilkins,George Thanassoulis +7 more
TL;DR: This work will examine the validity of the triglyceride hypothesis by detailing the biological complexities associated with hypertriglyceridemia, the genetic epidemiological evidence in favor of hypertrigovernmental triglycerides, the evidence from the fibrate randomized clinical trials relating triglycerides and clinical outcomes, and the completeness of theevidence from the initial studies of novel mutations.
Journal ArticleDOI
Lipoprotein(a): An independent, genetic, and causal factor for cardiovascular disease and acute myocardial infarction.
TL;DR: The 2018 Cholesterol Clinical Practice Guideline have recognized elevated Lp(a) as an atherosclerotic cardiovascular disease risk enhancer for initiating or intensifying statin therapy.
Journal ArticleDOI
Dyslipidemia Management in Adults With Diabetes
Julieta Lazarte,Robert A. Hegele +1 more
TL;DR: Several existing and newer drug treatments reduce ASCVD risk through LDL cholesterol and/or triglyceride reduction in patients with diabetes through statin treatment and novel approaches using antisense oligonucleotides and monoclonal antibodies may provide potential future therapies for diabetic dyslipidemia.
Journal ArticleDOI
Role of DNA copy number variation in dyslipidemias.
TL;DR: CNVs account for large proportion of human genetic variation and are already known to contribute to susceptibility of dyslipidemias, particularly in about 10% of familial hypercholesterolemia patients.
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Journal ArticleDOI
Large-scale association analysis identifies new risk loci for coronary artery disease
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TL;DR: An association analysis in CAD cases and controls identifies 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants strongly associated with CAD at a 5% false discovery rate (FDR).
Journal ArticleDOI
Lipoprotein(a) as a cardiovascular risk factor: current status
Børge G. Nordestgaard,M. John Chapman,Kausik K. Ray,Jan Borén,Felicita Andreotti,Gerald F. Watts,Henry N. Ginsberg,Pierre Amarenco,Alberico L. Catapano,Olivier S. Descamps,Edward A. Fisher,Petri T. Kovanen,Jan Albert Kuivenhoven,Philippe Lesnik,Luis Masana,Zeljko Reiner,Marja-Riitta Taskinen,Lale Tokgozoglu,Anne Tybjærg-Hansen +18 more
TL;DR: The robust and specific association between elevated Lp(a) levels and increased cardiovascular disease (CVD)/coronary heart disease (CHD) risk, together with recent genetic findings, indicates that elevated LP(a), like elevated LDL-cholesterol, is causally related to premature CVD/CHD.
Journal ArticleDOI
Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality.
Sebhat Erqou,Stephen Kaptoge,P Perry,E Di Angelantonio,Alexander M. W. Cargill Thompson,Ian R. White,Santica M. Marcovina,Rory Collins,Simon G. Thompson,John Danesh +9 more
TL;DR: Under a wide range of circumstances, there are continuous, independent, and modest associations of Lp(a) concentration with risk of CHD and stroke that appear exclusive to vascular outcomes.
Journal ArticleDOI
Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease
Robert Clarke,John F. Peden,J C Hopewell,Theodosios Kyriakou,Anuj Goel,Simon Heath,Sarah Parish,Simona Barlera,MariaGrazia Franzosi,Stephan Rust,Derrick A Bennett,Angela Silveira,Anders Mälarstig,Fiona R. Green,M Lathrop,Bruna Gigante,Karin Leander,U de Faire,Udo Seedorf,Anders Hamsten,Rory Collins,Hugh Watkins,Martin Farrall +22 more
TL;DR: Two LPA variants were strongly associated with both an increased level of Lp(a) lipoprotein and an increased risk of coronary disease, and the association between the LPA genotype score and the risk of heart disease was abolished.
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