Live-Cell Chromosome Dynamics and Outcome of X Chromosome Pairing Events during ES Cell Differentiation
Osamu Masui,Osamu Masui,Osamu Masui,Isabelle Bonnet,Isabelle Bonnet,Isabelle Bonnet,Patricia Le Baccon,Patricia Le Baccon,Isabel Brito,Isabel Brito,Isabel Brito,Tim Pollex,Tim Pollex,Tim Pollex,Niall Murphy,Niall Murphy,Niall Murphy,Philippe Hupé,Emmanuel Barillot,Emmanuel Barillot,Emmanuel Barillot,Andrew S. Belmont,Edith Heard,Edith Heard,Edith Heard +24 more
TLDR
The findings reveal the spatiotemporal choreography of the X chromosomes during early differentiation and indicate a direct role for pairing in facilitating symmetry-breaking and monoallelic regulation of Xist during random X inactivation.About:
This article is published in Cell.The article was published on 2011-04-29 and is currently open access. It has received 143 citations till now. The article focuses on the topics: Tsix & XIST.read more
Citations
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The 3D Genome as Moderator of Chromosomal Communication
Job Dekker,Leonid A. Mirny +1 more
TL;DR: A view of the interphase 3D genome characterized by extensive physical compartmentalization and insulation on the one hand and facilitated long-range interactions on the other is presented.
Journal ArticleDOI
Biogenesis and function of nuclear bodies
TL;DR: Understanding the functional relationships between the 3D organization of the genome and nuclear bodies is essential to fully uncover the regulation of gene expression and its implications for human disease.
The 3D Genome as Moderator of Chromosomal Communication
Job Dekker,Leonid A. Mirny +1 more
TL;DR: In this article, the authors present a view of the interphase 3D genome characterized by extensive physical compartmentalization and insulation on the one hand and facilitated long-range interactions on the other.
Long-Range Directional Movement of an Interphase Chromosome Site Dependent on Actin and Nuclear Myosin
TL;DR: The results suggest an active mechanism for fast and directed long-range interphase chromosome movements dependent directly or indirectly on actin/myosin.
Journal ArticleDOI
Predictive Polymer Modeling Reveals Coupled Fluctuations in Chromosome Conformation and Transcription
Luca Giorgetti,Luca Giorgetti,Luca Giorgetti,Rafael Galupa,Rafael Galupa,Rafael Galupa,Elphège P. Nora,Tristan Piolot,Tristan Piolot,Tristan Piolot,Job Dekker,Guido Tiana,Edith Heard +12 more
TL;DR: It is demonstrated that contacts between potential regulatory elements occur in the context of fluctuating structures rather than stable loops and proposed that such fluctuations may contribute to asymmetric expression in the Xic during X inactivation.
References
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Gene Action in the X -chromosome of the Mouse ( Mus musculus L.)
TL;DR: Ohno and Hauschka1 showed that in female mice one chromosome of mammary carcinoma cells and of normal diploid cells of the ovary, mammary gland and liver was heteropyKnotic and suggested that the so-called sex chromatin was composed of one heteropyknotic X-chromosome.
Journal ArticleDOI
Cohesins: chromosomal proteins that prevent premature separation of sister chromatids
TL;DR: Three chromosmal proteins that prevent premature separation of sister chromatids in yeast are described, two of which are members of the SMC family, which are putative ATPases with coiled-coil domains.
Journal ArticleDOI
Requirement for Xist in X chromosome inactivation
Graeme D. Penny,Graham F. Kay,Graham F. Kay,Steven A. Sheardown,Sohaila Rastan,Sohaila Rastan,Neil Brockdorff +6 more
TL;DR: Evidence for gene targeting of Xist, the proposed candidate for the X inactivation centre, is provided, and its absolute requirement in the process of X chromosome inactivation is provided.
Journal ArticleDOI
Single particle tracking. Analysis of diffusion and flow in two-dimensional systems.
TL;DR: The single particle tracking method, based on observations of the trajectories of individual particles, is compared with methods that characterize the motions of a large collection of particles such as fluorescence photobleaching recovery.
Journal ArticleDOI
Hyperdynamic Plasticity of Chromatin Proteins in Pluripotent Embryonic Stem Cells
Eran Meshorer,Dhananjay Yellajoshula,Eric M. George,Peter J. Scambler,David T. Brown,Tom Misteli +5 more
TL;DR: It is suggested that hyperdynamic binding of structural chromatin proteins is a functionally important hallmark of pluripotent ES cells that contributes to the maintenance of plasticity in undifferentiated ES cells and to establishing higher-order chromatin structure.
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