lncRNA H19 regulates epithelial-mesenchymal transition and metastasis of bladder cancer by miR-29b-3p as competing endogenous RNA.
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TLDR
It is demonstrated for the first time that H19 might function as ceRNA (competing endogenous RNA) for miR-29b-3p and relieve the suppression for DNMT3B, which led to EMT and metastasis of BC.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2017-10-01 and is currently open access. It has received 181 citations till now. The article focuses on the topics: Epithelial–mesenchymal transition & Competing endogenous RNA.read more
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Noncoding RNA:RNA Regulatory Networks in Cancer.
Jia Jia Chan,Yvonne Tay +1 more
TL;DR: Recent integrative analyses have provided evidence that new computational platforms and experimental approaches can be harnessed together to distinguish key ceRNA interactions in specific cancers, which could facilitate the identification of robust biomarkers and therapeutic targets, and hence, more effective cancer therapies and better patient outcome and survival.
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Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19
Jing Ren,Liang Ding,Dongya Zhang,Guoping Shi,Qianyun Xu,Sunan Shen,Yaping Wang,Tingting Wang,Yayi Hou +8 more
TL;DR: It is indicated that H19 expressed by CAFs of the colorectal tumor stroma contributes to tumor development and chemoresistance and up-regulation of H19 was confirmed in CRC patient samples at different tumor node metastasis (TNM) stages.
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Clinical utility of circulating non-coding RNAs — an update
TL;DR: A compendium of miRNAs and long ncRNAs that have been reported in the literature to be present in human body fluids and that have the potential to be used as diagnostic and prognostic cancer biomarkers is provided.
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H19 lncRNA: Roles in tumorigenesis.
TL;DR: Taken together, H19 is regarded as a biomarker for cancer and a putative therapeutic target in these human disorders.
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LncRNAs regulate the cytoskeleton and related Rho/ROCK signaling in cancer metastasis
Yanyan Tang,Yanyan Tang,Yi He,Yi He,Ping Zhang,Ping Zhang,Jinpeng Wang,Chunmei Fan,Liting Yang,Fang Xiong,Shanshan Zhang,Shanshan Zhang,Zhaojian Gong,Shaolin Nie,Qianjin Liao,Qianjin Liao,Xiayu Li,Xiayu Li,Xiaoling Li,Xiaoling Li,Yong Li,Guiyuan Li,Guiyuan Li,Zhaoyang Zeng,Zhaoyang Zeng,Wei Xiong,Wei Xiong,Can Guo,Can Guo +28 more
TL;DR: This review focuses on the regulatory association between lncRNAs and the cytoskeleton and discusses the pathways and mechanisms involved in the regulation of cancer metastasis.
References
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A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
TL;DR: It is proposed that this "competing endogenous RNA" (ceRNA) activity forms a large-scale regulatory network across the transcriptome, greatly expanding the functional genetic information in the human genome and playing important roles in pathological conditions, such as cancer.
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MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B.
Muller Fabbri,Ramiro Garzon,Amelia Cimmino,Amelia Cimmino,Zhongfa Liu,Nicola Zanesi,Elisa Callegari,Shujun Liu,Hansjuerg Alder,Stefan Costinean,Cecilia Fernandez-Cymering,Stefano Volinia,Gulnur Guler,Carl Morrison,Kenneth K. Chan,Guido Marcucci,George A. Calin,Kay Huebner,Carlo M. Croce +18 more
TL;DR: The enforced expression of miR-29s in lung cancer cell lines restores normal patterns of DNA methylation, induces reexpression of methylation-silenced tumor suppressor genes, and inhibits tumorigenicity in vitro and in vivo.
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A Long Noncoding RNA Activated by TGF-β Promotes the Invasion-Metastasis Cascade in Hepatocellular Carcinoma
Ji-hang Yuan,Fu Yang,Fang Wang,Jin-zhao Ma,Yingjun Guo,Qi-fei Tao,Feng Liu,Wei Pan,Tian-tian Wang,Chuan-chuan Zhou,Shao-bing Wang,Yu-zhao Wang,Yuan Yang,Ning Yang,Weiping Zhou,Guang-Shun Yang,Shuhan Sun +16 more
TL;DR: Findings suggest that lncRNA-ATB, a mediator of TGF-β signaling, could predispose HCC patients to metastases and may serve as a potential target for antimetastatic therapies.
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The imprinted H19 lncRNA antagonizes let-7 microRNAs.
Amanda N. Kallen,Xiao-Bo Zhou,Xiao-Bo Zhou,Jie Xu,Chong Qiao,Chong Qiao,Jing Ma,Jing Ma,Lei Yan,Lei Yan,Lingeng Lu,Chaochun Liu,Jae Sung Yi,Haifeng Zhang,Wang Min,Anton M. Bennett,Richard I. Gregory,Ye Ding,Yingqun Huang +18 more
TL;DR: It is demonstrated that H19 modulates let-7 availability by acting as a molecular sponge, and this lncRNA is identified as an important regulator of the majorLet-7 family of microRNAs.
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A Cytoplasmic NF-κB Interacting Long Noncoding RNA Blocks IκB Phosphorylation and Suppresses Breast Cancer Metastasis
Bodu Liu,Lijuan Sun,Qiang Liu,Chang Gong,Yandan Yao,Xiao-Bin Lv,Ling Lin,Herui Yao,Fengxi Su,Dangsheng Li,Mu Sheng Zeng,Erwei Song +11 more
TL;DR: This work identifies an NF-KappaB Interacting LncRNA (NKILA), which is upregulated by NF-κB, binds to NF-σκB/IκBs, and directly masks phosphorylation motifs of IKKB, thereby inhibiting IKK-induced IκBosphorylation and NF-kkB activation.