The imprinted H19 lncRNA antagonizes let-7 microRNAs.
Amanda N. Kallen,Xiao-Bo Zhou,Xiao-Bo Zhou,Jie Xu,Chong Qiao,Chong Qiao,Jing Ma,Jing Ma,Lei Yan,Lei Yan,Lingeng Lu,Chaochun Liu,Jae Sung Yi,Haifeng Zhang,Wang Min,Anton M. Bennett,Richard I. Gregory,Ye Ding,Yingqun Huang +18 more
TLDR
It is demonstrated that H19 modulates let-7 availability by acting as a molecular sponge, and this lncRNA is identified as an important regulator of the majorLet-7 family of microRNAs.About:
This article is published in Molecular Cell.The article was published on 2013-10-10 and is currently open access. It has received 920 citations till now. The article focuses on the topics: Long non-coding RNA & Regulation of gene expression.read more
Citations
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The multilayered complexity of ceRNA crosstalk and competition
TL;DR: Understanding this novel RNA crosstalk will lead to significant insight into gene regulatory networks and have implications in human development and disease.
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Long non-coding RNAs: new players in cell differentiation and development
Alessandro Fatica,Irene Bozzoni +1 more
TL;DR: The function of lncRNAs in developmental processes, such as in dosage compensation, genomic imprinting, cell differentiation and organogenesis, with a particular emphasis on mammalian development are described.
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Long Noncoding RNAs in Cancer Pathways
Adam M. Schmitt,Howard Y. Chang +1 more
TL;DR: It is understood that lncRNAs drive many important cancer phenotypes through their interactions with other cellular macromolecules including DNA, protein, and RNA, making these molecules attractive targets for therapeutic intervention in the fight against cancer.
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Non-coding RNA networks in cancer.
TL;DR: A deeper understanding of the complex networks of interactions that ncRNAs coordinate would provide a unique opportunity to design better therapeutic interventions.
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The Role of Non-coding RNAs in Oncology
TL;DR: For decades, research into cancer biology focused on the involvement of protein-coding genes, but an explosion of studies into ncRNA biology has shown that they represent a diverse and prevalent group of RNAs, including both oncogenic molecules and those that work in a tumor suppressive manner.
References
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