Journal ArticleDOI
Mechanisms and regulation of endothelial VEGF receptor signalling
TLDR
A clear understanding of the tight and multi-level regulation of VEGFR2 signalling is key to successful therapeutic suppression or stimulation of vascular growth.Abstract:
Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are uniquely required to balance the formation of new blood vessels with the maintenance and remodelling of existing ones, during development and in adult tissues. Recent advances have greatly expanded our understanding of the tight and multi-level regulation of VEGFR2 signalling, which is the primary focus of this Review. Important insights have been gained into the regulatory roles of VEGFR-interacting proteins (such as neuropilins, proteoglycans, integrins and protein tyrosine phosphatases); the dynamics of VEGFR2 endocytosis, trafficking and signalling; and the crosstalk between VEGF-induced signalling and other endothelial signalling cascades. A clear understanding of this multifaceted signalling web is key to successful therapeutic suppression or stimulation of vascular growth.read more
Citations
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Journal ArticleDOI
Neuropilin-1 is a host factor for SARS-CoV-2 infection.
James L. Daly,Boris Simonetti,Katja Klein,Kai-En Chen,Maia Kavanagh Williamson,Carlos Antón-Plágaro,Deborah K. Shoemark,Lorena Simón-Gracia,Michael Bauer,Reka Hollandi,Urs F. Greber,Peter Horvath,Peter Horvath,Richard B. Sessions,Ari Helenius,Julian A. Hiscox,Julian A. Hiscox,Tambet Teesalu,David A. Matthews,Andrew D. Davidson,Brett M. Collins,Peter J. Cullen,Yohei Yamauchi,Yohei Yamauchi +23 more
TL;DR: It is shown that neuropilin-1 (NRP1), which is known to bind furin-cleaved substrates, potentiates SARS-CoV-2 infectivity and serves as a host factor for Sars-Cov-2 infection and may potentially provide a therapeutic target for COVID-19.
Posted ContentDOI
Neuropilin-1 is a host factor for SARS-CoV-2 infection
James L. Daly,Boris Simonetti,Carlos Antón-Plágaro,Maia Kavanagh Williamson,Deborah K. Shoemark,Lorena Simón-Gracia,Katja Klein,Michael Bauer,Reka Hollandi,Urs F. Greber,Peter Horvath,Richard B. Sessions,Ari Helenius,Julian A. Hiscox,Tambet Teesalu,David A. Matthews,Andrew D. Davidson,Peter J. Cullen,Yohei Yamauchi +18 more
TL;DR: Here it is demonstrated using immunoprecipitation, site-specific mutagenesis, structural modelling, and antibody blockade that S1 can bind to NRP1 through the canonical CendR mechanism, and this interaction enhances infection by SARS-CoV-2 in cell culture.
Journal ArticleDOI
Targeting VEGF/VEGFR to Modulate Antitumor Immunity.
Ju Yang,Jing Yan,Baorui Liu +2 more
TL;DR: A review of the latest clinical and preclinical findings on the modulatory role of antiangiogenic agents targeting VEGF/VEGFR in immune cells, including effector T cells, Tregs, MDSCs, DCs, tumor-associated macrophages, and mast cells will be potentially helpful for the development of combinations of angiogenesis inhibitors with immunological modulators.
Journal ArticleDOI
Vascular heterogeneity and specialization in development and disease.
Michael Potente,Taija Makinen +1 more
TL;DR: How endothelial cells interact with each other and with their tissue environment is illuminated, providing paradigms for vessel type- and organ-specific endothelial differentiation and crucial for understanding how tissues develop and maintain, and how their function becomes abnormal in disease.
Journal ArticleDOI
Improving immunotherapy outcomes with anti-angiogenic treatments and vice versa.
Kabir A. Khan,Robert S. Kerbel +1 more
TL;DR: It is proposed that interactions between both therapeutic modalities could be considered a 'two-way street' and increase the efficacy of immunotherapies or other types of antivascular therapies and/or promote changes in the tumour vasculature.
References
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