Mechanochemistry: opportunities for new and cleaner synthesis
Stuart L. James,Christopher J. Adams,Carsten Bolm,Dario Braga,Paul Collier,Tomislav Friščić,Fabrizia Grepioni,Kenneth D. M. Harris,Geoff Hyett,William Jones,Anke Krebs,James Mack,Lucia Maini,A. Guy Orpen,Ivan P. Parkin,William C. Shearouse,Jonathan W. Steed,Daniel C. Waddell +17 more
TLDR
Concentrating on recent advances, this article covers industrial aspects, inorganic materials, organic synthesis, cocrystallisation, pharmaceutical aspects, metal complexes, supramolecular aspects and characterization methods.Abstract:
The aim of this critical review is to provide a broad but digestible overview of mechanochemical synthesis, i.e. reactions conducted by grinding solid reactants together with no or minimal solvent. Although mechanochemistry has historically been a sideline approach to synthesis it may soon move into the mainstream because it is increasingly apparent that it can be practical, and even advantageous, and because of the opportunities it provides for developing more sustainable methods. Concentrating on recent advances, this article covers industrial aspects, inorganic materials, organic synthesis, cocrystallisation, pharmaceutical aspects, metal complexes (including metal–organic frameworks), supramolecular aspects and characterization methods. The historical development, mechanistic aspects, limitations and opportunities are also discussed (314 references).read more
Citations
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Transformation of Contact‐Explosives Primary Amines and Iodine(III) into a Successful Chemical Reaction under Solvent‐Free Ball Milling Conditions
Tapas Kumar Achar,Prasenjit Mal +1 more
Journal ArticleDOI
Main group mechanochemistry.
TL;DR: An overview of recent advances and achievements in mechanochemistry are provided that further validate mechanochemistry as a credible alternative to solution-based methods for the synthesis of main group compounds and frameworks.
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Grinding as Solvent-Free Green Chemistry Approach for Cyclodextrin Inclusion Complex Preparation in the Solid State.
Mario Jug,Paola Mura +1 more
TL;DR: A systematic overview of the currently available data in this field of mechanochemical activation by grinding for cyclodextrin inclusion complex preparation in the solid state is given, highlighting both the advantages as well as the shortcomings of such an approach.
Journal ArticleDOI
Insights into Mechanochemical Reactions at Targetable and Stable, Sub-ambient Temperatures.
Joel Andersen,James Mack +1 more
TL;DR: Using the reduction of 4-tert-butylcyclohexanone as a model system, the diastereomeric product distribution bore a strong dependence on the selected temperature, and stereoselectivity showed a dependence on operating frequency, although the nature of this dependence remains unclear.
Journal ArticleDOI
Mechanosynthesis of a Copper Complex for Redox Initiating Systems with a Unique Near Infrared Light Activation
Patxi Garra,Frédéric Dumur,Fabrice Morlet-Savary,Céline Dietlin,Didier Gigmes,Jean-Pierre Fouassier,Jacques Lalevée +6 more
TL;DR: In this paper, the first use of a mechanosynthesized copper complex (Cu(acac)(2dppba)) as an initiator for the redox and redox photoactivated polymerization of methacrylates under air is proposed.
References
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A profile refinement method for nuclear and magnetic structures
TL;DR: In this paper, a structure refinement method was described which does not use integrated neutron powder intensities, single or overlapping, but employs directly the profile intensities obtained from step-scanning measurements of the powder diagram.
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A chemically functionalizable nanoporous material (Cu3(TMA)2(H2O)3)n
TL;DR: In this paper, a highly porous metal coordination polymer [Cu3(TMA)2(H2O)3]n (where TMA is benzene-1,3,5-tricarboxylate) was formed in 80 percent yield.
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The Sonogashira Reaction: A Booming Methodology in Synthetic Organic Chemistry†
Rafael Chinchilla,Carmen Nájera +1 more
TL;DR: Transition-Metal-Free Reactions, Alkynylation of Heterocycles, and Synthesis of Electronic and Electrooptical Molecules: A Review.
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TL;DR: A set of general guidelines for structure refinement using the Rietveld (whole profile) method has been formulated by the International Union of Crystallography Commission on Powder Diffraction.