Mechanochemistry: opportunities for new and cleaner synthesis
Stuart L. James,Christopher J. Adams,Carsten Bolm,Dario Braga,Paul Collier,Tomislav Friščić,Fabrizia Grepioni,Kenneth D. M. Harris,Geoff Hyett,William Jones,Anke Krebs,James Mack,Lucia Maini,A. Guy Orpen,Ivan P. Parkin,William C. Shearouse,Jonathan W. Steed,Daniel C. Waddell +17 more
TLDR
Concentrating on recent advances, this article covers industrial aspects, inorganic materials, organic synthesis, cocrystallisation, pharmaceutical aspects, metal complexes, supramolecular aspects and characterization methods.Abstract:
The aim of this critical review is to provide a broad but digestible overview of mechanochemical synthesis, i.e. reactions conducted by grinding solid reactants together with no or minimal solvent. Although mechanochemistry has historically been a sideline approach to synthesis it may soon move into the mainstream because it is increasingly apparent that it can be practical, and even advantageous, and because of the opportunities it provides for developing more sustainable methods. Concentrating on recent advances, this article covers industrial aspects, inorganic materials, organic synthesis, cocrystallisation, pharmaceutical aspects, metal complexes (including metal–organic frameworks), supramolecular aspects and characterization methods. The historical development, mechanistic aspects, limitations and opportunities are also discussed (314 references).read more
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One-step ligand exchange and switching from hydrophobic to water-stable hydrophilic superparamagnetic iron oxide nanoparticles by mechanochemical milling
Katalin V. Korpany,Cristina Mottillo,Jill Bachelder,Shoronia N. Cross,Pengcheng Dong,Simon Trudel,Tomislav Friščić,Amy Szuchmacher Blum +7 more
TL;DR: Application of milling for IONP ligand exchange eliminates steps required for transforming hydrophobic into negatively charged, water-soluble superparamagnetic IONPs.
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Preparation of a crystalline salt of indomethacin and tromethamine by hot melt extrusion technology.
TL;DR: It is shown that the dissolution rate of indomethacin (a poorly water‐soluble drug) can be increased by using hot melt extrusion of a 1:1 indometHacin:tromethamine mixture to form a highly crystalline salt, the physicochemical properties of which are investigated in detail.
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Co-precipitation with CaCO3 to remove heavy metals and significantly reduce the moisture content of filter residue.
Xuewei Li,Qiwu Zhang,Bo Yang +2 more
TL;DR: The results showed that the synergies of the metal ions led to efficient co-precipitation and the neutral pH obtained by using CaCO3 rather than the highly alkaline pH obtained using lime (Ca(OH)2) neutralization method.
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Cu on porous glass: An easily recyclable catalyst for the microwave-assisted azide–alkyne cycloaddition in water
TL;DR: In this article, a 2.5-eV-shift of the binding energy of the Cu 2p core levels in the catalysts' XPS spectra and the disappearance of satellite peaks led to the assumption that reduction of Cu(II) to Cu(I) or Cu(0) occurred during catalyst application.
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Halogen bonding of the aldehyde oxygen atom in cocrystals of aromatic aldehydes and 1,4-diiodotetrafluorobenzene
TL;DR: In this paper, the halogen bond acceptor potential of the aldehyde group oxygen atom in competition with the hydroxy, methoxy and pyridine groups was analyzed.
References
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A profile refinement method for nuclear and magnetic structures
TL;DR: In this paper, a structure refinement method was described which does not use integrated neutron powder intensities, single or overlapping, but employs directly the profile intensities obtained from step-scanning measurements of the powder diagram.
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A chemically functionalizable nanoporous material (Cu3(TMA)2(H2O)3)n
TL;DR: In this paper, a highly porous metal coordination polymer [Cu3(TMA)2(H2O)3]n (where TMA is benzene-1,3,5-tricarboxylate) was formed in 80 percent yield.
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The Sonogashira Reaction: A Booming Methodology in Synthetic Organic Chemistry†
Rafael Chinchilla,Carmen Nájera +1 more
TL;DR: Transition-Metal-Free Reactions, Alkynylation of Heterocycles, and Synthesis of Electronic and Electrooptical Molecules: A Review.
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Asymmetric enamine catalysis.
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Rietveld refinement guidelines
TL;DR: A set of general guidelines for structure refinement using the Rietveld (whole profile) method has been formulated by the International Union of Crystallography Commission on Powder Diffraction.