Mechanochemistry: opportunities for new and cleaner synthesis
Stuart L. James,Christopher J. Adams,Carsten Bolm,Dario Braga,Paul Collier,Tomislav Friščić,Fabrizia Grepioni,Kenneth D. M. Harris,Geoff Hyett,William Jones,Anke Krebs,James Mack,Lucia Maini,A. Guy Orpen,Ivan P. Parkin,William C. Shearouse,Jonathan W. Steed,Daniel C. Waddell +17 more
TLDR
Concentrating on recent advances, this article covers industrial aspects, inorganic materials, organic synthesis, cocrystallisation, pharmaceutical aspects, metal complexes, supramolecular aspects and characterization methods.Abstract:
The aim of this critical review is to provide a broad but digestible overview of mechanochemical synthesis, i.e. reactions conducted by grinding solid reactants together with no or minimal solvent. Although mechanochemistry has historically been a sideline approach to synthesis it may soon move into the mainstream because it is increasingly apparent that it can be practical, and even advantageous, and because of the opportunities it provides for developing more sustainable methods. Concentrating on recent advances, this article covers industrial aspects, inorganic materials, organic synthesis, cocrystallisation, pharmaceutical aspects, metal complexes (including metal–organic frameworks), supramolecular aspects and characterization methods. The historical development, mechanistic aspects, limitations and opportunities are also discussed (314 references).read more
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Mechanochemical synthesis of metal–organic frameworks
TL;DR: In this paper, the authors summarize the typical advances in the mechanochemical synthesis of MOFs over the last two decades and present a mini review of these advances, as well as a discussion of the potential uses in gas adsorption, separation, and catalysis.
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Pharmaceutical Cocrystals: New Solid Phase Modification Approaches for the Formulation of APIs.
TL;DR: An overview of pharmaceutical cocry crystals is presented, with an emphasis on the intermolecular interactions in cocrystals and the methods for their preparation.
Journal ArticleDOI
Synthesis of metal–organic frameworks by continuous flow
Peter A. Bayliss,Ilich A. Ibarra,Ilich A. Ibarra,Eduardo Pérez,Sihai Yang,Chiu C. Tang,Martyn Poliakoff,Martin Schröder +7 more
TL;DR: In this paper, a continuous flow process for the synthesis of a metal-organic framework using only water as the reaction medium and requiring only short residence times is described, which affords a new route to scale-up of materials incorporating many of the principles of Green Chemistry.
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Screening for new pharmaceutical solid forms using mechanochemistry: A practical guide.
Dritan Hasa,William Jones +1 more
TL;DR: This review focuses on particular practical aspects of mechanochemistry in order to allow full optimisation of the approach in searches for new solid forms including polymorphs, salts and cocrystals as well as their solvated/hydrated analogues.
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Mechanochemical Iridium(III)-Catalyzed C-H Bond Amidation of Benzamides with Sulfonyl Azides under Solvent-Free Conditions in a Ball Mill.
TL;DR: Mechanochemical conditions have been applied to an iridium(III)-catalyzed C-H bond amidation process for the first time and this method constitutes a powerful, fast, and environmentally benign alternative to the common solvent-based standard approaches.
References
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A profile refinement method for nuclear and magnetic structures
TL;DR: In this paper, a structure refinement method was described which does not use integrated neutron powder intensities, single or overlapping, but employs directly the profile intensities obtained from step-scanning measurements of the powder diagram.
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A chemically functionalizable nanoporous material (Cu3(TMA)2(H2O)3)n
TL;DR: In this paper, a highly porous metal coordination polymer [Cu3(TMA)2(H2O)3]n (where TMA is benzene-1,3,5-tricarboxylate) was formed in 80 percent yield.
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The Sonogashira Reaction: A Booming Methodology in Synthetic Organic Chemistry†
Rafael Chinchilla,Carmen Nájera +1 more
TL;DR: Transition-Metal-Free Reactions, Alkynylation of Heterocycles, and Synthesis of Electronic and Electrooptical Molecules: A Review.
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Rietveld refinement guidelines
TL;DR: A set of general guidelines for structure refinement using the Rietveld (whole profile) method has been formulated by the International Union of Crystallography Commission on Powder Diffraction.