Mechanochemistry: opportunities for new and cleaner synthesis
Stuart L. James,Christopher J. Adams,Carsten Bolm,Dario Braga,Paul Collier,Tomislav Friščić,Fabrizia Grepioni,Kenneth D. M. Harris,Geoff Hyett,William Jones,Anke Krebs,James Mack,Lucia Maini,A. Guy Orpen,Ivan P. Parkin,William C. Shearouse,Jonathan W. Steed,Daniel C. Waddell +17 more
TLDR
Concentrating on recent advances, this article covers industrial aspects, inorganic materials, organic synthesis, cocrystallisation, pharmaceutical aspects, metal complexes, supramolecular aspects and characterization methods.Abstract:
The aim of this critical review is to provide a broad but digestible overview of mechanochemical synthesis, i.e. reactions conducted by grinding solid reactants together with no or minimal solvent. Although mechanochemistry has historically been a sideline approach to synthesis it may soon move into the mainstream because it is increasingly apparent that it can be practical, and even advantageous, and because of the opportunities it provides for developing more sustainable methods. Concentrating on recent advances, this article covers industrial aspects, inorganic materials, organic synthesis, cocrystallisation, pharmaceutical aspects, metal complexes (including metal–organic frameworks), supramolecular aspects and characterization methods. The historical development, mechanistic aspects, limitations and opportunities are also discussed (314 references).read more
Citations
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The Halogen Bond
Gabriella Cavallo,Pierangelo Metrangolo,Pierangelo Metrangolo,Roberto Milani,Tullio Pilati,Arri Priimagi,Giuseppe Resnati,Giancarlo Terraneo +7 more
TL;DR: The specific advantages brought up by a design based on the use of the halogen bond will be demonstrated in quite different fields spanning from material sciences to biomolecular recognition and drug design.
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Chemical, thermal and mechanical stabilities of metal–organic frameworks
Ashlee J. Howarth,Yangyang Liu,Peng Li,Zhanyong Li,Timothy C. Wang,Joseph T. Hupp,Omar K. Farha,Omar K. Farha +7 more
TL;DR: In this paper, the chemical, thermal and mechanical stabilities of MOFs, in particular with catalytic uses in mind, are discussed, and future directions of study for the production of highly stable MOFs are briefly discussed.
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Green and Sustainable Solvents in Chemical Processes
TL;DR: This Review considers several aspects of the most prominent sustainable organicsolvents in use today, ionic liquids, deep eutectic solvents, supercritical fluids, switchable solVents, liquid polymers, and renewable solvent, giving a more complete picture of the current status of sustainable solvent research and development.
Journal ArticleDOI
Hallmarks of mechanochemistry: From nanoparticles to technology
Peter Baláž,Marcela Achimovičová,Matej Baláž,P. Billik,P. Billik,Zara Cherkezova-Zheleva,José M. Criado,Francesco Delogu,Erika Dutková,Eric Gaffet,Francisco J. Gotor,Rakesh Kumar,Ivan Mitov,Tadej Rojac,Mamoru Senna,A. N. Streletskii,A. N. Streletskii,Krystyna Wieczorek-Ciurowa +17 more
TL;DR: The aim of this review article is to provide a comprehensive overview of advances achieved in the field of atomistic processes, phase transformations, simple and multicomponent nanosystems and peculiarities of mechanochemistry.
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Tools and techniques for solvent selection: green solvent selection guides
Fergal Byrne,Saimeng Jin,Giulia Paggiola,Tabitha H. M. Petchey,James H. Clark,Thomas J. Farmer,Andrew J. Hunt,C. Robert McElroy,James Sherwood +8 more
TL;DR: A review of general purpose solvent selection guides can be found in this paper, highlighting their similarities and differences and how they can be used to enhance the greenness of chemical processes, particularly in laboratory organic synthesis and the pharmaceutical industry.
References
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Use of a glutaric acid cocrystal to improve oral bioavailability of a low solubility API.
Daniel P. McNamara,Scott L. Childs,Jennifer Giordano,Anthony Iarriccio,James Cassidy,Manjunath S. Shet,Richard Owen Mannion,Edward Patrick O'donnell,Aeri Park +8 more
TL;DR: Use of the cocrystal increased the aqueous dissolution rate by 18 times as compared to the homomeric crystalline form of the drug and showed that it is unique regarding thermal, spectroscopic, X-ray, and dissolution properties.
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Recent Advances in Understanding the Mechanism of Cocrystal Formation via Grinding
Tomislav Friščić,William Jones +1 more
TL;DR: A brief and systematic overview of recent advances in understanding mechanochemical cocrystallization at macroscopic (bulk phase transformations) and microscopic levels (molecular recognition) is given in this article.
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Pharmaceutical Cocrystallization: Engineering a Remedy for Caffeine Hydration
TL;DR: In this paper, a systematic crystal engineering study was performed on the model pharmaceutical compound caffeine to prepare a cocrystal that, unlike caffeine, is physically stable at all relative humidities (RH).
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Recyclable Heterogeneous Palladium Catalysts in Pure Water: Sustainable Developments in Suzuki, Heck, Sonogashira and Tsuji–Trost Reactions
TL;DR: In this paper, a review summarizes the progress made essentially these last ten years on heterogeneous palladium catalysis in pure water and discusses the efficiency and reusability of the heterogeneous catalysts as well as the experimental conditions from a sustainable chemistry point of view.
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Ball milling in organic synthesis: solutions and challenges.
TL;DR: The present tutorial review will be focused on the highlights using this method of energy transfer and energy dissipation to motivate researchers to take notice of ball mills as chemical reactors, implementing this technique in everyday laboratory use and pave the ground for future activities in this interdisciplinary field of research.