Mechanochemistry: opportunities for new and cleaner synthesis
Stuart L. James,Christopher J. Adams,Carsten Bolm,Dario Braga,Paul Collier,Tomislav Friščić,Fabrizia Grepioni,Kenneth D. M. Harris,Geoff Hyett,William Jones,Anke Krebs,James Mack,Lucia Maini,A. Guy Orpen,Ivan P. Parkin,William C. Shearouse,Jonathan W. Steed,Daniel C. Waddell +17 more
TLDR
Concentrating on recent advances, this article covers industrial aspects, inorganic materials, organic synthesis, cocrystallisation, pharmaceutical aspects, metal complexes, supramolecular aspects and characterization methods.Abstract:
The aim of this critical review is to provide a broad but digestible overview of mechanochemical synthesis, i.e. reactions conducted by grinding solid reactants together with no or minimal solvent. Although mechanochemistry has historically been a sideline approach to synthesis it may soon move into the mainstream because it is increasingly apparent that it can be practical, and even advantageous, and because of the opportunities it provides for developing more sustainable methods. Concentrating on recent advances, this article covers industrial aspects, inorganic materials, organic synthesis, cocrystallisation, pharmaceutical aspects, metal complexes (including metal–organic frameworks), supramolecular aspects and characterization methods. The historical development, mechanistic aspects, limitations and opportunities are also discussed (314 references).read more
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Mg- and Mn-MOFs Boost the Antibiotic Activity of Nalidixic Acid
Vânia André,A. Silva,Auguste Fernandes,Raquel F. M. Frade,Catarina Garcia,Patrícia Rijo,Patrícia Rijo,Alexandra M. M. Antunes,João Rocha,M. Teresa Duarte +9 more
TL;DR: It is shown that a remarkable increase of the antimicrobial activity of certain antibiotics may be achieved by delivering them in the form of BioMOFs, among the first examples containing active pharmaceutical ingredients as linkers.
Journal ArticleDOI
Aging and Ball-Milling as Low-Energy and Environmentally Friendly Methods for the Synthesis of Pd(II) Photosensitizers
TL;DR: In this paper, aging and ball milling have been used to achieve reactions of triphenylphosphine (tpp) and 1,1′-bis(diphenyl-phosphino)ferrocene (dppf) with dicyclopalladated azobenzenes (DMF), which lead to four types of tetra- or pentacoordinated complexes.
Book ChapterDOI
9.11 Useful Chemical Activation Alternatives in Solvent-Free Organic Reactions
TL;DR: In this article, a review discusses recent applications of nonconventional energy sources such as mechanochemistry (ball milling), microwave, and ultrasound activation, which have been employed to promote traditional organic reactions and organocatalytic processes under solvent-free conditions.
Journal ArticleDOI
Structural elucidation of microcrystalline MOFs from powder X-ray diffraction.
TL;DR: In this paper, a short overview of crystal structure solution from powder X-ray diffraction and how this technique has been applied in the structure solution of MOFs using direct-space strategy is given.
Journal ArticleDOI
NaCl as a solid solvent to assist the mechanochemical synthesis and post-synthesis of hierarchical porous MOFs with high I2 vapour uptake
TL;DR: The use of salts as grinding media to assist the mechanosynthesis, and the following one-pot mechanochemical post-synthesis, of hierarchically porous MOFs was carried out efficiently by ball milling, and these as-obtained HKUST-1 products showed high performance in the capture of volatile iodine.
References
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Journal ArticleDOI
A profile refinement method for nuclear and magnetic structures
TL;DR: In this paper, a structure refinement method was described which does not use integrated neutron powder intensities, single or overlapping, but employs directly the profile intensities obtained from step-scanning measurements of the powder diagram.
Journal ArticleDOI
A chemically functionalizable nanoporous material (Cu3(TMA)2(H2O)3)n
TL;DR: In this paper, a highly porous metal coordination polymer [Cu3(TMA)2(H2O)3]n (where TMA is benzene-1,3,5-tricarboxylate) was formed in 80 percent yield.
Journal ArticleDOI
The Sonogashira Reaction: A Booming Methodology in Synthetic Organic Chemistry†
Rafael Chinchilla,Carmen Nájera +1 more
TL;DR: Transition-Metal-Free Reactions, Alkynylation of Heterocycles, and Synthesis of Electronic and Electrooptical Molecules: A Review.
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Journal ArticleDOI
Rietveld refinement guidelines
TL;DR: A set of general guidelines for structure refinement using the Rietveld (whole profile) method has been formulated by the International Union of Crystallography Commission on Powder Diffraction.