Mechanochemistry: opportunities for new and cleaner synthesis
Stuart L. James,Christopher J. Adams,Carsten Bolm,Dario Braga,Paul Collier,Tomislav Friščić,Fabrizia Grepioni,Kenneth D. M. Harris,Geoff Hyett,William Jones,Anke Krebs,James Mack,Lucia Maini,A. Guy Orpen,Ivan P. Parkin,William C. Shearouse,Jonathan W. Steed,Daniel C. Waddell +17 more
TLDR
Concentrating on recent advances, this article covers industrial aspects, inorganic materials, organic synthesis, cocrystallisation, pharmaceutical aspects, metal complexes, supramolecular aspects and characterization methods.Abstract:
The aim of this critical review is to provide a broad but digestible overview of mechanochemical synthesis, i.e. reactions conducted by grinding solid reactants together with no or minimal solvent. Although mechanochemistry has historically been a sideline approach to synthesis it may soon move into the mainstream because it is increasingly apparent that it can be practical, and even advantageous, and because of the opportunities it provides for developing more sustainable methods. Concentrating on recent advances, this article covers industrial aspects, inorganic materials, organic synthesis, cocrystallisation, pharmaceutical aspects, metal complexes (including metal–organic frameworks), supramolecular aspects and characterization methods. The historical development, mechanistic aspects, limitations and opportunities are also discussed (314 references).read more
Citations
More filters
Journal ArticleDOI
Mechanochemical activation of serpentine for recovering Cu (II) from wastewater.
TL;DR: In this article, a novel method for copper removal was introduced, in which serpentine, a hydrated magnesium silicate, was activated by mechanical force to raise its reactivity as high as Mg hydroxide to remove Cu (II) from wastewater.
Journal ArticleDOI
Solventless mechanosynthesis of N-protected amino esters.
TL;DR: A planetary ball mill proved to be more suitable for the synthesis of amino esters from N-protected amino acids via a one-pot activation/esterification reaction in the presence of various dialkyl dicarbonates or chloroformates.
Journal ArticleDOI
Drug Salt Formation via Mechanochemistry: The Case Study of Vincamine
Dritan Hasa,Beatrice Perissutti,Cinzia Cepek,Sunil Bhardwaj,Elvio Carlino,Mario Grassi,Sergio Invernizzi,Dario Voinovich +7 more
TL;DR: In the case of forming salts of poorly soluble drugs, the SEAMS process may be an interesting alternative to both classical synthetic routes, eliminating the need for solvent removal, and simple neat mechanochemical salification, overcoming the problem of limited process yield.
Journal ArticleDOI
Enhancing luminescence properties of lanthanide(III)/pyrimidine-4,6-dicarboxylato system by solvent-free approach
Javier Cepeda,Sonia Pérez-Yáñez,Garikoitz Beobide,Oscar Castillo,José Ángel García,Mónica Lanchas,Antonio Luque +6 more
TL;DR: Magnetic properties have been analysed for all compounds, through the variable temperature susceptibility and field dependent magnetization, and Decay lifetime measurements indicate long-lived excitation states in the compounds by achieving values in the range of millisecond for the terbium compound.
Journal ArticleDOI
Antibacterial activity of the sediment of copper removal from wastewater by using mechanically activated calcium carbonate
TL;DR: In this paper, the method of mechanically activated CaCO3 was used for copper removal from wastewater and the removal rate reached as high as 99.9% even with the Ca/Cu molar ratio of 1.0 and the residual copper concentration was less than 0.5
References
More filters
Journal ArticleDOI
A profile refinement method for nuclear and magnetic structures
TL;DR: In this paper, a structure refinement method was described which does not use integrated neutron powder intensities, single or overlapping, but employs directly the profile intensities obtained from step-scanning measurements of the powder diagram.
Journal ArticleDOI
A chemically functionalizable nanoporous material (Cu3(TMA)2(H2O)3)n
TL;DR: In this paper, a highly porous metal coordination polymer [Cu3(TMA)2(H2O)3]n (where TMA is benzene-1,3,5-tricarboxylate) was formed in 80 percent yield.
Journal ArticleDOI
The Sonogashira Reaction: A Booming Methodology in Synthetic Organic Chemistry†
Rafael Chinchilla,Carmen Nájera +1 more
TL;DR: Transition-Metal-Free Reactions, Alkynylation of Heterocycles, and Synthesis of Electronic and Electrooptical Molecules: A Review.
Journal ArticleDOI
Asymmetric enamine catalysis.
Journal ArticleDOI
Rietveld refinement guidelines
TL;DR: A set of general guidelines for structure refinement using the Rietveld (whole profile) method has been formulated by the International Union of Crystallography Commission on Powder Diffraction.