Journal ArticleDOI
Metformin induces ferroptosis by targeting miR-324-3p/GPX4 axis in breast cancer.
TLDR
In this article, the effect of metformin on breast cancer was explored and the underlying mechanism of the mechanism was clarified. But, the results showed that the effect was mediated by directly targeting glutathione peroxidase 4 (GPX4) and led to downregulation of GPX4.Abstract:
Metformin is a widely prescribed hypoglycemic drug. Many studies have shown its anti-cancer properties. In the present study, we aimed to explore the effect of metformin on breast cancer and clarify the underlying mechanism. Our results showed that metformin induced ferroptosis in MDA-MB-231 cells through upregulating miR-324-3p expression. Overexpression of miR-324-3p inhibited cancer cell viability. miR-324-3p inhibitor promoted cell viability. Further studies showed that the effect of miR-324-3p was mediated by directly targeting glutathione peroxidase 4 (GPX4). miR-324-3p bound to the 3'-UTR of GPX4 and led to the downregulation of GPX4. In vivo studies showed that metformin induced ferroptosis by upregulating miR-324-3p in the xenograft model of breast cancer in mice. Our study suggested that metformin promotes ferroptosis of breast cancer by targeting the miR-324-3p/GPX4 axis. Metformin could act as a potential anti-cancer agent through the induction of ferroptosis.read more
Citations
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System Xc −/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy
TL;DR: This review aims to present the current understanding of the mechanism of ferroptosis based on the System Xc −/GSH/GPX4 axis in the treatment of drug-resistant solid tumors.
Journal ArticleDOI
Ferroptosis in Cancer Progression: Role of Noncoding RNAs
Ying Zuo,Yinfeng Zhang,Rui Zhang,Jiaxun Tian,Xiaobing Lv,Rong Li,Shu-Ping Li,Meng-Die Cheng,Jing. Shan,Zheng Zhao,Hui Xin +10 more
TL;DR: This review systematically summarized the relationship between ferroptosis-associated ncRNAs and cancer progression and may provide new ideas for exploring novel diagnostic and therapeutic biomarkers for cancer in the future.
Journal ArticleDOI
A New Ferroptosis-Related lncRNA Signature Predicts the Prognosis of Bladder Cancer Patients
TL;DR: Zhang et al. as discussed by the authors constructed a predictive signature based on ferroptosis-related long noncoding RNAs (lncRNAs) to predict the prognosis of bladder cancer patients.
Journal ArticleDOI
New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway.
Sheng-Kai Hsu,Kai-Chun Cheng,Miracle Oluebube Mgbeahuruike,Yi-Hsiung Lin,Chang-Yi Wu,Chang-Yi Wu,Hui-Min David Wang,Chia-Hung Yen,Chien-Chih Chiu,Shwu-Jiuan Sheu +9 more
TL;DR: In this article, the anticancer effects of metformin and its potential modulation of several novel types of non-apoptotic cell death, including ferroptosis, pyroptoses, and necroptosis are discussed.
Journal ArticleDOI
Non-coding RNAs and ferroptosis: potential implications for cancer therapy
Amar Balihodžić,Felix Prinz,Michael A. Dengler,George A. Calin,Philipp J. Jost,Martin Pichler +5 more
TL;DR: In this article , a review of ncRNAs implicated in the regulation of ferroptosis in cancer and highlights their underlying molecular mechanisms in the light of potential therapeutic applications is presented.
References
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Journal ArticleDOI
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Scott J. Dixon,Kathryn M. Lemberg,Michael R. Lamprecht,Rachid Skouta,Eleina M. Zaitsev,Caroline E Gleason,Darpan N Patel,Andras J. Bauer,Alexandra M. Cantley,Wan Seok Yang,Barclay Morrison,Brent R. Stockwell,Brent R. Stockwell +12 more
TL;DR: This paper identified the small molecule ferrostatin-1 as a potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices, suggesting similarities between these two processes.
Journal ArticleDOI
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Brent R. Stockwell,José Pedro Friedmann Angeli,Hülya Bayır,Ashley I. Bush,Marcus Conrad,Scott J. Dixon,Simone Fulda,Susan Gascon,Stavroula K. Hatzios,Valerian E. Kagan,Kay Noel,Xuejun Jiang,Andreas Linkermann,Maureen E. Murphy,Michael Overholtzer,Atsushi Oyagi,Gabriela Carolina Pagnussat,Jason Park,Qitao Ran,Craig S. Rosenfeld,Konstantin Salnikow,Daolin Tang,Daolin Tang,Frank M. Torti,Suzy V. Torti,Shinya Toyokuni,K. A. Woerpel,Donna D. Zhang +27 more
TL;DR: The mechanisms underlying ferroptosis are reviewed, connections to other areas of biology and medicine are highlighted, and tools and guidelines for studying this emerging form of regulated cell death are recommended.
Journal ArticleDOI
Mechanisms of ferroptosis
TL;DR: Outstanding questions include the relationship between ferroPTosis and other forms of cell death, and whether activation or inhibition of ferroptosis can be exploited to achieve desirable therapeutic ends.
Journal ArticleDOI
Breast Cancer Subtype Approximated by Estrogen Receptor, Progesterone Receptor, and HER-2 Is Associated With Local and Distant Recurrence After Breast-Conserving Therapy
Paul L. Nguyen,Alphonse G. Taghian,Matthew S. Katz,Andrzej Niemierko,Rita Abi Raad,Whitney L. Boon,Jennifer R. Bellon,Julia S. Wong,Barbara L. Smith,Jay R. Harris +9 more
TL;DR: Overall, the 5-year local recurrence rate after BCT was low, but varied by subtype as approximated using ER, PR, and HER-2 status, which may be useful in counseling patients about their anticipated outcome after B CT.
Journal ArticleDOI
MicroRNA expression and function in cancer
TL;DR: Large high-throughput studies in patients revealed that miRNA profiling have the potential to classify tumors with high accuracy and predict outcome and the role of miRNAs in the pathogenesis of cancer is examined.
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