Multipotent cells can be generated in vitro from several adult human organs (heart, liver, and bone marrow)
Antonio Paolo Beltrami,Daniela Cesselli,Natascha Bergamin,Patrizia Marcon,Silvia Rigo,Elisa Puppato,Federica D'Aurizio,Roberto Verardo,Silvano Piazza,Angela Pignatelli,Alessandra Poz,Umberto Baccarani,Daniela Damiani,Renato Fanin,Laura Mariuzzi,Nicoletta Finato,Paola Masolini,Silvia Burelli,Ottorino Belluzzi,Claudio Schneider,Carlo Alberto Beltrami +20 more
TLDR
The findings demonstrate that an in vitro protocol to generate and expand cells from multiple organs that could be induced to acquire morphologic and functional features of mature cells even embryologically not related to the tissue of origin.About:
This article is published in Blood.The article was published on 2007-11-01 and is currently open access. It has received 359 citations till now. The article focuses on the topics: Multipotent Stem Cell & Adult stem cell.read more
Citations
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Mesenchymal Stem Cells: Revisiting History, Concepts, and Assays
TL;DR: The experimental origin of the concept of the population(s) referred to as mesenchymal stem cells and the experimental framework required to assess their stemness and function are revisited.
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Human cardiac stem cells
Claudia Bearzi,Marcello Rota,Toru Hosoda,Jochen Tillmanns,Angelo Nascimbene,Antonella De Angelis,Saori Yasuzawa-Amano,Irina Trofimova,Robert W. Siggins,Nicole LeCapitaine,Stefano Cascapera,Antonio Paolo Beltrami,David A. D'Alessandro,Elias Zias,Federico Quaini,Konrad Urbanek,Robert E. Michler,Roberto Bolli,Jan Kajstura,Annarosa Leri,Piero Anversa +20 more
TL;DR: The identification in vitro of a class of human c-kit-positive cardiac cells that possess the fundamental properties of stem cells: they are self-renewing, clonogenic, and multipotent is reported.
Journal ArticleDOI
Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow
Satoru Morikawa,Yo Mabuchi,Yoshiaki Kubota,Yasuo Nagai,Kunimichi Niibe,Emi Hiratsu,Sadafumi Suzuki,Chikako Miyauchi-Hara,Narihito Nagoshi,Takehiko Sunabori,Shigeto Shimmura,Atsushi Miyawaki,Taneaki Nakagawa,Toshio Suda,Hideyuki Okano,Yumi Matsuzaki +15 more
TL;DR: This study used phenotypic, morphological, and functional criteria to identify and prospectively isolate a subset of MSCs (PDGFRα+Sca-1+CD45−TER119−) from adult mouse bone marrow and provided the useful method needed to identify M SCs as defined in vivo entities.
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Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis
TL;DR: Takeaway is that gingiva-derived mesenchymal stem cells can function as an immunomodulatory and anti-inflammatory component of the immune system in vivo and is a promising cell source for cell-based treatment in experimental inflammatory diseases.
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Oct4 Expression Is Not Required for Mouse Somatic Stem Cell Self-Renewal
Christopher J. Lengner,Fernando D. Camargo,Konrad Hochedlinger,G. Grant Welstead,Samir Zaidi,Sumita Gokhale,Hans R. Schöler,Alexey Tomilin,Rudolf Jaenisch +8 more
TL;DR: It is concluded that Oct4 is dispensable for both self-renewal and maintenance of somatic stem cells in the adult mammal.
References
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Pluripotency of mesenchymal stem cells derived from adult marrow
Yuehua Jiang,Balkrishna N. Jahagirdar,R. Lee Reinhardt,Robert E. Schwartz,C. Dirk Keene,Xilma R. Ortiz-Gonzalez,Morayma Reyes,Todd Lenvik,Troy C. Lund,Mark Blackstad,Jingbo Du,Sara Aldrich,Aaron Lisberg,Walter C. Low,David A. Largaespada,Catherine M. Verfaillie +15 more
TL;DR: It is reported here that cells co-purifying with mesenchymal stem cells—termed here multipotent adult progenitor cells or MAPCs—differentiate, at the single cell level, not only into meschymal cells, but also cells with visceral mesoderm, neuroectoderm and endoderm characteristics in vitro.
Journal ArticleDOI
Core transcriptional regulatory circuitry in human embryonic stem cells.
Laurie A. Boyer,Tong Ihn Lee,Megan F. Cole,Sarah E. Johnstone,Stuart S. Levine,Jacob P. Zucker,Matthew G. Guenther,Roshan M. Kumar,Heather L. Murray,Richard G. Jenner,David K. Gifford,David K. Gifford,David K. Gifford,Douglas A. Melton,Douglas A. Melton,Rudolf Jaenisch,Richard A. Young,Richard A. Young +17 more
TL;DR: Insight is provided into the transcriptional regulation of stem cells and how OCT4, SOX2, and NANOG contribute to pluripotency and self-renewal and how they collaborate to form regulatory circuitry consisting of autoregulatory and feedforward loops.
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Adult Cardiac Stem Cells Are Multipotent and Support Myocardial Regeneration
Antonio Paolo Beltrami,Laura Barlucchi,Daniele Torella,Mathue Baker,Federica Limana,Stefano Chimenti,Hideko Kasahara,Marcello Rota,Ezio Musso,Konrad Urbanek,Annarosa Leri,Jan Kajstura,Bernardo Nadal-Ginard,Piero Anversa +13 more
TL;DR: The existence of Lin(-) c-kit(POS) cells with the properties of cardiac stem cells, which are self-renewing, clonogenic, and multipotent, giving rise to myocytes, smooth muscle, and endothelial cells are reported.
Journal ArticleDOI
Adult rat and human bone marrow stromal cells differentiate into neurons
TL;DR: Adult marrow stromal cells can be induced to overcome their mesenchymal commitment and may constitute an abundant and accessible cellular reservoir for the treatment of a variety of neurologic diseases.
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The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
Sheng Zhou,John D. Schuetz,Kevin D. Bunting,Anne-Marie Colapietro,Janardhan Sampath,John J. Morris,Irina Lagutina,Gerard Grosveld,Mitsujiro Osawa,Hiromitsu Nakauchi,Brian P. Sorrentino +10 more
TL;DR: Results show that expression of the Bcrp1/ABCG2 gene is an important determinant of the SP phenotype, and that it might serve as a marker for stem cells from various sources.