Journal ArticleDOI
Natural history of chronic hepatitis B: Special emphasis on disease progression and prognostic factors
TLDR
There is a growing understanding of viral, host and environmental factors influencing disease progression, which ultimately could improve the management of chronic hepatitis B.About:
This article is published in Journal of Hepatology.The article was published on 2008-02-01. It has received 1172 citations till now. The article focuses on the topics: HBeAg & Hepatitis B.read more
Citations
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Journal ArticleDOI
EASL-EORTC clinical practice guidelines : management of hepatocellular carcinoma
Peter R. Galle,Alejandro Forner,Josep M. Llovet,Vincenzo Mazzaferro,Fabio Piscaglia,Jean-Luc Raoul,Peter Schirmacher,Valérie Vilgrain +7 more
TL;DR: The following Clinical Practice Guidelines will give up-to-date advice for the clinical management of patients with hepatocellular carcinoma, as well as providing an in-depth review of all the relevant data leading to the conclusions herein.
Journal ArticleDOI
Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma
TL;DR: This review summarizes the risk factors for HCC among HBV- or HCV-infected individuals, based on findings from epidemiologic studies and meta-analyses, as well as determinants of patient outcome and the HCC disease burden, globally and in the United States.
EASL-EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma European Association for the Study of the Liver ⇑ , European Organisation for Research and Treatment of Cancer
Josep M. Llovet,Michel Ducreux,Riccardo Lencioni,Adrian M. Di Bisceglie,Jean-Francois J. DuFour,Tim F. Greten,Eric Raymond,Tania Roskams,Vincenzo Mazzaferro,Jordi Bruix,Massimo Colombo,Andrew X. Zhu +11 more
TL;DR: The purpose of this document is to assist physicians, patients, health-care providers, and health-policy makers from Europe and worldwide in the decision-making process according to evidencebased data.
Journal ArticleDOI
EASL Clinical Practice Guidelines: Management of chronic hepatitis B
C.P.G.P.P. Marcellin,G.M. Dusheiko,Fabien Zoulim,Rafael Esteban,Stephanos J. Hadziyannis,Pietro Lampertico,M.P. Manns,Daniel Shouval,Cihan Yurdaydin,R.A. Craxi,Xavier Forns,Darius Moradpour,Jean-Michel Pawlotsky,Jörg Petersen,H.W.F. Easl +14 more
TL;DR: The objective of these EASL Clinical Practice Guidelines is to update recommendations for the optimal management of chronic hepatitis B (CHB) and the CPGs do not focus on prevention and vaccination.
Journal ArticleDOI
Hepatitis B virus infection
TL;DR: Developing new therapies that can improve HBsAg clearance and virological cure is warranted because long-term antiviral treatment can reverse cirrhosis and reduce hepatocellular carcinoma.
References
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Journal ArticleDOI
Impact of the hepatitis B virus genotype and genotype mixtures on the course of liver disease in Vietnam
Nguyen Linh Toan,Le Huu Song,Peter G. Kremsner,Peter G. Kremsner,Dinh N. Duy,Vu Q. Binh,Bernd Koeberlein,Stefan Kaiser,Reinhard Kandolf,Joseph Torresi,C.-Thomas Bock +10 more
TL;DR: Differences in the replication‐phenotype of single genotypes compared to genotype‐mixtures suggest that co‐infection with different HBV‐genotypes is associated with altered pathogenesis and clinical outcome.
Journal ArticleDOI
Southern Europe as an example of interaction between various environmental factors: a systematic review of the epidemiologic evidence.
TL;DR: A systematic review of epidemiologic studies carried out on HCC aetiology in Southern Europe, an area with an intermediate–high prevalence of these agents as well as of putative risk factors, supports a role of tobacco smoking, diabetes and obesity as single agents or preferably co-factors in causing HCC.
Journal ArticleDOI
Characteristics of patients with chronic hepatitis B in France: predominant frequency of HBe antigen negative cases.
Jean-Pierre Zarski,Patrick Marcellin,Vincent Leroy,Christian Trepo,Didier Samuel,Nathalie Ganne-Carrié,Karl Barange,Valérie Canva,Michel Doffoel,Paul Calès +9 more
TL;DR: HBeAg-negative chronic hepatitis B is predominant in France and this observation is important for an optimized clinical management and future therapeutic trials in Chronic hepatitis B.
Journal ArticleDOI
Impact of non-alcoholic fatty liver disease on chronic hepatitis B.
Silvia Bondini,Jillian Kallman,Angela Wheeler,Shivaani Prakash,Terry Gramlich,Daniel M. Jondle,Zobair M. Younossi +6 more
TL;DR: The impact of superimposed non‐alcoholic fatty liver disease (NAFLD) is well established in patients with chronic hepatitis C (CH‐C), but the impact in patientsWith chronic hepatitis B ( CH‐B) is less clear.
Journal ArticleDOI
Natural course following the onset of cirrhosis in patients with chronic hepatitis B: a long-term follow-up study.
TL;DR: It is suggested that patients with older age at onset of Cirrhosis and persistent HBeAg seropositivity following the onset of cirrhosis were independent factors for the disease progression in the first 10-year after the development of cir rhosis in patients with chronic hepatitis B.