Journal ArticleDOI
Natural history of chronic hepatitis B: Special emphasis on disease progression and prognostic factors
TLDR
There is a growing understanding of viral, host and environmental factors influencing disease progression, which ultimately could improve the management of chronic hepatitis B.About:
This article is published in Journal of Hepatology.The article was published on 2008-02-01. It has received 1172 citations till now. The article focuses on the topics: HBeAg & Hepatitis B.read more
Citations
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EASL-EORTC clinical practice guidelines : management of hepatocellular carcinoma
Peter R. Galle,Alejandro Forner,Josep M. Llovet,Vincenzo Mazzaferro,Fabio Piscaglia,Jean-Luc Raoul,Peter Schirmacher,Valérie Vilgrain +7 more
TL;DR: The following Clinical Practice Guidelines will give up-to-date advice for the clinical management of patients with hepatocellular carcinoma, as well as providing an in-depth review of all the relevant data leading to the conclusions herein.
Journal ArticleDOI
Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma
TL;DR: This review summarizes the risk factors for HCC among HBV- or HCV-infected individuals, based on findings from epidemiologic studies and meta-analyses, as well as determinants of patient outcome and the HCC disease burden, globally and in the United States.
EASL-EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma European Association for the Study of the Liver ⇑ , European Organisation for Research and Treatment of Cancer
Josep M. Llovet,Michel Ducreux,Riccardo Lencioni,Adrian M. Di Bisceglie,Jean-Francois J. DuFour,Tim F. Greten,Eric Raymond,Tania Roskams,Vincenzo Mazzaferro,Jordi Bruix,Massimo Colombo,Andrew X. Zhu +11 more
TL;DR: The purpose of this document is to assist physicians, patients, health-care providers, and health-policy makers from Europe and worldwide in the decision-making process according to evidencebased data.
Journal ArticleDOI
EASL Clinical Practice Guidelines: Management of chronic hepatitis B
C.P.G.P.P. Marcellin,G.M. Dusheiko,Fabien Zoulim,Rafael Esteban,Stephanos J. Hadziyannis,Pietro Lampertico,M.P. Manns,Daniel Shouval,Cihan Yurdaydin,R.A. Craxi,Xavier Forns,Darius Moradpour,Jean-Michel Pawlotsky,Jörg Petersen,H.W.F. Easl +14 more
TL;DR: The objective of these EASL Clinical Practice Guidelines is to update recommendations for the optimal management of chronic hepatitis B (CHB) and the CPGs do not focus on prevention and vaccination.
Journal ArticleDOI
Hepatitis B virus infection
TL;DR: Developing new therapies that can improve HBsAg clearance and virological cure is warranted because long-term antiviral treatment can reverse cirrhosis and reduce hepatocellular carcinoma.
References
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Journal ArticleDOI
Relative risks of death due to liver disease among Japanese male adults having various statuses for hepatitis B s and e antigen/antibody in serum: a prospective study.
Koshi Sakuma,Nobuteru Saitoh,Misako Kasai,Hiroshi Jitsukawa,Izumi Yoshino,Momoko Yamaguchi,Kouichi Nobutomo,Makoto Yamumi,Fumio Tsuda,Tsutomu Komazawa,Tetsuo Nakamura,Yasuo Yoshida,Kunio Okuda +12 more
TL;DR: Taking advantage of the compulsory annual medical check‐up at the Central Institute of Health, Japan National Railways, hepatitis B seromarkers were tested in male employees at work and their “dead and alive” status was followed for more than 6 years for their prognostic significance.
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Regulation of Hepatitis B Virus Core Promoter by Transcription Factors HNF1 and HNF4 and the Viral X Protein
TL;DR: The results indicate that the phenotypic differences of HBV WT and double-mutant core promoters are at least partially due to the differential activities of HNF1, HNF4, and the X protein on these two promoters.
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Association of transforming growth factor-β1 gene polymorphisms with a hepatocellular carcinoma risk in patients with chronic hepatitis B virus infection
Yoon Jun Kim,Hyo Suk Lee,Jong Pil Im,Byung-Hoon Min,Hyun Dae Kim,Ji Bong Jeong,Jung Hwan Yoon,Chung Yong Kim,Myung-Soo Kim,Jun Yeon Kim,Ji Hyun Jung,Lyoung Hyo Kim,Byung Lae Park,Hyoung Doo Shin +13 more
TL;DR: The presence of the TGF-β1 -509C>T promoter or of the L10P polymorphism, and the combination of both [-509C] as a haplotype were strongly associated with a reduced risk of HCC in patients with chronic HBV infection.
Journal ArticleDOI
Survival and prognostic indicators in patients with hepatitis B virus-related cirrhosis after onset of hepatic decompensation.
Alex Yui Hui,Henry Lik-Yuen Chan,Nancy Leung,Lawrence Cheung-Tsui Hung,Francis K.L. Chan,Joseph J.Y. Sung +5 more
TL;DR: This study showed that of CHB patients who developed the first episode of hepatic decompensation, those with hepatic encephalopathy or significant hypoalbuminemia or both have worse prognoses and should be considered potential candidates for liver transplantation.
Journal ArticleDOI
Long-term outcome of chronic hepatitis B based on histological grade and stage
Byung Kyu Park,Young Nyun Park,Sang Hoon Ahn,Kwan Sik Lee,Chae Yoon Chon,Young Myoung Moon,Chanil Park,Kwang Hyub Han +7 more
TL;DR: This study evaluated the long‐term outcome and prognostic factors of chronic hepatitis B, based on histological grade and stage, and found that the former is more predictive of death than the latter.