Journal ArticleDOI
Natural history of chronic hepatitis B: Special emphasis on disease progression and prognostic factors
TLDR
There is a growing understanding of viral, host and environmental factors influencing disease progression, which ultimately could improve the management of chronic hepatitis B.About:
This article is published in Journal of Hepatology.The article was published on 2008-02-01. It has received 1172 citations till now. The article focuses on the topics: HBeAg & Hepatitis B.read more
Citations
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Journal ArticleDOI
Liver fibrosis in treatment-naïve HIV-infected and HIV/HBV co-infected patients: Zambia and Switzerland compared.
Gilles Wandeler,Lloyd Mulenga,Lloyd Mulenga,Michael J. Vinikoor,Michael J. Vinikoor,Helen Kovari,Manuel Battegay,Alexandra Calmy,Matthias Cavassini,Enos Bernasconi,Patrick Schmid,Carolyn Bolton-Moore,Carolyn Bolton-Moore,Edford Sinkala,Benjamin H. Chi,Matthias Egger,Matthias Egger,Andri Rauch +17 more
TL;DR: Despite the differences in HBV natural history between Sub-Saharan Africa and Europe, the degree of liver fibrosis and the association with important risk factors were similar and male sex was a strong risk factor for significant Liver fibrosis.
Journal ArticleDOI
Pediatric hepatitis B treatment
TL;DR: There is no clear evidence that the induction of HBeAg seroconversion by antiviral treatment prevents the progression of liver disease to cirrhosis and hepatocellular carcinoma in children with chronic HBV infection, so it is imperative to clarify the clinical impact of antiviral treated in children.
Journal ArticleDOI
Association of human leukocyte antigen DQB1 and DRB1 alleles with chronic hepatitis B.
Levent Doganay,Arta Fejzullahu,Seyma Katrinli,Feruze Yilmaz Enc,Oguzhan Ozturk,Yasar Colak,Celal Ulasoglu,Ilyas Tuncer,Gizem Dinler Doganay +8 more
TL;DR: It is demonstrated that HLA alleles may influence cirrhosis development and disease activity in Turkish chronic hepatitis B patients and that a polymorphic amino acid sequence in DRB1*07 may alter interaction with the T-cell recognition site.
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Diagnostic value of FIB-4 for liver fibrosis in patients with hepatitis B: a meta-analysis of diagnostic test.
TL;DR: FIB-4 has relatively high diagnostic value for detecting liver fibrosis in patients with hepatitis B when the diagnostic threshold value is more than 2.0 and cut-off was the source of heterogeneity in the present study.
Journal ArticleDOI
Reduced hepatic steatosis is associated with higher risk of hepatocellular carcinoma in chronic hepatitis B infection
Lung-Yi Mak,Rex Wan-Hin Hui,James Fung,Fen Liu,Danny Ka-Ho Wong,Bofei Li,Ka Shing Cheung,Man-Fung Yuen,Wai-Kay Seto +8 more
TL;DR: Reduced hepatic steatosis was significantly associated with a higher risk of incident HCC in CHB infection and routine CAP and LS measurements are important for risk stratification.
References
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Measuring inconsistency in meta-analyses
TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
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Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level.
Chien-Jen Chen,Hwai I. Yang,Jun Su,C.-L. Jen,San Lin You,Sheng-Nan Lu,Guan-Tarn Huang,Uchenna H. Iloeje +7 more
TL;DR: Elevated serum HBV DNA level (> or =10,000 copies/mL) is a strong risk predictor of hepatocellular carcinoma independent of HBeAg, serum alanine aminotransferase level, and liver cirrhosis.
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Chronic hepatitis B
Anna S. Lok,Brian J. McMahon +1 more
TL;DR: These guidelines have been written to assist physicians and other health care providers in the recognition, diagnosis, and management of patients chronically infected with the hepatitis B virus (HBV).
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The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide
TL;DR: HBV and HCV infections account for the majority of cirrhosis and primary liver cancer throughout most of the world, highlighting the need for programs to prevent new infections and provide medical management and treatment for those already infected.
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Hepatocellular carcinoma in cirrhosis: incidence and risk factors.
TL;DR: Further studies are needed to investigate other viral factors (eg, HBV genotype/mutant, occult HBV, HIV coinfection) and preventable or treatable comorbidities ( eg, obesity, diabetes) in the HCC risk in cirrhosis.