Journal ArticleDOI
Natural history of chronic hepatitis B: Special emphasis on disease progression and prognostic factors
TLDR
There is a growing understanding of viral, host and environmental factors influencing disease progression, which ultimately could improve the management of chronic hepatitis B.About:
This article is published in Journal of Hepatology.The article was published on 2008-02-01. It has received 1172 citations till now. The article focuses on the topics: HBeAg & Hepatitis B.read more
Citations
More filters
Journal ArticleDOI
Plasma diamine oxidase level predicts 6-month readmission for patients with hepatitis B virus-related decompensated cirrhosis
TL;DR: Plasma DAO level predicts high rate of 6-month readmission in patients with HBV-related decompensated cirrhosis, and has the higher AUROC than CPT score for the onset of recurrent HE.
Dissertation
Characterization of Hepatitis B Viral Drug Resistance inIndian Subcontinent Patients with Chronic Liver Disease.
TL;DR: It is hypothesized that high viral genetic diversity, elevated baseline serum aminotransferases and spontaneous anti-HBe seroconversion coupled with antiviral action play an effective role in clearing the viral infection.
Posted ContentDOI
Association analysis of KIR/HLA genotype with liver cirrhosis, hepatocellular carcinoma, and NUC freedom in chronic hepatitis B patients
Satoru Joshita,Masao Ota,Hiroyuki Kobayashi,Shun-Ichi Wakabayashi,Yuki Yamashita,Ayumi Sugiura,Tomoo Yamazaki,Eiji Tanaka,Takeji Umemura +8 more
TL;DR: In this article, the association of KIR/HLA pairs with progression to liver cirrhosis, hepatocellular carcinoma (HCC) development, and nucleot(s)ide (NUC) treatment freedom in hepatitis B virus (HBV) infection was investigated.
Journal ArticleDOI
Évaluation du rôle de l’aflatoxine B1 dans l’apparition du carcinome hépatocellulaire en Côte d’Ivoire : étude préliminaire
Pierre Manda,Aholia Jean Baptiste Adepo,Alphonsine Kouassi Mbengue,Michel Konan,Jean Verdier N’gbe,Moussa Doumbia,Toussaint Toutou,Sébastien Djédjé Dano +7 more
TL;DR: L’effet synergique entre les aflatoxines et les hepatites virales B pourrait constituer un facteur de risque important dans l’apparition du CHC en Cote d’Ivoire.
Journal ArticleDOI
A336C/A336T/T337C variations in HBV core gene and spontaneous hepatitis B e antigen loss in chronic hepatitis B patients.
TL;DR: A336C/A336T/T337C were naturally occurring polymorphisms in HBV core gene, and moreover, the presence of C336/T336/C337 variants was first demonstrated to be an independent factor associating with spontaneous HBeAg loss in chronic hepatitis B patients.
References
More filters
Journal ArticleDOI
Measuring inconsistency in meta-analyses
TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
Journal ArticleDOI
Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level.
Chien-Jen Chen,Hwai I. Yang,Jun Su,C.-L. Jen,San Lin You,Sheng-Nan Lu,Guan-Tarn Huang,Uchenna H. Iloeje +7 more
TL;DR: Elevated serum HBV DNA level (> or =10,000 copies/mL) is a strong risk predictor of hepatocellular carcinoma independent of HBeAg, serum alanine aminotransferase level, and liver cirrhosis.
Journal ArticleDOI
Chronic hepatitis B
Anna S. Lok,Brian J. McMahon +1 more
TL;DR: These guidelines have been written to assist physicians and other health care providers in the recognition, diagnosis, and management of patients chronically infected with the hepatitis B virus (HBV).
Journal ArticleDOI
The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide
TL;DR: HBV and HCV infections account for the majority of cirrhosis and primary liver cancer throughout most of the world, highlighting the need for programs to prevent new infections and provide medical management and treatment for those already infected.
Journal ArticleDOI
Hepatocellular carcinoma in cirrhosis: incidence and risk factors.
TL;DR: Further studies are needed to investigate other viral factors (eg, HBV genotype/mutant, occult HBV, HIV coinfection) and preventable or treatable comorbidities ( eg, obesity, diabetes) in the HCC risk in cirrhosis.